GPRC5B - G protein-coupled receptor class C group 5 member B Gene

Homo sapiens

Also known as RAIG2; RAIG-2

Gene ID: 51704 | Gene type: protein coding

About GPRC5B

Cytogenetic location: 16p12.3 Genomic coordinates (GRCh38): 16:19,856,691-19,886,145 (from NCBI)

This gene has 11 transcripts (splice variants), 277 orthologues and 3 paralogues. Biased expression in brain (RPKM 139.6), testis (RPKM 34.2) and 11 other tissues.

Summary

This gene encodes a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The encoded protein may modulate Insulin secretion and increased protein expression is associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GPRC5B Products(2)

mRNA	Protein	Name
NM_001304771.1	NP_001291700.1	G-protein coupled receptor family C group 5 member B isoform 2
NM_016235.3	NP_057319.1	G-protein coupled receptor family C group 5 member B isoform 1 precursor

GPRC5B Protein Structure

7tm_3

0
100
200
300
403 a.a.

Protein Preferred Names

Protein Names

G-protein coupled receptor family C group 5 member B

G protein-coupled receptor, family C, group 1, member B

Related Diseases

Diseases

Alias

Megalencephalic Leukoencephalopathy With Subcortical Cysts

Vacuolating Megalencephalic Leukoencephalopathy With Subcortical Cysts	Mlc
Van Der Knaap Disease	Lvm
Leukoencephalopathy With Swelling And Cysts	Megalencephaly-Cystic Leukodystrophy
Megalencephalic Leukodystrophy Megalencephaly-Cystic Leukodystorphy Syndrome	Infantile Leukoencephalopathy And Megalencephaly
Leukoencephalopathy With Swelling And A Discrepantly Mild Course	Vacuolating Leukoencephalopathy
Megalencephalic Leukodystrophy	Megalencephaly-Cystic Leukodystrophy Syndrome
Van Der Knaap Syndrome	Leukoencephalopathy, Megalencephalic, With Subcortical Cysts

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05750	GPRC5B Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GPRC5B	VGNC	VGNC:54030
Macaca mulatta	GPRC5B	VGNC	VGNC:72934
Felis catus	GPRC5B	VGNC	VGNC:62694
Mus musculus	GPRC5B	MGD	MGI:1927596
Rattus norvegicus	GPRC5B	RGD	RGD:1309510
Bos taurus	GPRC5B	VGNC	VGNC:29607

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