GPRC5B - G protein-coupled receptor class C group 5 member B Gene

Also Known as RAIG2; RAIG-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51704

About GPRC5B

Cytogenetic location: 16p12.3 Genomic coordinates (GRCh38): 16:19,856,691-19,886,145 (from NCBI)

This gene has 11 transcripts (splice variants), 277 orthologues and 3 paralogues. Biased expression in brain (RPKM 139.6), testis (RPKM 34.2) and 11 other tissues.

Summary

This gene encodes a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The encoded protein may modulate Insulin secretion and increased protein expression is associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GPRC5B Products (2)

mRNA	Protein	Name
NM_001304771.1	NP_001291700.1	G-protein coupled receptor family C group 5 member B isoform 2
NM_016235.3	NP_057319.1	G-protein coupled receptor family C group 5 member B isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein kinase activator activity	IDA IDA: Inferred from direct assay	23169819	GOA
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	23169819	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell volume homeostasis	IMP IMP: Inferred from mutant phenotype	37143309	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular exosome	IDA IDA: Inferred from direct assay	21557262	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	23169819	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPRC5B Protein Structure

7tm_3

0
100
200
300
403 a.a.

Protein Preferred Names	Protein Names
G-protein coupled receptor family C group 5 member B	G protein-coupled receptor, family C, group 1, member B

GPRC5B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83219	GPRC5B Antibody (YA2964)	WB, IP	Human, Mouse, Rat
HY-P83219A	GPRC5B Antibody (YA2964)(PBS only)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Megalencephalic Leukoencephalopathy With Subcortical Cysts	Vacuolating Megalencephalic Leukoencephalopathy With Subcortical Cysts Mlc Van Der Knaap Disease Lvm Leukoencephalopathy With Swelling And Cysts Megalencephaly-Cystic Leukodystrophy Megalencephalic Leukodystrophy Megalencephaly-Cystic Leukodystorphy Syndrome Infantile Leukoencephalopathy And Megalencephaly Leukoencephalopathy With Swelling And A Discrepantly Mild Course Vacuolating Leukoencephalopathy Megalencephalic Leukodystrophy Megalencephaly-Cystic Leukodystrophy Syndrome Van Der Knaap Syndrome Leukoencephalopathy, Megalencephalic, With Subcortical Cysts

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05750	GPRC5B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19258	Gprc5b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25747	Gprc5b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GPRC5B	VGNC	VGNC:54030
Macaca mulatta	GPRC5B	VGNC	VGNC:72934
Felis catus	GPRC5B	VGNC	VGNC:62694
Mus musculus	GPRC5B	MGD	MGI:1927596
Rattus norvegicus	GPRC5B	RGD	RGD:1309510
Bos taurus	GPRC5B	VGNC	VGNC:29607
Others	GPRC5B	NCBI