Srebf1 - sterol regulatory element binding transcription factor 1 Gene

Also Known as ADD1; ADD-1; Srebp1; SREBP-1; SREBP-1c

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 78968

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including response to peptide hormone; response to progesterone; and response to retinoic acid. Located in nucleus. Part of protein-containing complex. Biomarker of alcoholic hepatitis; diabetic neuropathy; kidney disease; lipid storage disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in disease of metabolism and type 2 diabetes mellitus. Orthologous to human SREBF1 (sterol regulatory element binding transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Srebf1 Products (2)

mRNA Protein Name
NM_001276707.1 NP_001263636.1 sterol regulatory element-binding protein 1 isoform 1 precursor
NM_001276708.1 NP_001263637.1 sterol regulatory element-binding protein 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
16407292 RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16407292 RGD
enables chromatin binding IDA
IDA: Inferred from direct assay
19371623 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
19158095 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9786926 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to fatty acid IEP
IEP: Inferred from expression pattern
19332540 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
10207099 RGD
involved in cellular response to starvation IDA
IDA: Inferred from direct assay
16407292 RGD
involved in cholesterol metabolic process IMP
IMP: Inferred from mutant phenotype
18071061 RGD
involved in lung development IEP
IEP: Inferred from expression pattern
12896875 RGD
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
10207099 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16407292 RGD
involved in regulation of lipid storage IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
10207099 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in response to fatty acid IEP
IEP: Inferred from expression pattern
16222032 RGD
involved in response to food IEP
IEP: Inferred from expression pattern
19357831 RGD
involved in response to fructose IEP
IEP: Inferred from expression pattern
11934685 RGD
involved in response to glucagon IEP
IEP: Inferred from expression pattern
10207099 RGD
involved in response to lipid IEP
IEP: Inferred from expression pattern
12421847 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
26394137 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
19371623 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
18801905 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
11278421 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
9121491 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17526932 RGD
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
19158095 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sterol regulatory element-binding protein 1

  • adipocyte determination- and differentiation-dependent factor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1856 Proinsulin C-peptide (human) Inhibitor 99.54% Unkown
HY-50670 DGAT-1 inhibitor 2 95.33% Unkown
HY-RS13757 SREBF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-184415 Syk/HDAC6-IN-1 / Unkown
HY-RS17721 Srebf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24186 Srebf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29460 SREBF1 Pig Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Srebf1 NCBI NCBI:6720