RNASE1 - ribonuclease A family member 1, pancreatic Gene

Homo sapiens

Also known as RAC1; RIB1; RNS1

Gene ID: 6035 | Gene type: protein coding

About RNASE1

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,801,228-20,802,844 (from NCBI)

This gene has 5 transcripts (splice variants), 109 orthologues and 12 paralogues. Broad expression in pancreas (RPKM 931.1), testis (RPKM 410.8) and 19 other tissues.

Summary

This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

RNASE1 Products(4)

mRNA	Protein	Name
NM_002933.5	NP_002924.1	ribonuclease pancreatic precursor
NM_198232.3	NP_937875.1	ribonuclease pancreatic precursor
NM_198234.3	NP_937877.1	ribonuclease pancreatic precursor
NM_198235.3	NP_937878.1	ribonuclease pancreatic precursor

RNASE1 Protein Structure

RnaseA

0
100
156 a.a.

Protein Preferred Names

Protein Names

ribonuclease pancreatic

HP-RNase

Recombinant RNASE1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71089	Rnase 1 Protein, Human (HEK293, His)	P07998 (K29-T156)	≥95%
HY-P71089Y	Rnase 1 Protein, Human (HEK293, His, solution)	P07998 (K29-T156)	≥95%

Related Diseases

Diseases

Alias

Mesothelioma, Malignant

Malignant Mesothelioma	Pleural Mesothelioma
MESOM	Mesothelioma, Somatic
Advanced Malignant Mesothelioma	Asbestos-Related Malignant Mesothelioma
Diffuse Malignant Mesothelioma	Malignant Tumor Of Mesothelium
Malignant Mesothelioma, Susceptibility To	Mesothelioma Diffuse Malignant
Mesothelioma	Malignant Pleural Mesothelioma

Lynch Syndrome

Hereditary Nonpolyposis Colon Cancer	Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Carcinoma	Hereditary Nonpolyposis Colorectal Neoplasms
Familial Nonpolyposis Colon Cancer	Hnpcc
Coca 1	Hereditary Defective Mismatch Repair Syndrome
Hereditary Non-Polyposis Colon Cancer	Hereditary Non-Polyposis Colon Cancer Syndrome
Hereditary Non-Polyposis Colorectal Cancer	Hereditary Non-Polyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colon Cancer Syndrome	Hereditary Nonpolyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colorectal Neoplasm	Hnpcc - Hereditary Nonpolyposis Colon Cancer
Cancer Family Syndrome	Familial Nonpolyposis Colorectal Cancer
Colon Cancer, Familial Nonpolyposis	Colorectal Neoplasms, Hereditary Nonpolyposis
Cancer, Colorectal, Nonpolyposis, Hereditary	Colorectal Cancer, Hereditary Nonpolyposis, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12018	RNASE1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RNASE1	VGNC	VGNC:76700
Mus musculus	RNASE1	MGD	MGI:97919
Rattus norvegicus	RNASE1	RGD	RGD:3574
Others	RNASE1	NCBI

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