RNASE1 - ribonuclease A family member 1, pancreatic Gene

Also Known as RAC1; RIB1; RNS1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6035

About RNASE1

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,801,228-20,802,844 (from NCBI)

This gene has 5 transcripts (splice variants), 109 orthologues and 12 paralogues. Broad expression in pancreas (RPKM 931.1), testis (RPKM 410.8) and 19 other tissues.

Summary

This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded Endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine Bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

RNASE1 Products (4)

mRNA Protein Name
NM_002933.5 NP_002924.1 ribonuclease pancreatic precursor
NM_198232.3 NP_937875.1 ribonuclease pancreatic precursor
NM_198234.3 NP_937877.1 ribonuclease pancreatic precursor
NM_198235.3 NP_937878.1 ribonuclease pancreatic precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables RNA nuclease activity IDA
IDA: Inferred from direct assay
9826755 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17350650 GOA
Biological Process GO Annotation Evidence References Source
NOT involved in defense response to virus IDA
IDA: Inferred from direct assay
9826755 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNASE1 Protein Structure

RnaseA

RnaseA: Pancreatic ribonuclease (30 - 149)

  • 0
  • 100
  • 156 a.a.
Protein Preferred Names Protein Names

ribonuclease pancreatic

  • HP-RNase

RNASE1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RNASE1 P07998 RNH1 Homo sapiens P13489
Lumier
32814053
Intra
RNASE1 P07998 RNH1 Homo sapiens P13489
Affinity Techniques
17350650
Intra
RNASE1 P07998 RNH1 Homo sapiens P13489
Anti Tag CoIP
33961781
Intra
RNASE1 P07998 RNH1 Homo sapiens P13489
Lumier
29997244
Intra
RNASE1 P07998 RNH1 Homo sapiens P13489
Anti Tag CoIP
28514442
Intra
RNASE1 P07998 TRIM7 Homo sapiens Q9C029
Y2H Array
32296183
Intra
RNASE1 P07998 TRIM7 Homo sapiens Q9C029
Y2H Prey Pooling
32296183
Intra
RNASE1 P07998 TRIM7 Homo sapiens Q9C029
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RNASE1 Proteins

Cat. No. Product Name Accession Purity
HY-P71089 Rnase 1 Protein, Human (HEK293, His) P07998 (K29-T156) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Mesothelioma, Malignant

  • Malignant Mesothelioma

  • Pleural Mesothelioma

  • MESOM

  • Mesothelioma, Somatic

  • Advanced Malignant Mesothelioma

  • Asbestos-Related Malignant Mesothelioma

  • Diffuse Malignant Mesothelioma

  • Malignant Tumor Of Mesothelium

  • Malignant Mesothelioma, Susceptibility To

  • Mesothelioma Diffuse Malignant

  • Mesothelioma

  • Malignant Pleural Mesothelioma
Lynch Syndrome

  • Hereditary Nonpolyposis Colon Cancer

  • Hereditary Nonpolyposis Colorectal Cancer

  • Hereditary Nonpolyposis Colorectal Carcinoma

  • Hereditary Nonpolyposis Colorectal Neoplasms

  • Familial Nonpolyposis Colon Cancer

  • Hnpcc

  • Coca 1

  • Hereditary Defective Mismatch Repair Syndrome

  • Hereditary Non-Polyposis Colon Cancer

  • Hereditary Non-Polyposis Colon Cancer Syndrome

  • Hereditary Non-Polyposis Colorectal Cancer

  • Hereditary Non-Polyposis Colorectal Cancer Syndrome

  • Hereditary Nonpolyposis Colon Cancer Syndrome

  • Hereditary Nonpolyposis Colorectal Cancer Syndrome

  • Hereditary Nonpolyposis Colorectal Neoplasm

  • Hnpcc - Hereditary Nonpolyposis Colon Cancer

  • Cancer Family Syndrome

  • Familial Nonpolyposis Colorectal Cancer

  • Colon Cancer, Familial Nonpolyposis

  • Colorectal Neoplasms, Hereditary Nonpolyposis

  • Cancer, Colorectal, Nonpolyposis, Hereditary

  • Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12018 RNASE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20590 Rnase1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27098 Rnase1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RNASE1 VGNC VGNC:76700
Mus musculus RNASE1 MGD MGI:97919
Rattus norvegicus RNASE1 RGD RGD:3574
Others RNASE1 NCBI