PLEK - pleckstrin Gene

Also Known as P47; PLEK1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5341

About PLEK

Cytogenetic location: 2p14 Genomic coordinates (GRCh38): 2:68,365,282-68,397,453 (from NCBI)

This gene has 2 transcripts (splice variants), 205 orthologues and 1 paralogue. Biased expression in bone marrow (RPKM 230.3), lymph node (RPKM 68.5) and 6 other tissues.

Summary

Enables phosphatidylinositol-3,4-bisphosphate binding activity; protein homodimerization activity; and protein kinase C binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; actin Cytoskeleton organization; and positive regulation of supramolecular fiber organization. Located in cytoplasm and ruffle membrane. [provided by Alliance of Genome Resources, Apr 2022]

PLEK Products (1)

mRNA	Protein	Name
NM_002664.3	NP_002655.2	pleckstrin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phosphatidylinositol-3,4-bisphosphate binding	IDA IDA: Inferred from direct assay	15698571	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8999861	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	8694752	GOA
enables protein kinase C binding	IDA IDA: Inferred from direct assay	8615792	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	10497244	GOA
involved in cell projection organization	IDA IDA: Inferred from direct assay	9060471	GOA
involved in cortical actin cytoskeleton organization	IDA IDA: Inferred from direct assay	10497244	GOA
involved in hematopoietic progenitor cell differentiation	IEP IEP: Inferred from expression pattern	2768345	GOA
involved in integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	10995449	GOA
involved in negative regulation of G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	7782310	GOA
involved in negative regulation of inositol phosphate biosynthetic process	IDA IDA: Inferred from direct assay	7559487	GOA
involved in phosphatidylinositol metabolic process	IDA IDA: Inferred from direct assay	7559487	GOA
involved in phospholipase C-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	7782310	GOA
involved in platelet degranulation	IEP IEP: Inferred from expression pattern	7559487	GOA
involved in positive regulation of actin filament bundle assembly	IDA IDA: Inferred from direct assay	10497244	GOA
involved in positive regulation of actin filament depolymerization	IDA IDA: Inferred from direct assay	10497244	GOA
involved in positive regulation of inositol-polyphosphate 5-phosphatase activity	IDA IDA: Inferred from direct assay	8999861	GOA
involved in regulation of cell diameter	IDA IDA: Inferred from direct assay	10995449	GOA
involved in ruffle organization	IDA IDA: Inferred from direct assay	10497244	GOA
involved in thrombin-activated receptor signaling pathway	IDA IDA: Inferred from direct assay	7782310	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8694752	GOA
located in ruffle membrane	IDA IDA: Inferred from direct assay	9060471	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
pleckstrin	platelet 47 kDa protein

PLEK Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PLEK	P08567	WDR75	Homo sapiens	Q8IWA0	Anti Tag CoIP	33961781
Intra	PLEK	P08567	WDR75	Homo sapiens	Q8IWA0	Anti Tag CoIP	28514442
Intra	PLEK	P08567	CAVIN2	Homo sapiens	O95810	Pull Down	19722192
Intra	PLEK	P08567	CAVIN2	Homo sapiens	O95810	Anti Bait CoIP	19722192
Intra	PLEK	P08567	INPP5A	Homo sapiens	Q14642	Affinity Chrom	8999861
Intra	PLEK	P08567	INPP5A	Homo sapiens	Q14642	Anti Bait CoIP	8999861
Intra	PLEK	P08567	INPP5A	Homo sapiens	Q14642	Anti Tag CoIP	8999861

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PLEK Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73707	Pleckstrin Protein, Human (His)	P08567 (M1-K350)	≥ 95%, as determined by reducing SDS-PAGE.

PLEK Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83418	Pleckstrin Antibody (YA3163)	WB	Human
HY-P83418A	Pleckstrin Antibody (YA3163)(PBS only)	WB	Human

Related Diseases

Diseases	Alias
Aarskog-Scott Syndrome	Aarskog Syndrome Faciogenital Dysplasia Faciodigitogenital Syndrome AAS Fgdy X-Linked Aarskog Syndrome Intellectual Developmental Disorder, X-Linked, Syndromic 16 Aarskog Syndrome, X-Linked Intellectual Developmental Disorder, X-Linked Syndromic 16 Greig'S Syndrome Aarskog Scott Syndrome Aarskog Disease Scott Aarskog Syndrome Facio-Digito-Genital Dysplasia Faciogenital Dysplasia With Attention Deficit-Hyperactivity Disorder Aarskog-Scott Syndrome ) Syndrome
Agammaglobulinemia, X-Linked	X-Linked Agammaglobulinemia XLA Bruton Type Agammaglobulinemia Bruton'S Agammaglobulinemia Bruton-Type Agammaglobulinemia Agmx1 Imd1 Agammaglobulinemia, X-Linked 1 Btk-Deficiency Agammaglobulinemia Hypogammaglobulinemia Agammaglobulinemia, X-Linked, Type 1 Immunodeficiency 1 Bruton Agammaglobulinemia Tyrosine Kinase Deficiency Bruton Disease Bruton'S Agammaglobulinaemia Bruton'S Sex-Linked Agammaglobulinemia Bruton'S Type Agammaglobulinemia Btk Deficiency Agammaglobulinemia, Btk Agammaglobulinemia, Bruton Tyrosine Kinase Congenital Agammaglobulinemia Immunodeficiency Type 1 X-Linked Agammaglobulinemia Type 1
Centronuclear Myopathy	Myopathy, Centronuclear Myotubular Myopathy Cnm Myopathy, Myotubular Congenital Structural Myopathy
Agammaglobulinemia	Hypogammaglobulinemia Ighm Mu Heavy Chain Deficiency Mu-Heavy Chain Disease Mu-Hcd Mu-Chain Disease
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Charcot-Marie-Tooth Disease, Dominant Intermediate B	CMTDIB Charcot-Marie-Tooth Disease Dominant Intermediate B Di-Cmtb Cmtdi1 Autosomal Dominant Charcot-Marie-Tooth Disease Type 2m Charcot-Marie-Tooth Neuropathy Dominant Intermediate B CMT2M Charcot-Marie-Tooth Neuropathy, Dominant Intermediate B Charcot-Marie-Tooth Disease, Axonal Type 2m Autosomal Dominant Intermediate Charcot-Marie-Tooth Disease Type B Charcot-Marie-Tooth Disease 2m Charcot-Marie-Tooth Disease Axonal Autosomal Dominant Type 2m Charcot-Marie-Tooth Disease Axonal Type 2m Charcot-Marie-Tooth Neuropathy Axonal Type 2m Charcot-Marie-Tooth Disease, Dominant, Intermediate Type, B Charcot-Marie-Tooth Disease, Axonal, Type 2m Charcot-Marie-Tooth Disease, Dominant Intermediate, Type B
Osteopetrosis	Marble Bone Disease Albers-Schonberg Disease Osteopetroses Marble Bones Osteopetrosis And Related Disorders Congenital Osteopetrosis Marble Bone Albers-Schoenberg Disease Albers-Schonberg Osteopetrosis Osteosclerosis Fragilis Ivory Bones
Cowden Syndrome 1	Bannayan-Riley-Ruvalcaba Syndrome Pten Hamartoma Tumor Syndrome Lhermitte-Duclos Disease Bannayan-Zonana Syndrome Phts Riley-Smith Syndrome Bzs Ruvalcaba-Myhre-Smith Syndrome Multiple Hamartoma Syndrome Rmss Brrs Dysplastic Gangliocytoma Of The Cerebellum CWS1 Cs Cd Mham Pten Hamartoma Tumor Syndrome With Granular Cell Tumor Macrocephaly Multiple Lipomas And Hemangiomata Bannayan-Ruvalcaba-Riley Syndrome Myhre-Riley-Smith Syndrome LDD Cerebelloparenchymal Disorder Vi Hamartoma Syndrome, Multiple Bbrs Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata Macrocephaly, Multiple Lipomas, And Hemangiomata Macrocephaly Pseudopapilledema And Multiple Hemangiomas Ruvalcaba -Myhre-Smith Syndrome Ruvalcaba-Myhre Syndrome Cowden Disease Macrocephaly Pseudopapilledema And Multiple Hemangiomata Cerebellar Granule Cell Hypertrophy And Megalencephaly Cpd6 Pten Hamartoma Tumor Syndromes Cowden Syndrome, Type 1
Nystagmus 3, Congenital, Autosomal Dominant	NYS3 Congenital Nystagmus 3 Autosomal Dominant Congenital Nystagmus 3
Spinocerebellar Ataxia 5	Spinocerebellar Ataxia Type 5 SCA5 Spinocerebellar Ataxia-5 Ataxia, Spinocerebellar, Type 5
Skin Granular Cell Tumor	Granular Cell Neoplasm Of The Skin Granular Cell Tumor Of Skin Granular Cell Tumour Of Skin Skin Granular Cell Tumour
Proteus Syndrome	Proteus Syndrome, Somatic Partial Gigantism-Nevi-Hemihypertrophy-Macrocephaly Syndrome Gigantism, Partial, Of Hands And Feet, Nevi, Hemihypertrophy, And Macrocephaly Wiedemann'S Syndrome Hemihypertrophy And Macrocephaly Partial Gigantism Of Hands And Feet, Nevi, Hemihypertrophy, Macrocephaly Ps PROTEUSS Partial Gigantism Of Hands And Feet Nevi Hemihypertrophy And Macrocephaly
Leukocyte Adhesion Deficiency, Type Iii	Leukocyte Adhesion Deficiency 3 LAD3 Leukocyte Adhesion Deficiency 1 Variant Lad1v Integrin Activation Deficiency Disease Iadd Leukocyte Adhesion Deficiency Type Iii Lad1 Variant Lad-1 Variant Lad-Iii Leukocyte Adhesion Deficiency-1 Variant Leukocyte Adhesion Deficiency Type 1
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Neuropathy, Hereditary Sensory, Type Id	HSN1D Hereditary Sensory Neuropathy Type 1d Neuropathy, Hereditary Sensory, Type 1d Neuropathy, Hereditary Sensory, 1d Hereditary Sensory Neuropathy Type Id Neuropathy, Sensory, Hereditary, Type Id
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Unilateral Focal Polymicrogyria
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10677	PLEK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10678	PLEK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19367	Plek Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22732	Plek2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25859	Plek Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29246	Plek2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PLEK	VGNC	VGNC:33001
Canis familiaris	PLEK	VGNC	VGNC:44666
Macaca mulatta	PLEK	VGNC	VGNC:76174
Rattus norvegicus	PLEK	RGD	RGD:1308269
Felis catus	PLEK	VGNC	VGNC:68903
Mus musculus	PLEK	MGD	MGI:1860485
Others	PLEK	NCBI