RRAS - RAS related Gene

Also Known as R-Ras

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6237

About RRAS

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,635,292-49,640,143 (from NCBI)

This gene has 2 transcripts (splice variants), 175 orthologues, 35 paralogues and is associated with 3 phenotypes. Ubiquitous expression in fat (RPKM 75.3), lung (RPKM 63.7) and 23 other tissues.

Summary

The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015]

RRAS Products (1)

mRNA	Protein	Name
NM_006270.5	NP_006261.1	ras-related protein R-Ras

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables GDP binding	IDA IDA: Inferred from direct assay	16773572	GOA
enables GDP binding	IMP IMP: Inferred from mutant phenotype	24705357	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	16773572	GOA
enables GTPase activity	IMP IMP: Inferred from mutant phenotype	24705357	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17474147	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	23209302	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in face morphogenesis	IMP IMP: Inferred from mutant phenotype	24705357	GOA
involved in leukocyte differentiation	IMP IMP: Inferred from mutant phenotype	24705357	GOA
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	21393242	GOA
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	22825554	GOA
involved in positive regulation of endothelial cell-matrix adhesion via fibronectin	IMP IMP: Inferred from mutant phenotype	22825554	GOA
involved in positive regulation of vasculogenesis	IMP IMP: Inferred from mutant phenotype	22825554	GOA
involved in regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	24705357	GOA
involved in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	24705357	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RRAS Protein Structure

Ras

0
100
200
218 a.a.

Protein Preferred Names	Protein Names
ras-related protein R-Ras	oncogene RRAS

RRAS Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RRAS	P10301	RAP1GDS1	Homo sapiens	P52306-5	Validated Y2H	32296183
Intra	RRAS	P10301	NCK1	Homo sapiens	P16333	Peptide Array	17474147

Cross: Cross-species interaction Intra: Intraspecies interaction

RRAS Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83467	RRAS Antibody (YA3212)	WB	Human
HY-P83467A	RRAS Antibody (YA3212)(PBS only)	WB	Human

Related Diseases

Diseases	Alias
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome
Melnick-Needles Syndrome	MNS Melnick-Needles Osteodysplasty Osteodysplasty Of Melnick And Needles Osteochondrodysplasias
Noonan Syndrome With Multiple Lentigines	Leopard Syndrome Multiple Lentigines Syndrome Moynahan Syndrome Cardiomyopathic Lentiginosis Progressive Cardiomyopathic Lentiginosis Cardio-Cutaneous Syndrome Lentiginosis Profusa Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome Generalized Lentiginosis Gorlin Syndrome Ii Lentiginosis Profusa Syndrome Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes Diffuse Lentiginosis Nsml Familial Multiple Lentigines Syndrome Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type Progressive Cardiomyopathic Lentiginosis Syndrome Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan
Cardiofaciocutaneous Syndrome 1	Cardiofaciocutaneous Syndrome Cfc Syndrome Cardio-Facio-Cutaneous Syndrome CFC1 Cfcs Cardio-Facial-Cutaneous Syndrome Congenital Heart Defects Characteristic Facial Appearance Ectodermal Abnormalities And Growth Failure Cardiofaciocutaneous Syndrome, Type 1
Costello Syndrome	Faciocutaneoskeletal Syndrome Fcs Syndrome Congenital Myopathy With Excess Of Muscle Spindles CSTLO CMEMS Fcss Myopathy, Congenital, With Excess Of Muscle Spindles
Pulmonary Valve Disease	Pulmonary Valve Disorder
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Neurofibromatosis-Noonan Syndrome	NFNS Neurofibromatosis Type 1 Neurofibromatosis With Noonan Phenotype Nf1 Von Recklinghausen Disease Neurofibromatosis Type 1-Noonan Syndrome Noonan Neurofibromatosis Syndrome Recklinghausen'S Disease Noonan-Neurofibromatosis Syndrome Fibromatosis Multiple Non Ossifying Disseminated Nonossifying Fibromas In Association With Cafe-Au-Lait Spots Jaffe Campanacci Syndrome Type 1 Neurofibromatosis Neurofibromatosis 1 Peripheral Neurofibromatosis Recklinghausen Disease, Nerve Jaffe-Campanacci Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-128574	D927	Activator	99.46%	Unkown
HY-RS12281	RRAS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12280	RRAS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22313	Rras Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22789	Rras2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28835	Rras Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29303	Rras2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RRAS	VGNC	VGNC:64771
Mus musculus	RRAS	MGD	MGI:98179
Macaca mulatta	RRAS	VGNC	VGNC:76937
Bos taurus	RRAS	VGNC	VGNC:49146
Rattus norvegicus	RRAS	RGD	RGD:1311443
Canis familiaris	RRAS	VGNC	VGNC:49028
Others	RRAS	NCBI