CTSA - cathepsin A Gene

Homo sapiens

Also known as GSL; GLB2; NGBE; PPCA; PPGB

Gene ID: 5476 | Gene type: protein coding

About CTSA

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,891,335-45,898,820 (from NCBI)

This gene has 40 transcripts (splice variants), 204 orthologues, 2 paralogues and is associated with 4 phenotypes. Ubiquitous expression in adrenal (RPKM 65.7), kidney (RPKM 65.3) and 25 other tissues.

Summary

This gene encodes a member of the peptidase S10 family of serine carboxypeptidases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate two chains that comprise the heterodimeric active Enzyme. This Enzyme possesses deamidase, esterase and Carboxypeptidase activities and acts as a scaffold in the lysosomal multienzyme complex. Mutations in this gene are associated with galactosialidosis. [provided by RefSeq, Nov 2015]

CTSA Products(3)

mRNA	Protein	Name
NM_000308.4	NP_000299.3	lysosomal protective protein isoform b preproprotein
NM_001127695.3	NP_001121167.1	lysosomal protective protein isoform b preproprotein
NM_001167594.3	NP_001161066.2	lysosomal protective protein isoform c precursor

CTSA Protein Structure

Peptidase_S10

0
100
200
300
400
480 a.a.

Protein Preferred Names

Protein Names

lysosomal protective protein

beta-galactosidase 2

Recombinant CTSA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7745	Cathepsin A Protein, Human (HEK293, His, solution)	P10619 (A29-Y480)	≥95%
HY-P7745A	Cathepsin A Protein, Human (HEK293, His)	P10619 (S69-Y480)	≥95%

Related Diseases

Diseases

Alias

Galactosialidosis

Goldberg Syndrome	Neuraminidase Deficiency With Beta-Galactosidase Deficiency
Ppca Deficiency	GSL
Lysosomal Protective Protein Deficiency	Cathepsin A Deficiency
Neuraminidase/Beta-Galactosidase Expression	Protective Protein/Cathepsin A Deficiency
Ngbe	Cathepsin A Deficiency Of
Lysosomal Protective Protein Deficiency Of	Deficiency Of Cathepsin A
Neuraminidase Beta-Galactosidase Deficiency	Protective Protein Cathepsin A Deficiency

Cathepsin A-Related Arteriopathy-Strokes-Leukoencephalopathy

Carasal

Absolute Glaucoma

Blind Hypertensive Eye

Glaucoma Absolute

Glycoproteinosis

Sialidosis	Mucolipidosis Type I
Mucolipidoses	Cherry Red Spot Myoclonus Syndrome
Mucolipidosis I	Myoclonus Cherry Red Spot Syndrome
Type I Mucolipidosis	Lipomucopolysaccharidosis
Disorders Of Glycoprotein Metabolism	Glycoprotein Storage Disorder

Mucopolysaccharidosis Iv

Morquio Syndrome	Mucopolysaccharidosis Type 4
Mucopolysaccharidosis Type Iv	Morquio Disease
Galactosamine-6-Sulfatase Deficiency	Mps4
Mpsiv	Morquio-Brailsford Disease
Chondroosteodystrophy	Deficiency Of Chondroitinsulphatase
Deficiency Of N-Acetylgalactosamine-6-Sulphatase	Mucopolysaccharidosis, Mps-Iv
Osteochondrodystrophy	Morquio'S Disease
Morquio'S Syndrome	Mps Iv
Mucopolysaccharidosis Iv	Morquios Syndrome
Mucopolysaccharidosis, Mps-Iv-A	Mucopolysaccharidosis Type Ivb
Galns Deficiency

Gm1 Gangliosidosis

Beta-Galactosidase Deficiency	Gangliosidosis Gm1
Deficiency Of Beta-Galactosidase	Beta Galactosidase 1 Deficiency
Beta-Galactosidosis	Glb 1 Deficiency
Beta-Galactosidase-1 Deficiency	Beta-Galactosidase-1 Deficiency
Glb1 Deficiency	Landing Disease
Gangliosidosis, Gm1

Gangliosidosis

Gangliosidoses

Lysosomal Storage Disease

Lysosomal Storage Diseases	Disorder Of Lysosomal Enzyme
Inborn Lysosomal Enzyme Disorder	Lysosomal Storage Metabolism Disorder
Lysosomal Storage Disorder

Acute Gonococcal Salpingitis

Gonococcal Salpingitis, Specified As Acute

Angiokeratoma

Angiokeratoma Of Skin	Cutaneous Angiokeratoma
Skin Angiokeratoma

Hydrops Fetalis, Nonimmune

Hydrops Fetalis	Non-Immune Hydrops Fetalis
NIHF	Familial Non-Immune Hydrops Fetalis
Hydrops Fetalis Nonimmune	Idiopathic Hydrops Fetalis
Hb Bart'S Hydrops Fetalis	Alpha-Thalassemia Hydrops Fetalis
Alpha-Thalassemia Major	Hemoglobin Bart'S Hydrops Fetalis
Homozygous Alpha0-Thalassemia	Fetal Anasarca
Fetal Hydrops	Generalized Fetal Edema
Hf	Non-Immune Hf
Non-Immune Fetal Edema	Non-Immune Fetal Hydrops
Hydrops Fetalis, Non-Immune	Hemoglobin Bart'S Hydrops Syndrome

Atrophic Rhinitis

Rhinitis, Atrophic	Ozena
Rhinitis Sicca	Dry Rhinitis
Ozaena

Mucolipidosis

Chronic Gonococcal Salpingitis

Gonococcal Salpingitis

Scheie Syndrome

Mucopolysaccharidosis Type Is	Alpha-L-Iduronidase Deficiency
Mucopolysaccharidosis Type I	Mucopolysaccharidosis I
Hurler-Scheie Syndrome	Mucopolysaccharidosis Type 1
Mucopolysaccharidosis Is	Mucopolysaccharidosis Type 1s
Mucopolysaccharidosis Type V	Hurler Syndrome
Idua Deficiency	Mps I
MPS1S	Mps1-S
Mucopolysaccharidosis Type V, Formerly	Mps V, Formerly
Mps5, Formerly	Lipochondrodystrophy
Mpsis	Mucopolysaccharidosis, Type I
Iduronidase Deficiency Disease	Mps I - Hurler Syndrome
Mucopolysaccharidosis, Mps-I	Mucopolysaccharidosis, Type 1
Attenuated Mps I	Mps 1
Scheie Syndrome Formerly Known As Mucopolysaccharidosis Type V)	Severe Mps I
Mps I H	Mps I H-S
Mps I S	Mps1
Mpsi	Mucopolysaccharidosis 1s
Mps Is	Mps-Is
Mps V	Mucopolysaccharidosis V
Pfaundler-Hurler Syndrome	L-Iduronidase Deficiency
Dysostosis Multiplex	Dysostosis Multiplex Syndrome
Gargoylism	Mps1 - [Mucopolysaccharidosis Type 1]

Gm1-Gangliosidosis, Type Ii

Gm1 Gangliosidosis Type 2	GM1G2
Gangliosidosis, Generalized Gm1, Type 2	Juvenile Gm1 Gangliosidosis
Gangliosidosis Generalized Gm1 Type 2	Gangliosidosis, Generalized Gm1, Juvenile Type
Gangliosidosis, Generalized Gm1, Type Ii	Gangliosidosis Generalized Gm1 Juvenile Type
Late-Infantile Gm1 Gangliosidosis	Gm1-Gangliosidosis 2
Gangliosidosis Generalized Gm1 Late Infantile Type	Gm1-Gangliosidosis Generalized Juvenile Type
Gangliosidosis, Gm1, Type Ii

Cataract 48

CTRCT48

Hurler Syndrome

Mucopolysaccharidosis Ih	Mucopolysaccharidosis Type Ih
Mps1-H	MPS1H
Hurler Disease	Mpsih
Mucopolysaccharidosis Type 1h	Alpha-L-Iduronidase Deficiency
Dysostosis Multiplex	Dysostosis Multiplex Syndrome
Gargoylism	Hurler Disease Mps Type 1h
Hurler-Pfaundler Syndrome	L-Iduronidase Deficiency, Hurler Type
Mucopolysaccharidosis Type I Severe Form	Mucopolysaccharidosis 1h
Hurler'S Syndrome	Mps Ih
Mps-Ih	Pfaundler-Hurler Syndrome
Mucopolysaccharidosis I

Mucopolysaccharidosis, Type Ivb

Mucopolysaccharidosis Type Ivb	Mps Ivb
MPS4B	Morquio Syndrome B
Beta-D-Galactosidase Deficiency	Morquio Disease Type B
Mps 4b	Mucopolysaccharidosis Type 4b
Mpsivb	Morquio Disease, Type B
Mucopolysaccharidosis Type Iv-B	Mucopolysaccharidosis 4b
Morquio'S Syndrome B	Mps-Ivb

Skin Hemangioma

Angioma Of The Skin	Angiomatous Naevus Of Skin
Hemangioma Of Skin

Chronic Salpingitis

Aspartylglucosaminuria

Aspartylglycosaminuria	Glycosylasparaginase Deficiency
Aspartylglucosaminidase Deficiency	Aga Deficiency
AGU	Aspartylglucosamidase Deficiency
Glycoasparaginase	Aspartylglucosamidase Deficiency
Hyperammonemia, Type Iii

Pelvic Inflammatory Disease

Pid

Leukoencephalopathy, Hereditary Diffuse, With Spheroids 1

Hereditary Diffuse Leukoencephalopathy With Spheroids	Adult-Onset Leukoencephalopathy With Axonal Spheroids And Pigmented Glia
Alsp	Gpsc
Subcortical Gliosis Of Neumann	Leukoencephalopathy, Diffuse Hereditary, With Spheroids 1
Autosomal Dominant Leukoencephalopathy With Neuroaxonal Spheroids	Hdls
HDLS1	Leukoencephalopathy, Adult-Onset, With Axonal Spheroids And Pigmented Glia
Gliosis, Familial Progressive Subcortical	Leukoencephalopathy, Diffuse Hereditary, With Spheroids
Pold	Pigmentary Orthochromatic Leukodystrophy
Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids And Pigmented Glia	Familial Progressive Subcortical Gliosis
Leukoencephalopathy With Neuroaxonal Spheroids, Autosomal Dominant	Dementia, Familial, Neumann Type
Adult-Onset Leukodystrophy With Neuroaxonal Spheroids	Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids
Neuroaxonal Leukodystrophy	Fpsg
Familial Dementia, Neumann Type	Familial Dementia Neumann Type
Leukoencephalopathy, Diffuse Hereditary, With Spheroid

Acute Salpingitis

Mucopolysaccharidosis-Plus Syndrome

Mucopolysaccharidosis	Mucopolysaccharidosis-Like Syndrome With Congenital Heart Defects And Hematopoietic Disorders
MPSPS	Mucopolysaccharidoses
Mps	Mucopolysaccharidosis-Like Plus Disease
Disorders Of Glycosaminoglycan Metabolism

Mucopolysaccharidosis, Type Iva

Mps Iva	Galns Deficiency
MPS4A	Morquio A Disease
Galactosamine-6-Sulfatase Deficiency	Morquio Syndrome A
Mucopolysaccharidosis Iva	Mucopolysaccharidosis Type Iva
Mpsiva	Morquio Disease Type A
Mucopolysaccharidosis Type 4a	N-Acetylgalactosamine-6-Sulfate Sulfatase Deficiency
Morquio Syndrome Type A	Mps 4a
Morquio Disease, Type A	Mucopolysaccharidosis 4a
Morquio'S Syndrome A	Mps Iv A
Mucopolysaccharidosis Iv	Mucopolysaccharidosis, Mps-Iv-A

Sphingolipidosis

Sphingolipidoses

Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations

Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations	Crv
Rvcl	Rvcl-S
Vasculopathy, Retinal, With Cerebral Leukodystrophy	Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Retinal Vasculopathy With Cerebral Leukodystrophy	Retinal Vasculopathy And Cerebral Leukoencephalopathy
Hereditary Vascular Retinopathy	Hvr
RVCLS	Cerebroretinal Vasculopathy, Hereditary
Cerebroretinal Vasculopathy	Herns
Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly	Hereditary Cerebroretinal Vasculopathy
Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke	Hereditary Systemic Angiopathy
Hsa	Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations
Adrvcl	Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy
Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke	Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Atrial Septal Defect 1

ASD1	Atrial Heart Septal Defect 1
Asd

Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis	Batten Disease
Ncl	Neuronal Ceroid-Lipofuscinoses
Lipofuscinosis, Ceroid, Neuronal	Juvenile Neuronal Ceroid Lipofuscinosis
Cerebromacular Dystrophy	Cerebromacular Degeneration
Ceroid-Lipofuscinosis	Ncl - [Neuronal Ceroid Lipofuscinosis]
Amaurotic Familial Idiocy	Amaurotic Idiocy
Amaurotic Idiot	Neuronal Lipofuscinosis
Pigmentary Retinal Lipoid Neuronal Heredodegeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03321	CTSA Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CTSA	RGD	RGD:1309070
Bos taurus	CTSA	VGNC	VGNC:27812
Canis familiaris	CTSA	VGNC	VGNC:39708
Mus musculus	CTSA	MGD	MGI:97748
Felis catus	CTSA	VGNC	VGNC:80077
Macaca mulatta	CTSA	VGNC	VGNC:71617
Others	CTSA	NCBI