Alox15 - arachidonate 15-lipoxygenase Gene

Also Known as 12-LOX; 15-LOX; Alox12; Alox12l

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81639

About Alox15

Primary_assembly 10: 55,060,412-55,068,874 reverse strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 168 orthologues, 6 paralogues and is associated with 22 phenotypes. Biased expression in Spleen (RPKM 287.1), Lung (RPKM 941.1) and 1 other tissue.

Summary

Enables hepoxilin A3 synthase activity; hepoxilin-epoxide hydrolase activity; and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Involved in fatty acid metabolic process and positive regulation of heterotypic cell-cell adhesion. Located in cytosol. Biomarker of brain ischemia; congestive heart failure; and glomerulonephritis. Orthologous to human ALOX15 (arachidonate 15-lipoxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Alox15 Products (1)

mRNA Protein Name
NM_031010.2 NP_112272.2 polyunsaturated fatty acid lipoxygenase ALOX15

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables arachidonate 12(S)-lipoxygenase activity IDA
IDA: Inferred from direct assay
8117750 RGD
enables arachidonate 15-lipoxygenase activity IDA
IDA: Inferred from direct assay
8444196 RGD
enables hepoxilin A3 synthase activity IDA
IDA: Inferred from direct assay
15123652 RGD
enables hepoxilin-epoxide hydrolase activity IDA
IDA: Inferred from direct assay
15123652 RGD
Biological Process GO Annotation Evidence References Source
involved in arachidonate metabolic process IDA
IDA: Inferred from direct assay
8117750 RGD
involved in hepoxilin biosynthetic process IDA
IDA: Inferred from direct assay
15123652 RGD
involved in lipoxygenase pathway IDA
IDA: Inferred from direct assay
8117750 RGD
involved in positive regulation of heterotypic cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
15576842 RGD
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
15123652 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Alox15 Protein Structure

PLAT

PLAT: cl00011 (137 - 204)

Lipoxygenase

Lipoxygenase: cl37981 (294 - 746)

  • 0
  • 200
  • 400
  • 600
  • 756 a.a.
Protein Preferred Names Protein Names

polyunsaturated fatty acid lipoxygenase ALOX15

  • 12/15-LOX

  • 12/15-lipoxygenase

  • arachidonate 12-lipoxygenase, leukocyte-type

  • arachidonate omega-6 lipoxygenase

  • hepoxilin A3 synthase Alox15

  • linoleate 13S-lipoxygenase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-143787 ALOX15-IN-1 Inhibitor 98.01% Unkown
HY-143791 ALOX15-IN-2 Inhibitor 99.88% Unkown
HY-113509B 15(R)-Lipoxin A4 98.3% Unkown
HY-RS00616 ALOX15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00619 ALOX15B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00617 Alox15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00618 Alox15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27130 Alox15b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Alox15 NCBI NCBI:246