UQCRH - ubiquinol-cytochrome c reductase hinge protein Gene

Also Known as QCR6; UQCR8; MC3DN11

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7388

About UQCRH

Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:46,303,698-46,316,776 (from NCBI)

This gene has 5 transcripts (splice variants), 232 orthologues and 1 paralogue. Ubiquitous expression in heart (RPKM 164.7), colon (RPKM 117.2) and 25 other tissues.

Summary

Predicted to enable ubiquinol-cytochrome-c reductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

UQCRH Products (3)

mRNA Protein Name
NM_001297565.2 NP_001284494.1 cytochrome b-c1 complex subunit 6, mitochondrial isoform 2 precursor
NM_001297566.2 NP_001284495.1 cytochrome b-c1 complex subunit 6, mitochondrial isoform 3 precursor
NM_006004.4 NP_005995.2 cytochrome b-c1 complex subunit 6, mitochondrial isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables ubiquinol-cytochrome-c reductase activity IMP
IMP: Inferred from mutant phenotype
34750991 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
28844695 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UQCRH Protein Structure

UCR_hinge

UCR_hinge: Ubiquinol-cytochrome C reductase hinge protein (27 - 91)

  • 0
  • 91 a.a.
Protein Preferred Names Protein Names

cytochrome b-c1 complex subunit 6, mitochondrial

  • complex III subunit 6

UQCRH Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UQCRH P07919 ENTREP3 Homo sapiens Q96H71
Y2H Array
25416956
Intra
UQCRH P07919 RNF24 Homo sapiens Q9Y225
Validated Y2H
25416956
Intra
UQCRH P07919 RNF24 Homo sapiens Q9Y225
Y2H Prey Pooling
25416956
Intra
UQCRH P07919 NDFIP1 Homo sapiens Q9BT67
Validated Y2H
32296183
Intra
UQCRH P07919 NDFIP1 Homo sapiens Q9BT67
Y2H Array
32296183
Intra
UQCRH P07919 NDFIP1 Homo sapiens Q9BT67
Y2H Prey Pooling
32296183
Intra
UQCRH P07919 PRRG1 Homo sapiens O14668
Y2H Array
32296183
Intra
UQCRH P07919 PRRG1 Homo sapiens O14668
Y2H Prey Pooling
32296183
Intra
UQCRH P07919 NDFIP2 Homo sapiens Q9NV92
Y2H Prey Pooling
32296183
Intra
UQCRH P07919 NDFIP2 Homo sapiens Q9NV92
Validated Y2H
32296183
Intra
UQCRH P07919 NDFIP2 Homo sapiens Q9NV92
Y2H Array
32296183
Intra
UQCRH P07919 ARL8A Homo sapiens Q96BM9
Validated Y2H
25416956
Intra
UQCRH P07919 ARL8A Homo sapiens Q96BM9
Validated Y2H
32296183
Intra
UQCRH P07919 ARL8A Homo sapiens Q96BM9
Y2H Array
25416956
Intra
UQCRH P07919 ARL8A Homo sapiens Q96BM9
Y2H Array
32296183
Intra
UQCRH P07919 ARL8A Homo sapiens Q96BM9
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UQCRH Proteins

Cat. No. 상품명 Accession Purity
HY-P71088 UQCRH Protein, Human (GST) P07919 (M1-K91) ≥ 90%, as determined by reducing SDS-PAGE.

UQCRH Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P810752 UQCRH Antibody (YA9995) WB, ICC/IF Human, Rat

Related Diseases

Diseases Alias
Fibroosseous Pseudotumor Of Digits

  • Fibroosseous Digital Pseudotumor

  • Fibroosseous Pseudotumor Of The Digits
Non-Syndromic X-Linked Intellectual Disability 1

  • Mrx1

  • Mrx18

  • Mrx78

  • X-Linked Mental Retardation 1/78

  • X-Linked Mental Retardation 18
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS15502 UQCRH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20126 Uqcrh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26630 Uqcrh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus UQCRH MGD MGI:1913826
Rattus norvegicus UQCRH RGD RGD:1305987