TNNC1 - troponin C1, slow skeletal and cardiac type Gene

Also Known as TNC; TN-C; TNNC; CMD1Z; CMH13

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7134

About TNNC1

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:52,451,100-52,454,041 (from NCBI)

This gene has 3 transcripts (splice variants), 207 orthologues, 1 paralogue and is associated with 5 phenotypes. Restricted expression toward heart (RPKM 1964.8).

Summary

Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with Myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]

TNNC1 Products (1)

mRNA	Protein	Name
NM_003280.3	NP_003271.1	troponin C, slow skeletal and cardiac muscles

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	12840750	GOA
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	7957210	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10806205	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	18092822	GOA
enables troponin I binding	IDA IDA: Inferred from direct assay	18092822	GOA
enables troponin I binding	IPI IPI: Inferred from physical interaction	7957210	GOA
enables troponin T binding	IPI IPI: Inferred from physical interaction	8205619	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cardiac muscle contraction	IDA IDA: Inferred from direct assay	25771144	GOA
involved in cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	15542288	GOA
involved in regulation of muscle contraction	IDA IDA: Inferred from direct assay	18092822	GOA
involved in ventricular cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	15542288	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of cardiac Troponin complex	IDA IDA: Inferred from direct assay	25771144	GOA
part of troponin complex	IDA IDA: Inferred from direct assay	10850966	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNNC1 Protein Structure

EF-hand_8

EF-hand_7

0
100
161 a.a.

Protein Preferred Names	Protein Names
troponin C, slow skeletal and cardiac muscles	cardiac troponin C

TNNC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TNNC1	P63316	TNNI3	Homo sapiens	P19429	X-Ray Diffraction	12840750
Intra	TNNC1	P63316	TNNI2	Homo sapiens	P48788	NMR	24333682

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TNNC1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71372	Troponin C/TNNC1 Protein, Human (His, solution)	P63316 (M1-E161)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P71372A	Troponin C/TNNC1 Protein, Human (N-His)	P63316 (M1-E161)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Cardiomyopathy, Familial Hypertrophic, 13	Hypertrophic Cardiomyopathy 13 CMH13 Cardiomyopathy, Hypertrophic, 13 Cardiomyopathy Familial Hypertrophic 13 Cardiomyopathy, Familial Hypertrophic 13 Cardiomyopathy, Hypertrophic, Familial, Type 13
Cardiomyopathy, Dilated, 1z	CMD1Z Dilated Cardiomyopathy 1z Cardiomyopathy, Dilated 1z Cardiomyopathy, Dilated, Type 1z
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Familial Isolated Dilated Cardiomyopathy	Familial Or Idiopathic Dilated Cardiomyopathy
Cardiomyopathy, Dilated, 1e	Left Ventricular Noncompaction 9 Left Ventricular Noncompaction 5 Dilated Cardiomyopathy 1e Dilated Cardiomyopathy 1s CMD1E Cdcd2 Cardiomyopathy, Dilated, 1y CMD1Y Cardiomyopathy, Dilated, 1s CMD1S Dilated Cardiomyopathy 1y Dilated Cardiomyopathy With Conduction Defect 2 Dilated Cardiomyopathy With Conduction Disorder And Arrhythmia Cardiomyopathy, Dilated, With Conduction Disorder And Arrhythmia Cardiomyopathy, Dilated, With Conduction Defect 2 Cardiomyopathy Dilated With Conduction Defect Type 2 Cardiomyopathy, Dilated 1e Cardiomyopathy, Dilated 1s Cardiomyopathy, Dilated 1y Left Ventricular Non-Compaction 5 LVNC5 Left Ventricular Non-Compaction 9 LVNC9 Cardiomyopathy, Dilated, Type 1e Cardiomyopathy, Dilated, Type 1s Cardiomyopathy, Dilated, Type 1y
Cardiomyopathy, Dilated, 1ee	Dilated Cardiomyopathy 1ee CMD1EE Cardiomyopathy, Dilated 1ee Cardiomyopathy, Dilated, Type 1ee
Restrictive Cardiomyopathy	Familial Restrictive Cardiomyopathy Cardiomyopathy, Restrictive Cardiomyopathy, Constrictive Primary Restrictive Cardiomyopathy Rcm Cardiomyopathy Restrictive
Cardiomyopathy, Familial Hypertrophic, 26	Hypertrophic Cardiomyopathy 26 CMH26 Cardiomyopathy, Familial Restrictive 5 Cardiomyopathy, Familial Restrictive, 5 Cardiomyopathy Familial Hypertrophic 26 Cardiomyopathy, Familial Hypertrophic 26 RCM5
Cardiomyopathy, Familial Hypertrophic, 1	Asymmetric Septal Hypertrophy Familial Hypertrophic Cardiomyopathy Hypertrophic Cardiomyopathy 1 CMH1 Hypertrophic Cardiomyopathy 19 CMH Ventricular Hypertrophy, Hereditary Ash Hypertrophic Subaortic Stenosis, Idiopathic Cardiomyopathy, Familial Hypertrophic Cardiomyopathy, Hypertrophic, 1, Digenic Cardiomyopathy, Familial Hypertrophic 1 Hcm Hereditary Ventricular Hypertrophy Idiopathic Hypertrophic Subaortic Stenosis Hypertrophic Cardiomyopathy Cardiomyopathy, Hypertrophic, Familial Cardiomyopathy, Hypertrophic, 1 Familial Asymmetric Septal Hypertrophy Heritable Hypertrophic Cardiomyopathy Fhc Cardiomyopathy, Hypertrophic, Familial, Type 1
Hemochromatosis, Type 2b	Hemochromatosis Type 2b HFE2B Hemochromatosis 2b
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14848	TNNC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14852	TNNI3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19041	Tnnc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25531	Tnnc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TNNC1	VGNC	VGNC:78602
Canis familiaris	TNNC1	VGNC	VGNC:47686
Bos taurus	TNNC1	VGNC	VGNC:36189
Mus musculus	TNNC1	MGD	MGI:98779
Felis catus	TNNC1	VGNC	VGNC:66425
Rattus norvegicus	TNNC1	RGD	RGD:1309921
Others	TNNC1	NCBI