TSPAN7 - tetraspanin 7 Gene

Also Known as A15; MXS1; CD231; MRX58; CCG-B7; TM4SF2; XLID58; TALLA-1; TM4SF2b; DXS1692E

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7102

About TSPAN7

Cytogenetic location: Xp11.4 Genomic coordinates (GRCh38): X:38,561,542-38,688,918 (from NCBI)

This gene has 8 transcripts (splice variants), 272 orthologues, 32 paralogues and is associated with 3 phenotypes. Broad expression in brain (RPKM 306.6), adrenal (RPKM 70.3) and 14 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked cognitive disability and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. [provided by RefSeq, Jul 2008]

TSPAN7 Products (1)

mRNA	Protein	Name
NM_004615.4	NP_004606.2	tetraspanin-7

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSPAN7 Protein Structure

Tetraspannin

0
100
200
249 a.a.

Protein Preferred Names	Protein Names
tetraspanin-7	CD231 antigen

TSPAN7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	TSPAN7	P41732	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	TSPAN7	P41732	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	TSPAN7	P41732	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	TSPAN7	P41732	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	TSPAN7	P41732	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	TSPAN7	P41732	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	TSPAN7	P41732	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	TSPAN7	P41732	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	TSPAN7	P41732	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	TSPAN7	P41732	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	TSPAN7	P41732	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	TSPAN7	P41732	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TSPAN7 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P77497	TM4SF2/TSPAN7 Protein, Human (HEK293, His)	AAH18036.1 (R113-M213)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, X-Linked 58	XLID58 Mrx58 Mental Retardation, X-Linked 58
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability
Non-Syndromic X-Linked Intellectual Disability 58	Mrx58
Syndromic X-Linked Intellectual Disability	X-Linked Syndromic Intellectual Disability
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Syndromic Intellectual Disability
Non-Syndromic X-Linked Intellectual Disability 91	Mrx91
Non-Syndromic X-Linked Intellectual Disability 106	Mrx106 X-Linked Mental Retardation 106
Non-Syndromic X-Linked Intellectual Disability 98	Mrx98 X-Linked Mental Retardation 98
Non-Syndromic X-Linked Intellectual Disability 9	Mrx44 Mrx9 X-Linked Mental Retardation 44
Syndromic X-Linked Intellectual Disability Type 10	Hsd10 Deficiency, Atypical Type Hsd10 Disease, Atypical Type X-Linked Intellectual Disability-Choreoathetosis-Abnormal Behavior Syndrome Mrxs10 Mental Retardation, X-Linked, Syndromic 10
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome
Benign Epilepsy With Centrotemporal Spikes	Rolandic Epilepsy Benign Rolandic Epilepsy Epilepsy, Rolandic Bcects Benign Childhood Epilepsy With Centrotemporal Spike Sylvan Seizures Becrs Bects Bre Benign Epilepsy Of Childhood With Centrotemporal Spikes Benign Familial Epilepsy Of Childhood With Rolandic Spikes Centrotemporal Epilepsy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS15173	TSPAN7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17860	Tspan7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24329	Tspan7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TSPAN7	MGD	MGI:1298407
Rattus norvegicus	TSPAN7	RGD	RGD:1589725
Others	TSPAN7	NCBI