PRKAR1A - protein kinase cAMP-dependent type I regulatory subunit alpha Gene

Also Known as CAR; CNC; CNC1; PKR1; TSE1; ADOHR; PPNAD1; PRKAR1; ACRDYS1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5573

About PRKAR1A

Cytogenetic location: 17q24.2 Genomic coordinates (GRCh38): 17:68,413,623-68,551,316 (from NCBI)

This gene has 24 transcripts (splice variants), 245 orthologues, 4 paralogues and is associated with 101 phenotypes. Ubiquitous expression in heart (RPKM 107.2), thyroid (RPKM 76.1) and 25 other tissues.

Summary

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013]

PRKAR1A Products (8)

mRNA	Protein	Name
NM_001276289.2	NP_001263218.1	cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a
NM_001276290.1	NP_001263219.1	cAMP-dependent protein kinase type I-alpha regulatory subunit isoform b
NM_001278433.2	NP_001265362.1	cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a
NM_001369389.1	NP_001356318.1	cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a
NM_001369390.1	NP_001356319.1	cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a
NM_002734.5	NP_002725.1	cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a
NM_212471.3	NP_997636.1	cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a
NM_212472.2	NP_997637.1	cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cAMP-dependent protein kinase inhibitor activity	IDA IDA: Inferred from direct assay	21812984	GOA
enables cAMP-dependent protein kinase regulator activity	IDA IDA: Inferred from direct assay	21812984	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11414803	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	25097019	GOA
enables protein kinase A catalytic subunit binding	IPI IPI: Inferred from physical interaction	17911601	GOA
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	21423175	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	17911601	GOA
involved in negative regulation of cAMP/PKA signal transduction	IDA IDA: Inferred from direct assay	21812984	GOA
acts upstream of negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	28159925	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with axoneme	IDA IDA: Inferred from direct assay	12475942	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17911601	GOA
colocalizes with immunological synapse	IDA IDA: Inferred from direct assay	17911601	GOA
part of nucleotide-activated protein kinase complex	IDA IDA: Inferred from direct assay	21812984	GOA
located in plasma membrane raft	IDA IDA: Inferred from direct assay	17911601	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	25097019	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKAR1A Protein Structure

RIIa

cNMP_binding

0
100
200
300
381 a.a.

Protein Preferred Names	Protein Names
cAMP-dependent protein kinase type I-alpha regulatory subunit	Carney complex type 1

PRKAR1A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PRKAR1A	P10644	AKAP7	Homo sapiens	O43687-2	Y2H Prey Pooling	32296183
Intra	PRKAR1A	P10644	AKAP7	Homo sapiens	O43687-2	Y2H Array	32296183
Intra	PRKAR1A	P10644	SET	Homo sapiens	Q01105	Display Tech	20195357
Intra	PRKAR1A	P10644	FAM153B	Homo sapiens	P0C7A2-2	Y2H Prey Pooling	32296183
Intra	PRKAR1A	P10644	FAM153B	Homo sapiens	P0C7A2-2	Y2H Array	32296183
Intra	PRKAR1A	P10644	CSTPP1	Homo sapiens	Q9H6J7-2	Validated Y2H	32296183
Intra	PRKAR1A	P10644	CSTPP1	Homo sapiens	Q9H6J7-2	Y2H Array	32296183
Intra	PRKAR1A	P10644	CSTPP1	Homo sapiens	Q9H6J7-2	Y2H Prey Pooling	32296183
Intra	PRKAR1A	P10644	DTX1	Homo sapiens	Q86Y01	Y2H Prey Pooling	32296183
Intra	PRKAR1A	P10644	DTX1	Homo sapiens	Q86Y01	Validated Y2H	32296183
Intra	PRKAR1A	P10644	DTX1	Homo sapiens	Q86Y01	Y2H Array	32296183
Intra	PRKAR1A	P10644	SPART	Homo sapiens	Q8N0X7	Y2H Array	32296183
Intra	PRKAR1A	P10644	SPART	Homo sapiens	Q8N0X7	Y2H Prey Pooling	32296183
Intra	PRKAR1A	P10644	SPART	Homo sapiens	Q8N0X7	Validated Y2H	32296183
Intra	PRKAR1A	P10644	PRKAR1B	Homo sapiens	P31321	Y2H Prey Pooling	32296183
Intra	PRKAR1A	P10644	PRKAR1B	Homo sapiens	P31321	Y2H Array	32296183
Intra	PRKAR1A	P10644	PRKAR1B	Homo sapiens	P31321	Anti Tag CoIP	31980649
Intra	PRKAR1A	P10644	PRKAR1B	Homo sapiens	P31321	Anti Tag CoIP	33961781
Intra	PRKAR1A	P10644	PRKAR1B	Homo sapiens	P31321	Anti Tag CoIP	28514442
Intra	PRKAR1A	P10644	PRKAR1B	Homo sapiens	P31321	Validated Y2H	32296183
Intra	PRKAR1A	P10644	RFC2	Homo sapiens	P35250	CoIP	15655353
Intra	PRKAR1A	P10644	RFC2	Homo sapiens	P35250	Pull Down	15655353
Intra	PRKAR1A	P10644	PRKACA	Homo sapiens	P17612	Y2H Prey Pooling	32296183
Intra	PRKAR1A	P10644	PRKACA	Homo sapiens	P17612	Validated Y2H	32296183
Intra	PRKAR1A	P10644	PRKACA	Homo sapiens	P17612	CoIP	15655353
Intra	PRKAR1A	P10644	PRKACA	Homo sapiens	P17612	Anti Tag CoIP	31980649
Intra	PRKAR1A	P10644	PRKACA	Homo sapiens	P17612	Anti Tag CoIP	24700472
Intra	PRKAR1A	P10644	PRKACA	Homo sapiens	P17612	Y2H Array	32296183
Intra	PRKAR1A	P10644	PRKACA	Homo sapiens	P17612	Anti Tag CoIP	33961781
Intra	PRKAR1A	P10644	PRKACA	Homo sapiens	P17612	Anti Bait CoIP	17353931
Intra	PRKAR1A	P10644	RSPH3	Homo sapiens	Q86UC2	Validated Y2H	32296183
Intra	PRKAR1A	P10644	RSPH3	Homo sapiens	Q86UC2	Y2H Array	32296183
Intra	PRKAR1A	P10644	RSPH3	Homo sapiens	Q86UC2	Y2H Prey Pooling	32296183
Intra	PRKAR1A	P10644	AKAP5	Homo sapiens	P24588	Y2H Array	32296183
Intra	PRKAR1A	P10644	AKAP5	Homo sapiens	P24588	Y2H Prey Pooling	32296183
Intra	PRKAR1A	P10644	AKAP5	Homo sapiens	P24588	Validated Y2H	32296183
Intra	PRKAR1A	P10644	ZBED1	Homo sapiens	O96006	Anti Tag CoIP	33961781
Intra	PRKAR1A	P10644	ZBED1	Homo sapiens	O96006	Anti Tag CoIP	28514442
Intra	PRKAR1A	P10644	ZBED1	Homo sapiens	O96006	Y2H	21900206
Intra	PRKAR1A	P10644	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Pooling	16189514
Intra	PRKAR1A	P10644	C2orf88	Homo sapiens	Q9BSF0	Y2H Prey Pooling	32296183
Intra	PRKAR1A	P10644	C2orf88	Homo sapiens	Q9BSF0	Validated Y2H	32296183
Intra	PRKAR1A	P10644	C2orf88	Homo sapiens	Q9BSF0	Y2H Array	32296183
Intra	PRKAR1A	P10644	C2orf88	Homo sapiens	Q9BSF0	Y2H Pooling	16189514
Intra	PRKAR1A	P10644	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859
Cross	PRKAR1A	P10644	p03259-2	Human adenovirus A	P03259-2	Y2H	11414803
Cross	PRKAR1A	P10644	p03259-2	Human adenovirus A	P03259-2	Imaging	11414803

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRKAR1A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71103	PRKAR1A Protein, Human (HEK293, His)	P10644 (E2-V381)	≥ 90%, as determined by reducing SDS-PAGE.

PRKAR1A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82006	PKA RI alpha Antibody (YA1751)	WB	Human, Rat
HY-P82006A	PKA RI alpha Antibody (YA1751)(PBS only)	WB	Human, Rat

Related Diseases

Diseases	Alias
Myxoma, Intracardiac	Atrial Myxoma, Familial Intracardiac Myxoma Familial Atrial Myxoma INTMYX
Acrodysostosis 1 With Or Without Hormone Resistance	ACRDYS1 Adohr Acrodysostosis 1, With Or Without Hormone Resistance Arkless-Graham Syndrome Maroteaux-Malamut Syndrome Acrodysostosis
Carney Complex, Type 1	Carney Syndrome Car Name Syndrome CNC1 Carney Myxoma-Endocrine Complex Myxoma, Spotty Pigmentation, And Endocrine Overactivity Lamb Syndrome Carney Complex 1 Carney Complex
Pigmented Nodular Adrenocortical Disease, Primary, 1	PPNAD1 Pigmented Micronodular Adrenocortical Disease, Primary, 1 Cushing Syndrome, Adrenal, Due To Ppnad1 Adrenocortical Nodular Dysplasia, Primary Primary Pigmented Nodular Adrenocortical Disease 1 Adrenal Cushing Syndrome Due To Ppnad1 Primary Pigmented Micronodular Adrenocortical Disease 1 Primary Pigmented Nodular Adrenocortical Disease-1 Adrenocortical Disease, Nodular, Pigmented, Primary, Type 1
Acrodysostosis	Acrodysplasia Arkless-Graham Syndrome Maroteaux-Malamut Syndrome Nasal Hypoplasia-Peripheral Dysostosis-Intellectual Disability Syndrome Peripheral Dysostosis-Nasal Hypoplasia-Intellectual Disability Syndrome
Carney Complex Variant	Carney Complex Carney Syndrome Carney Complex, Type 1 Lamb Syndrome Name Syndrome Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome Carney Complex - Trismus - Pseudocamptodactyly Syndrome Carney Complex, Type 2 Car Cnc1 Carney Myxoma-Endocrine Complex Myxoma - Spotty Pigmentation - Endocrine Overactivity Myxoma, Spotty Pigmentation, And Endocrine Overactivity Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome Carney Complex-Trismus-Pseudocamptodactyly Syndrome CACOV
Primary Pigmented Nodular Adrenocortical Disease	Ppnad Primary Pigmented Nodular Adrenal Dysplasia Pigmented Nodular Adrenocortical Disease, Primary, 2 Pigmented Nodular Adrenocortical Disease, Primary, 1
Amelogenesis Imperfecta Hypoplastic Type, Ig	Amelogenesis Imperfecta Nephrocalcinosis Amelogenesis Imperfecta And Nephrocalcinosis Absent Enamel, Nephrocalcinosis And Apparently Normal Calcium Metabolism Ers Enamel Renal Syndrome Generalized Enamel Hypoplasia And Renal Dysfunction Ai1g Enamel-Renal Syndrome
Amelogenesis Imperfecta, Type Ig	Enamel-Renal Syndrome Ers Amelogenesis Imperfecta Type 1g AI1G Enamel-Renal-Gingival Syndrome Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome Aigfs Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis Amelogenesis Imperfecta Type Ig Amelogenesis Imperfecta-Nephrocalcinosis Syndrome Amelogenesis Imperfecta 1g Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis Amelogenesis Imperfecta Nephrocalcinosis
Usher Syndrome, Type Iv	USH4 Usher Syndrome, Type 4 Usher Syndrome 4
Acrodysostosis With Multiple Hormone Resistance
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Lentigines	Lentigo
Arrhythmogenic Right Ventricular Dysplasia, Familial, 10	Arrhythmogenic Right Ventricular Dysplasia 10 ARVD10 Arrhythmogenic Right Ventricular Cardiomyopathy 10 Arvc10 Familial Arrhythmogenic Right Ventricular Dysplasia 10 Dysplasia, Ventricular, Right, Arrhythmogenic, Type 10
Multiple Endocrine Neoplasia	Men Multiple Endocrine Adenomatosis Multiple Endocrine Neoplasia Syndrome Adenomatosis, Familial Endocrine Endocrine Neoplasia, Multiple Familial Endocrine Adenomatosis Mea Multiple Endocrine Neoplasms Multiple Endocrine Neoplasia Type 1
Acth-Independent Cushing Syndrome	Adrenal Cushing Syndrome Adrenocorticotropic Hormone-Independent Cushing Syndrome Corticotropin-Independent Cushing Syndrome
Adrenal Cortical Adenoma	Adrenocortical Adenoma Adenoma Adrenocortical
Neurilemmoma	Schwannoma Benign Schwannoma Neurilemoma Peripheral Fibroblastoma Psammomatous Schwannoma Neurolemmoma Schwannomas
Hypocalcemia, Autosomal Dominant 1	Autosomal Dominant Hypocalcemia Autosomal Dominant Hypocalcemia 1 HYPOC1 Hypocalcemia, Autosomal Dominant Hypercalciuric Hypocalcemia Hypocalcemia, Autosomal Dominant, With Bartter Syndrome Familial Hypocalcemia Hypocalcemia, Familial Hypoc Adh Autosomal Dominant Hypoparathyroidism Familial Hypercalciuric Hypocalcemia Ad Hypocalcemia Autosomal Dominant Hypocalcemia With Bartter Syndrome Hypoparathyroidism - Autosomal Dominant Hypocalcemia
Conn'S Syndrome	Cushing Syndrome Hyperaldosteronism Primary Hyperaldosteronism Hypercortisolism Primary Aldosteronism Cushing'S Syndrome Adrenal Gland Hyperfunction Conn Syndrome Hyperadrenalism Ectopic Acth Syndrome Hyperadrenocorticism Cushing Disease Cushing'S Disease Adrenal Cortex Adenoma Corticotroph Pituitary Adenoma Pituitary Corticotroph Micro-Adenoma Pituitary-Dependent Cushing Syndrome Pituitary Acth Hypersecretion Acth Syndrome, Ectopic Acth-Secreting Pituitary Adenoma Adrenal Hyperfunction Resulting From Pituitary Acth Excess Ectopic Adrenocorticotropic Hormone Syndrome Nodular Primary Adrenocortical Dysplasia Pituitary Dependent Cushing Syndrome Pituitary Cushing Syndrome Pituitary-Dependant Cushing Syndrome Pituitary-Dependant Hypercortisolism Pituitary-Dependant Hypercortisolism Disorder Aldosteronism Primary Acth Syndrome Ectopic Adrenal Cushing'S Syndrome Adrenal Cortical Adenoma Cushing Syndrome Nos Cortisol Hypersecretion Corticoadrenal Hypersecretion Cushing Syndrome Secondary To Ectopic Acth-Secretion Ectopic Cushing Syndrome Hypercortisolism Due To Nonpituitary Tumour Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome Idiopathic Aldosteronism Aldosteronism Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia Primary Aldosteronism Due To Adrenal Hyperplasia
Breast Ductal Adenoma
Breast Adenoma	Ademoma - Breast
Sertoli Cell Tumor	Tubular Androblastoma
Hyperparathyroidism, Neonatal Severe	NSHPT Neonatal Severe Primary Hyperparathyroidism Nsph Nhpt Hyperparathyroidism, Neonatal Hyperparathyroidism, Neonatal Severe Primary Neonatal Severe Hyperparathyroidism Hyperparathyroidism, Severe, Neonatal Neonatal Hyperparathyroidism
Melanotic Neurilemmoma	Melanotic Schwannoma Pigmented Neurilemmoma Pigmented Schwannoma
Prolactinoma	Prolactin-Producing Pituitary Gland Adenoma Prolactin-Secreting Pituitary Adenoma Forbes-Albright Syndrome Lactotroph Adenoma Prl-Secreting Pituitary Adenoma Prloma Pituitary Lactotrophic Adenoma Familial Prolactinoma Pituitary Adenoma, Prolactin-Secreting Prolactinoma Of Pituitary Gland PSPA
Hyperparathyroidism	Hyperparathyroidism And Other Disorders Of Parathyroid Gland Parathyroid Hyperfunction Hpth - [Hyperparathyroidism] Parathyroid Gland Hyperfunction Parathyroid Glandular Hyperfunction
Growth Hormone Secreting Pituitary Adenoma	Somatotroph Adenoma Growth Hormone-Secreting Pituitary Adenoma Growth Hormone Producing Adenoma Of The Pituitary Growth Hormone Secreting Adenoma Of Pituitary
Thyroid Tumor
Hypoparathyroidism	Hypoparathyroidism, Idiopathic Parathyroid, Underactivity Of Syndrome With Hypoparathyroidism Deficiency Of Parathyroid Hormone Parathyroid Gland Insufficiency Parathyroid Insufficiency Hypoparathyroidism Due To Impaired Pth - [Parathyroid Hormone] Secretion
Primary Hyperparathyroidism	Familial Primary Hyperparathyroidism Hyperparathyroidism, Primary Hyperparathyroidism Primary Hypocalciuric Hypercalcemia, Familial, Type 1 Familial Benign Hypercalcemia Familial Hyperparathyroidism Parathyroid Enlargement
Multiple Endocrine Neoplasia, Type I	Multiple Endocrine Neoplasia Type 1 MEN1 Wermer Syndrome Multiple Endocrine Neoplasia 1 Multiple Endocrine Neoplasia, Type 1 Men I Endocrine Adenomatosis, Multiple Mea I Men Type I Wermer'S Syndrome Men1 Syndrome Multiple Endocrine Adenomatosis Endocrine Adenomatosis Multiple Men 1 Familial Multiple Endocrine Neoplasia Type I Neoplasia, Endocrine, Multiple, Type 1 Multiple Endocrine Neoplasia
Adrenal Adenoma	Adenoma Of The Adrenal Gland Adrenal Incidentaloma Adrenal Cortical Adenoma Adrenocortical Adenoma
Secondary Hyperparathyroidism	Hyperparathyroidism Secondary Hyperparathyroidism, Secondary Secondary Hyperparathyroidism Nec
Pseudohypoparathyroidism	Familial Pseudohypoparathyroidism Parathyroid Hormone Resistant Hypoparathyroidism Php - [Pseudohypoparathyroidism] Constitutional Chronic Hypocalcaemia
Adrenal Cortical Carcinoma	Adrenocortical Carcinoma Adrenal Cortex Carcinoma Carcinoma Of The Adrenal Cortex Acc Adrenocortical Cancer Carcinoma Adrenocortical
Adenoma	Acinar Cell Adenoma Adenomas Acinic Cell Adenoma
Heart Cancer	Malignant Neoplasm Of Heart Heart Neoplasm Cardiac Tumor Malignant Cardiac Tumor Tumour Of Heart Heart Neoplasms Cardiac Carcinoma
Pituitary Adenoma	Adenoma Of The Pituitary Gland Pituitary Adenomas Adenoma, Pituitary Pituitary Gland Adenoma Pituitary Neoplasms
Adrenal Cortex Disease	Adrenal Cortex Diseases
Parathyroid Adenoma	Adenoma Of Parathyroid Adenoma Of The Parathyroid Gland Parathyroid Gland Adenoma
Adrenal Carcinoma	Adrenal Cancer Adrenal Gland Cancer Malignant Neoplasm Of Adrenal Gland Adrenal Gland Neoplasms Carcinoma Of The Adrenal Gland Adrenal Neoplasm Malignant Adrenal Tumor Neoplasm Of Adrenal Gland Tumor Of The Adrenal Gland Adrenal Gland Neoplasm Adrenocortical Carcinoma Adrenal Gland Malignancy Suprarenal Cancer Malignant Neoplasm Of Suprarenal Gland Malignant Neoplasm Of Adrenal Gland, Unspecified Malignant Tumour Of Adrenal Gland Suprarenal Gland Cancer Primary Malignant Neoplasm Of Adrenal Gland
Dysostosis	Dysostoses
Acth-Independent Macronodular Adrenal Hyperplasia	Acth-Independent Macronodular Adrenocortical Hyperplasia Adrenocorticotropic Hormone-Independent Macronodular Adrenal Hyperplasia Corticotropin-Independent Macronodular Adrenal Hyperplasia Cushing Syndrome Due To Macronodular Adrenal Hyperplasia AIMAH1 Aimah Massive Macronodular Adrenocortical Disease Mmad Primary Macronodular Adrenal Hyperplasia Cushing Syndrome, Adrenal, Due To Aimah Primary Bilateral Macronodular Adrenal Hyperplasia Acth-Independent Macronodular Adrenal Hyperplasia 1 Acth-Independent Cushing Syndrome Adrenal Cushing Syndrome Due To Aimah Acth-Independent Macronodular Adrenal Hyperplasia 2
Pituitary Cancer	Pituitary Carcinoma Malignant Pituitary Neoplasm Malignant Tumor Of Pituitary Gland Neoplasm Of Pituitary Gland Pituitary Gland Cancer Pituitary Gland Neoplasm Pituitary Neoplasm Carcinoma Of The Pituitary Gland Neoplasm Of The Pituitary Gland Pituitary Neoplasms Malignant Neoplasm Of Pituitary Gland
Dicer1 Syndrome	Pleuro-Pulmonary Blastoma Familial Tumor Susceptibility Syndrome Pleuropulmonary Blastoma Familial Tumor Susceptibility Syndrome Ppb Familial Tumor Susceptibility Syndrome Dicer1-Related Pleuropulmonary Blastoma Cancer Predisposition Syndrome Pleuro-Pulmonary Blastoma Familial Tumor Susceptibility Dicer1-Related Pleuropulmonary Blastoma Pleuropulmonary Blastoma Familial Tumor And Dysplasia Syndrome Pleuropulmonary Blastoma Family Tumor Susceptibility Syndrome Ppbftds Doid:0081063
Peutz-Jeghers Syndrome	PJS Polyposis, Hamartomatous Intestinal Polyps-And-Spots Syndrome Lentiginosis, Perioral Periorificial Lentiginosis Syndrome Hamartomatous Intestinal Polyposis Hamartomatous Polyp Colonic Hamartomatous Polyp Gastric Peutz-Jeghers Polyp Peutz Jeghers Colon Polyp Peutz Jeghers Polyp Peutz-Jeghers Polyp Of Small Intestine Peutz-Jeghers Small Bowel Hamartoma Peutz Jeghers Polyposis Intestinal Polyposis-Cutaneous Pigmentation Syndrome Peutz-Jeghers Polyposis Polyposis, Intestinal, Ii Intestinal Hamartomatous Polyposis Peutz-Jeghers Polyp Peutz-Jeghers Polyp Of The Stomach Peutz Jehgers Polyp Peutz-Jeghers Polyps Of Small Bowel
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Thyroid Carcinoma, Familial Medullary	Medullary Thyroid Carcinoma Familial Medullary Thyroid Carcinoma MTC Medullary Thyroid Cancer Fmtc Mtc1 Thyroid Cancer, Medullary Thyroid Carcinoma, Medullary Familial Mtc Thyroid Carcinoma Medullary Carcinoma, Thyroid, Medullary, Familial Medullary Carcinoma Of Thyroid Medullary Carcinoma With Amyloid Stroma, Unspecified Site Medullary Carcinoma With Amyloid Stroma Of Thyroid
Mccune-Albright Syndrome	Mass Syndrome Polyostotic Fibrous Dysplasia MAS Fibrous Dysplasia Of Bone Albright Syndrome Mass Phenotype Overlap Connective Tissue Disease Mccune Albright Syndrome Osteitis Fibrosa Disseminata OCTD Albright'S Disease Pfd Pofd Albright'S Syndrome Mccune-Albright Syndrome, Somatic, Mosaic Albright'S Disease Of Bone Albright'S Syndrome With Precocious Puberty Albright-Mccune-Sternberg Syndrome Albright-Sternberg Syndrome Fibrous Dysplasia With Pigmentary Skin Changes And Precocious Puberty Gonadotropin-Independent Female-Limited Sexual Precocity Fibrous Dysplasia Polyostotic Fibrous Dysplasia, Polyostotic
Brachydactyly
Pseudohypoparathyroidism, Type Ia	Albright'S Hereditary Osteodystrophy Albright Hereditary Osteodystrophy Pseudohypoparathyroidism Type 1a PHP1A Albright Hereditary Osteodystrophy With Multiple Hormone Resistance Pseudohypoparathyroidism Ia AHO Pseudohypoparathyroidism With Albright Hereditary Osteodystrophy Pseudo-Pseudohypoparathyroidism Pseudohypoparathyroidism Type I A Php Ia Pseudopseudohypoparathyroidism Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance Pphp Pseudopseudo-Hypoparathyroidism Aho-Php Syndrome Ia Albright Hereditary Osteodystrophy-Php Syndrome Ia Pseudohypoparathyroidism 1a Pseudohypoparathyroidism
Multiple Endocrine Neoplasia, Type Iv	Multiple Endocrine Neoplasia Type 4 MEN4 Multiple Endocrine Neoplasia 4 Neoplasia, Endocrine, Multiple, Type Iv
Adrenal Gland Disease	Adrenal Gland Diseases Adrenal Gland Disorders
Pulmonary Plasma Cell Granuloma	Plasma Cell Granuloma, Pulmonary Granuloma, Plasma Cell, Pulmonary Lymphocytic Pseudotumor Of Lung Sclerosing Hemangiocytoma Of Lung
Hypertension And Brachydactyly Syndrome	Brachydactyly With Hypertension Bilginturan Syndrome HTNB Brachydactyly-Arterial Hypertension Syndrome Brachydactyly, Type E, With Short Stature And Hypertension Bilginturan Brachydactyly Brachydactyly Type E With Short Stature And Hypertension Type E Brachydactyly With Short Stature And Hypertension Brachydactyly Type E, With Short Stature And Hypertension Hypertension With Brachydactyly
Hormone Producing Pituitary Cancer	Growth Hormone Producing Pituitary Tumor Pituitary Tumors, Hormone Producing Somatotropinoma Growth Hormone-Producing Pituitary Gland Neoplasm
Basophil Adenoma	Adenoma, Basophil Pituitary Gland Basophilic Adenoma
Lissencephaly, X-Linked, 2	X-Linked Lissencephaly With Abnormal Genitalia Hydranencephaly With Abnormal Genitalia Xlag Xlisg X-Linked Lissencephaly With Ambiguous Genitalia LISX2 Lissencephaly, X-Linked 2 X-Linked Lissencephaly 2 X-Linked Lissencephaly-Corpus Callosum Agenesis-Genital Anomalies Syndrome Xlag Syndrome Lissencephaly, X-Linked, With Ambiguous Genitalia Xlis2 X-Linked Lissencephaly - Agenesis Of The Corpus Callosum - Genital Anomalies X-Linked Lissencephaly-Agenesis Of The Corpus Callosum-Genital Anomalies Syndrome Xlag Syndrome Lissencephaly X-Linked With Ambiguous Genitalia Lissencephaly, X-Linked, Type 2 Chromosome Xq26.3 Duplication Syndrome
Hypothyroidism, Congenital, Nongoitrous, 1	Tsh Resistance CHNG1 Hypothyroidism Due To Tsh Receptor Mutations Thyrotropin Resistance Thyroid-Stimulating Hormone Rtsh Hypothyroidism Due To Unresponsiveness To Thyrotropin Congenital Nongoitrous Hypothyroidism 1 Thyroid-Stimulating Hormone, Resistance To Hypothyroidism, Nonautoimmune Hypothyroidism, Congenital, Due To Tsh Resistance Hypothyroidism, Congenital, Non-Goitrous, 1 Congenital Hypothyroidism Due To Tsh Resistance Non-Autoimmune Hypothyroidism Thyroid-Stimulating Hormone Resistance Hypothyroidism, Congenital, Nongoitrous, Type 1 Hypothyroidism, Congenital, Nongoitrous, 3 Thyroid Hormone Resistance Syndrome
Pseudopseudohypoparathyroidism	PPHP Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance Normocalcemic Pseudohypoparathyroidism Aho-Pphp Syndrome Albright Hereditary Osteodystrophy-Pphp Syndrome Pseudohypoparathyroidism
Hyperpituitarism
Meningeal Melanocytoma	Leptomeningeal Melanocytoma Melanocytoma Of Meninges
Fibrolamellar Carcinoma	Fibrolamellar Hepatocellular Carcinoma Fhcc Fibrolamellar Hepatocarcinoma Hepatocellular Carcinoma, Fibrolamellar Oncocytic Hepatocellular Tumor Eosinophilic Glassy Cell Hepatoma Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis Fl-Hcc Fibrolamellar Oncocytic Hepatoma Hepatocellular Carcinoma With Increased Stromal Fibrosis Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma
Functioning Pituitary Adenoma	Secretory Adenoma Of The Pituitary Gland Endocrine Active Pituitary Adenoma Secreting Pituitary Adenoma Pituitary Adenoma, Functioning
Breast Benign Neoplasm	Benign Tumour Of Breast Benign Neoplasm Of Female Breast
Thoracic Benign Neoplasm	Benign Neoplasm Of Thorax
Arthrogryposis, Distal, Type 7	Hecht Syndrome Trismus-Pseudocamptodactyly Syndrome Distal Arthrogryposis Type 7 Dutch-Kentucky Syndrome DA7 Hecht-Beals Syndrome Mouth, Inability To Open Completely, And Short Finger-Flexor Tendons Mouth, Inability To Completely Open, And Short Finger-Flexor Tendons Arthrogryposis Distal Type 7 Trismus Pseudocamptodactyly Syndrome Arthrogryposis, Distal, 7
Sex Cord-Gonadal Stromal Tumor	Sex Cord-Gonadal Stromal Tumour Sex Cord Stromal Tumour Sex Cord-Stromal Neoplasm Specialized Gonadal Neoplasm Specialized Gonadal Tumor Specialized Gonadal Tumour Sex Cord-Gonadal Stromal Tumors Sex Cord-Stromal Tumor Malignant Testicular Sex Cord-Stromal Tumor Sex Cord Stromal Tumor Of Testis
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Acth-Secreting Pituitary Adenoma	Acth-Producing Pituitary Adenoma Corticotroph Adenoma Corticotropinoma Pituitary-Dependent Cushing'S Disease Adrenal Gland Hyperfunction Cushing Syndrome
Pituitary Gland Disease	Pituitary Diseases Pituitary Dysfunction Pituitary Disease Pituitary Deficiency Pituitary Disorders
Osseous Heteroplasia, Progressive	Progressive Osseous Heteroplasia POH Osteoma Cutis Familial Ectopic Ossification Ectopic Ossification Familial Type Ectopic Ossification Heterotopic Ossification Ectopic Ossification, Familial Cutaneous Ossification Myositis Ossificans Progressiva Osteodermia Osteosis Cutis Ossification Heterotopic Heteroplasia, Osseous, Progressive Fibrodysplasia Ossificans Progressiva
Cowden Syndrome 1	Bannayan-Riley-Ruvalcaba Syndrome Pten Hamartoma Tumor Syndrome Lhermitte-Duclos Disease Bannayan-Zonana Syndrome Phts Riley-Smith Syndrome Bzs Ruvalcaba-Myhre-Smith Syndrome Multiple Hamartoma Syndrome Rmss Brrs Dysplastic Gangliocytoma Of The Cerebellum CWS1 Cs Cd Mham Pten Hamartoma Tumor Syndrome With Granular Cell Tumor Macrocephaly Multiple Lipomas And Hemangiomata Bannayan-Ruvalcaba-Riley Syndrome Myhre-Riley-Smith Syndrome LDD Cerebelloparenchymal Disorder Vi Hamartoma Syndrome, Multiple Bbrs Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata Macrocephaly, Multiple Lipomas, And Hemangiomata Macrocephaly Pseudopapilledema And Multiple Hemangiomas Ruvalcaba -Myhre-Smith Syndrome Ruvalcaba-Myhre Syndrome Cowden Disease Macrocephaly Pseudopapilledema And Multiple Hemangiomata Cerebellar Granule Cell Hypertrophy And Megalencephaly Cpd6 Pten Hamartoma Tumor Syndromes Cowden Syndrome, Type 1
Endocrine Organ Benign Neoplasm
Neurilemmomatosis	Schwannomatosis Neurofibromatosis Type 3 Nf3 Neurilemmomatosis Congenital Cutaneous Neurinomatosis Congenital Cutaneous Neurilemmomatosis Multiple Neurilemmomas Multiple Schwannomas Neurilemmomatosis, Congenital Cutaneous Schwannomatosis 1 Neurofibromatosis 3 Mixed Central And Peripheral Neurofibromatosis Nf3 - [Neurofibromatosis Type 3]
Skin Tag	Fibroepithelial Polyp Fibroepithelial Polyp Of Skin Soft Fibroma Skin Tags Cutaneous Tag Gardner Fibroma Acrochordon Fibroma Molle
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Pseudohypoparathyroidism, Type Ib	Pseudohypoparathyroidism Type 1b PHP1B Pseudohypoparathyroidism Ib Pseudohypoparathyroidism Type Ib Php Ib Pseudohypoparathyroidism 1b
Li-Fraumeni Syndrome	Sarcoma Family Syndrome Of Li And Fraumeni Sbla Syndrome LFS Li-Fraumeni Familiar Cancer Susceptibility Syndrome Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome Lfs1 Li Fraumeni Syndrome Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome Lfl Sbla Syndrome Li-Fraumeni-Like Syndrome Li-Fraumeni Syndrome 1
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple
Beckwith-Wiedemann Syndrome	Wiedemann-Beckwith Syndrome BWS Exomphalos-Macroglossia-Gigantism Syndrome Emg Syndrome Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation Emg Abnormality Wbs Exomphalos Macroglossia Gigantism Syndrome Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation Macroglossia Exomphalos Gigantism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11112	PRKAR1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17722	Prkar1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24187	Prkar1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PRKAR1A	VGNC	VGNC:54342
Rattus norvegicus	PRKAR1A	RGD	RGD:3391
Macaca mulatta	PRKAR1A	VGNC	VGNC:99211
Bos taurus	PRKAR1A	VGNC	VGNC:33324
Felis catus	PRKAR1A	VGNC	VGNC:69050
Mus musculus	PRKAR1A	MGD	MGI:104878
Others	PRKAR1A	NCBI