Izumo1r - IZUMO1 receptor, JUNO Gene

Also Known as Juno; Folr4; Folbp3; 0910001L11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 64931

Summary

Enables signaling receptor activity and signaling receptor binding activity. Involved in cell adhesion; fusion of sperm to egg plasma membrane involved in single fertilization; and sperm-egg recognition. Predicted to be located in membrane. Predicted to be anchored component of external side of plasma membrane. Is expressed in several structures, including adrenal gland; gonad; gut; hemolymphoid system gland; and integumental system. Orthologous to human IZUMO1R (IZUMO1 receptor, JUNO). [provided by Alliance of Genome Resources, Apr 2022]

Izumo1r Products (2)

mRNA Protein Name
NM_022888.3 NP_075026.1 sperm-egg fusion protein Juno isoform 1 precursor
NM_176807.5 NP_789777.1 sperm-egg fusion protein Juno isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
NOT enables folic acid binding IMP
IMP: Inferred from mutant phenotype
24739963 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
24739963 MGI
enables protein binding involved in heterotypic cell-cell adhesion IDA
IDA: Inferred from direct assay
24739963 MGI
enables signaling receptor activity IPI
IPI: Inferred from physical interaction
24739963 MGI
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
27416963 MGI
Biological Process GO Annotation Evidence References Source
involved in cell adhesion IDA
IDA: Inferred from direct assay
27416963 MGI
involved in cell adhesion IMP
IMP: Inferred from mutant phenotype
24739963 MGI
involved in fusion of sperm to egg plasma membrane involved in single fertilization IDA
IDA: Inferred from direct assay
24739963 MGI
involved in fusion of sperm to egg plasma membrane involved in single fertilization IMP
IMP: Inferred from mutant phenotype
24739963 MGI
involved in single fertilization IDA
IDA: Inferred from direct assay
27416963 MGI
involved in single fertilization IMP
IMP: Inferred from mutant phenotype
24739963 MGI
involved in sperm-egg recognition IDA
IDA: Inferred from direct assay
24739963 MGI
involved in sperm-egg recognition IMP
IMP: Inferred from mutant phenotype
24739963 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sperm-egg fusion protein Juno

  • FR-delta

  • IZUMO1 receptor protein JUNO

  • folate receptor 4 (delta)

  • folate receptor delta

  • folate-binding protein 3

  • probable folate receptor delta

Recombinant Izumo1r Proteins

Cat. No. Product Name Accession Purity
HY-P77938 FOLR4 Protein, Mouse (HEK293, His) Q9EQF4-1 (G20-G222) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07005 IZUMO1R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21242 Izumo1r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27759 Izumo1r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Izumo1r NCBI NCBI:390243