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PRPS2 - phosphoribosyl pyrophosphate synthetase 2 Gene

Also Known as PRSII

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5634

About PRPS2

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:12,791,412-12,824,222 (from NCBI)

This gene has 5 transcripts (splice variants), 302 orthologues and 4 paralogues. Broad expression in testis (RPKM 94.5), adrenal (RPKM 26.5) and 22 other tissues.

Summary

This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

PRPS2 Products (2)

mRNA	Protein	Name
NM_001039091.3	NP_001034180.1	ribose-phosphate pyrophosphokinase 2 isoform 1
NM_002765.5	NP_002756.1	ribose-phosphate pyrophosphokinase 2 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRPS2 Protein Structure

Pribosyltran_N

Pribosyl_synth

0
100
200
300
318 a.a.

Protein Preferred Names	Protein Names
ribose-phosphate pyrophosphokinase 2	PPRibP synthetase

PRPS2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PRPS2	P11908	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	PRPS2	P11908	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	PRPS2	P11908	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	PRPS2	P11908	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	PRPS2	P11908	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	PRPS2	P11908	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	PRPS2	P11908	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	PRPS2	P11908	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	PRPS2	P11908	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	PRPS2	P11908	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	25416956
Intra	PRPS2	P11908	PRPSAP1	Homo sapiens	Q14558	Y2H Prey Pooling	25416956
Intra	PRPS2	P11908	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	PRPS2	P11908	PRPSAP1	Homo sapiens	Q14558	Y2H Array	25416956
Intra	PRPS2	P11908	PRPS1	Homo sapiens	P60891	Anti Tag CoIP	33961781
Intra	PRPS2	P11908	PRPSAP1	Homo sapiens	Q14558	Validated Y2H	25416956
Intra	PRPS2	P11908	PRPSAP1	Homo sapiens	Q14558	Anti Tag CoIP	33961781
Intra	PRPS2	P11908	PRPS1	Homo sapiens	P60891	Y2H Array	31515488
Intra	PRPS2	P11908	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	31515488
Intra	PRPS2	P11908	PRPS1	Homo sapiens	P60891	Y2H Prey Pooling	25416956
Intra	PRPS2	P11908	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	PRPS2	P11908	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	25416956
Intra	PRPS2	P11908	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	PRPS2	P11908	TTR	Homo sapiens	P02766	Y2H Array	32814053
Intra	PRPS2	P11908	TTR	Homo sapiens	P02766	Validated Y2H	32814053
Intra	PRPS2	P11908	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
Intra	PRPS2	P11908	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	PRPS2	P11908	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	PRPS2	P11908	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	PRPS2	P11908	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	PRPS2	P11908	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRPS2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71108	PRPS2 Protein, Human (HEK293, His)	P11908-1 (P2-L318)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77156	PRPS2 Protein, Human (His)	P11908-1 (M1-L318)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Arts Syndrome	ARTS Mrxsarts Ataxia, Fatal X-Linked, With Deafness And Loss Of Vision Mrxs18 Lethal Ataxia With Deafness And Optic Atrophy Fatal X-Linked Ataxia With Deafness And Loss Of Vision Mental Retardation, X-Linked, Syndromic, Arts Type Mental Retardation, X-Linked, Syndromic 18 Syndromic X-Linked Mental Retardation 18 Syndromic X-Linked Mental Retardation Arts Type Lethal Ataxia-Deafness-Optic Atrophy X-Linked Fatal Ataxia With Deafness And Loss Of Vision Ataxia-Deafness-Optic Atrophy, Lethal Lethal Ataxia With Hearing Loss And Optic Atrophy Art
Charcot-Marie-Tooth Disease, X-Linked Recessive, 5	CMTX5 Rosenberg-Chutorian Syndrome Charcot-Marie-Tooth Disease X-Linked Recessive 5 Optic Atrophy, Polyneuropathy, And Deafness Charcot-Marie-Tooth Neuropathy X-Linked Recessive 5 Cmt5x X-Linked Charcot-Marie-Tooth Disease Type 5 Charcot-Marie-Tooth Neuropathy, X-Linked Recessive, 5 Optic Atrophy Polyneuropathy Deafness Optic Atrophy With Polyneuropathy And Deafness Charcot-Marie-Tooth Disease, X-Linked Recessive, Type 5
Deafness, X-Linked 1	DFNX1 Dfn2 Deafness, X-Linked 2, Sensorineural Congenital X-Linked Deafness 1 X-Linked Sensorineural Congenital Deafness 2 Deafness, X-Linked, 1 Congenital Sensorineural Deafness X-Linked 2 Deafness, X-Linked, Type 1
Childhood B-Cell Acute Lymphoblastic Leukemia	B-Cell Childhood Acute Lymphoblastic Leukemia
Phosphoribosylpyrophosphate Synthetase Superactivity	PRPS1 SUPERACTIVITY Prpp Synthetase Superactivity Gout, Prps-Related Prpp Synthetase Deficiency Prpp Synthetase Overactivity Prs Overactivity Prs Superactivity Mild Phosphoribosylpyrophosphate Synthetase Superactivity Mild Prpp Synthetase Superactivity Mild Prps1 Superactivity Severe Phosphoribosylpyrophosphate Synthetase Superactivity Severe Prpp Synthetase Superactivity Severe Prps1 Superactivity Prps-Related Gout Superactivity, Phosphoribosylpyrophosphate Synthetase
Charcot-Marie-Tooth Disease Type X
X-Linked Nonsyndromic Deafness	X-Linked Deafness Deafness, X-Linked
Retinitis Pigmentosa 19	RP19 Retinitis Pigmentosa-19 Retinitis Pigmentosa, Type 19
Syndromic X-Linked Intellectual Disability	X-Linked Syndromic Intellectual Disability
Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11220	PRPS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18836	Prps2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25328	Prps2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PRPS2	RGD	RGD:3415
Mus musculus	PRPS2	MGD	MGI:97776
Macaca mulatta	PRPS2	VGNC	VGNC:103849
Bos taurus	PRPS2	VGNC	VGNC:56950
Canis familiaris	PRPS2	VGNC	VGNC:45033
Others	PRPS2	NCBI