Alas1 - 5'-aminolevulinate synthase 1 Gene

Also Known as ALAS; ALA-S; ALAS-H; ALAS-N

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 65155

Summary

Enables 5-aminolevulinate synthase activity. Involved in several processes, including cellular response to Insulin stimulus; response to herbicide; and response to nickel cation. Located in mitochondrion. Biomarker of porphyria and pulmonary hypertension. Orthologous to human ALAS1 (5'-aminolevulinate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]

Alas1 Products (1)

mRNA Protein Name
NM_024484.3 NP_077810.2 5-aminolevulinate synthase, non-specific, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 5-aminolevulinate synthase activity IDA
IDA: Inferred from direct assay
3182776 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
11716532 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
11368315 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
17761694 RGD
involved in response to cobalt ion IEP
IEP: Inferred from expression pattern
818637 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
18472004 RGD
involved in response to gonadotropin IEP
IEP: Inferred from expression pattern
19467246 RGD
involved in response to herbicide IEP
IEP: Inferred from expression pattern
12180188 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
9849899 RGD
involved in response to nickel cation IEP
IEP: Inferred from expression pattern
925603 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
17537461 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18657588 RGD
involved in response to platinum ion IEP
IEP: Inferred from expression pattern
925603 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
818637 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

5-aminolevulinate synthase, non-specific, mitochondrial

  • 5-aminolevulinate synthase 1

  • 5-aminolevulinate synthase, nonspecific, mitochondrial

  • 5-aminolevulinic acid synthase 1

  • aminolevulinate, delta-, synthase 1

  • aminolevulinic acid synthase 1

  • delta-ALA synthase 1

  • delta-ALA synthetase

  • delta-aminolevulinate

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-132610A Givosiran sodium 98.71% Unkown
HY-132610 Givosiran 96.95% Unkown

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00554 ALAS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17599 Alas1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24059 Alas1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Alas1 NCBI NCBI:211