DTX1 - deltex E3 ubiquitin ligase 1 Gene

Homo sapiens

Also known as hDx-1; RNF140

Gene ID: 1840 | Gene type: protein coding

About DTX1

Cytogenetic location: 12q24.13 Genomic coordinates (GRCh38): 12:113,056,730-113,098,025 (from NCBI)

This gene has 5 transcripts (splice variants), 197 orthologues and 4 paralogues. Broad expression in lymph node (RPKM 13.1), spleen (RPKM 9.7) and 18 other tissues.

Summary

Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq, Jul 2008]

DTX1 Products(1)

mRNA	Protein	Name
NM_004416.3	NP_004407.2	E3 ubiquitin-protein ligase DTX1

DTX1 Protein Structure

WWE

zf-RING_2

0
100
200
300
400
500
620 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase DTX1

RING-type E3 ubiquitin transferase DTX1

Related Diseases

Diseases

Alias

Familial Pityriasis Rubra Pilaris

Familial Prp

Pityriasis Rubra Pilaris--Familial Type

Pityriasis Rubra Pilaris

PRP	Devergie'S Disease
Prp - [Pityriasis Rubra Pilaris]

N1 Diffuse Large B-Cell Lymphoma

N1 Dlbcl

Doid:0081067

Arteriovenous Malformations Of The Brain

Cerebral Arteriovenous Malformation	Intracranial Arteriovenous Malformation
Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To	Intracranial Arteriovenous Malformations
Bavm	Cerebral Arteriovenous Malformations
Intracranial Hemorrhage In Brain Cerebrovascular Malformations	Arteriovenous Malformation Of The Brain, Somatic
Intracranial Avm	Arteriovenous Malformations Cerebral

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-126931	Dinophysistoxin 1		/	Unkown
HY-RS04038	DTX1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DTX1	RGD	RGD:1585380
Felis catus	DTX1	VGNC	VGNC:61648
Macaca mulatta	DTX1	VGNC	VGNC:108340
Mus musculus	DTX1	MGD	MGI:1352744
Bos taurus	DTX1	VGNC	VGNC:28236

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