AZGP1 - alpha-2-glycoprotein 1, zinc-binding Gene

Also Known as ZAG; ZA2G

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 563

About AZGP1

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:99,966,730-99,976,031 (from NCBI)

This gene has 6 transcripts (splice variants), 397 orthologues and 22 paralogues. Biased expression in salivary gland (RPKM 748.1), liver (RPKM 688.6) and 5 other tissues.

Summary

Involved in cell adhesion and detection of chemical stimulus involved in sensory perception of bitter taste. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

AZGP1 Products (1)

mRNA Protein Name
NM_001185.4 NP_001176.1 zinc-alpha-2-glycoprotein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16237761 GOA
Biological Process GO Annotation Evidence References Source
involved in cell adhesion IDA
IDA: Inferred from direct assay
9813179 GOA
involved in detection of chemical stimulus involved in sensory perception of bitter taste IDA
IDA: Inferred from direct assay
24248522 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
24248522 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AZGP1 Protein Structure

MHC_I

MHC_I: Class I Histocompatibility antigen, domains alpha 1 and 2 (26 - 201)

C1-set

C1-set: Immunoglobulin C1-set domain (215 - 291)

  • 0
  • 100
  • 200
  • 298 a.a.
Protein Preferred Names Protein Names

zinc-alpha-2-glycoprotein

  • Alpha-2-glycoprotein, zinc

AZGP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AZGP1 P25311 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
AZGP1 P25311 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
AZGP1 P25311 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AZGP1 Proteins

Cat. No. Product Name Accession Purity
HY-P70016 AZGP1 Protein, Human (HEK293, His) P25311 (Q21-S298) ≥ 95%, as determined by reducing SDS-PAGE.

AZGP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82358 Zinc Alpha 2 Glycoprotein Antibody (YA2103) WB, IHC-P, IP Human

Related Diseases

Diseases Alias
Breast Cyst

  • Cyst Of The Breast

  • Breast Cysts
Breast Disease

  • Breast Diseases
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01294 AZGP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18267 Azgp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24745 Azgp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus AZGP1 VGNC VGNC:26367
Canis familiaris AZGP1 VGNC VGNC:38327
Rattus norvegicus AZGP1 RGD RGD:2187
Felis catus AZGP1 VGNC VGNC:68915
Mus musculus AZGP1 MGD MGI:103163
Macaca mulatta AZGP1 VGNC VGNC:70201
Others AZGP1 NCBI