ALOX15 - arachidonate 15-lipoxygenase Gene

Also Known as LOG15; 12-LOX; 15-LOX; 15-LOX-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 246

About ALOX15

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,630,919-4,641,678 (from NCBI)

This gene has 6 transcripts (splice variants), 168 orthologues and 5 paralogues. Biased expression in lung (RPKM 5.0), small intestine (RPKM 1.7) and 11 other tissues.

Summary

This gene encodes a member of the Lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and Other molecules. The encoded enzyme and its reaction products have been shown to regulate inflammation and immunity. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]

ALOX15 Products (1)

mRNA Protein Name
NM_001140.5 NP_001131.3 polyunsaturated fatty acid lipoxygenase ALOX15

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables arachidonate 12(S)-lipoxygenase activity IDA
IDA: Inferred from direct assay
1944593 GOA
enables arachidonate 15-lipoxygenase activity IDA
IDA: Inferred from direct assay
1944593 GOA
enables linoleate 13S-lipoxygenase activity IDA
IDA: Inferred from direct assay
8334154 GOA
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: Inferred from direct assay
17052953 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21831839 GOA
Biological Process GO Annotation Evidence References Source
involved in arachidonate metabolic process IDA
IDA: Inferred from direct assay
1944593 GOA
involved in cellular response to calcium ion IDA
IDA: Inferred from direct assay
17052953 GOA
involved in cellular response to interleukin-13 IMP
IMP: Inferred from mutant phenotype
21831839 GOA
involved in linoleic acid metabolic process IDA
IDA: Inferred from direct assay
8334154 GOA
involved in lipid metabolic process IDA
IDA: Inferred from direct assay
23242647 GOA
involved in lipoxygenase pathway IDA
IDA: Inferred from direct assay
1944593 GOA
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
21831839 GOA
involved in positive regulation of cell-substrate adhesion IDA
IDA: Inferred from direct assay
11278875 GOA
involved in regulation of inflammatory response IDA
IDA: Inferred from direct assay
23242647 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
17052953 GOA
located in cytosol IDA
IDA: Inferred from direct assay
17052953 GOA
located in lipid droplet IDA
IDA: Inferred from direct assay
19528634 GOA
located in membrane IDA
IDA: Inferred from direct assay
21831839 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALOX15 Protein Structure

PLAT

PLAT: PLAT/LH2 domain (4 - 104)

Lipoxygenase

Lipoxygenase: Lipoxygenase (157 - 210)

Lipoxygenase

Lipoxygenase: Lipoxygenase (211 - 654)

  • 0
  • 200
  • 400
  • 600
  • 662 a.a.
Protein Preferred Names Protein Names

polyunsaturated fatty acid lipoxygenase ALOX15

  • 12/15-lipoxygenase

  • 15-LOX type 1

  • 15-lipooxygenase-1

  • 15-lipoxygenase type 1

  • arachidonate 12-lipoxygenase, leukocyte-type

  • arachidonate omega-6 lipoxygenase

  • hepoxilin A3 synthase Alox15

  • linoleate 13S-lipoxygenase

ALOX15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ALOX15 P16050 TIMM29 Homo sapiens Q9BSF4
Anti Tag CoIP
28514442
Intra
ALOX15 P16050 TIMM29 Homo sapiens Q9BSF4
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

ALOX15 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81346 15 Lipoxygenase 1/ALOX15 Antibody (YA1091) IHC-P Human
HY-P81346A 15 Lipoxygenase 1/ALOX15 Antibody (YA1091)(PBS only) IHC-P Human
HY-P81564 15 Lipoxygenase 1/ALOX15 Atibody (YA1309) IHC-P, ICC/IF, FC Human

Related Diseases

Diseases Alias
Ichthyosis, Congenital, Autosomal Recessive 3

  • Autosomal Recessive Congenital Ichthyosis 3

  • ARCI3

  • Lamellar Ichthyosis 5

  • Collodion Baby, Self-Healing

  • Ichthyosis, Lamellar, 5, Formerly

  • Li5, Formerly

  • Li5

  • Self-Healing Collodion Baby

  • Ichthyosis, Congenital, Autosomal Recessive, Type 3
Malaria

  • Malaria, Susceptibility To

  • Malaria, Resistance To

  • Malaria, Cerebral

  • Cerebral Malaria

  • Malaria, Severe, Susceptibility To

  • Malaria, Severe, Resistance To

  • Malaria, Cerebral, Susceptibility To

  • Induced Malaria

  • Malaria, Vivax, Protection Against

  • Malaria, Severe

  • Malaria, Cerebral, Reduced Risk Of

  • Malaria, Protection Against

  • Resistance To Malaria Due To G6pd Deficiency

  • Malaria Due To G6pd Deficiency

  • Malarial Encephalitis

  • CM

  • Malaria Cerebral

  • Susceptibility To Malaria

  • Acute Pernicious Fever

  • Aestivo-Autumnal Fever

  • Aestivo Autumnal Malaria

  • Chagres Fever

  • Continued Malaria Fever

  • Estivo-Autumnal Fever

  • Estivo-Autumnal Malaria

  • Estivo-Autumnal Malarial Fever

  • Falciparum Fever

  • Malignant Tertian Fever

  • Malignant Tertian Malaria

  • Pernicious Intermittent Fever

  • Pernicious Malaria

  • Quotidian Malaria

  • Subtertian Fever

  • Subtertian Malaria Fever

  • Subtertian Malignant Tertian Malaria

  • Tropical Malaria

  • Algid Malaria

  • Bilious Haemoglobinuric Fever

  • Black Water Fever

  • Blackwater Fever

  • Malarial Blackwater Fever

  • Severe Malarial Falciparum

  • West African Fever

  • Malarial Haematinuria

  • Haemoglobinuric Fever

  • Haemoglobinuric Malaria

  • Severe Plasmodium Falciparum Malaria

  • Malarial Haemoglobinuria

  • Malarial Haematuria

  • Falciparum Malaria [Malignant Tertian]

  • Malaria Tropica

  • Malarial Shock

  • Chagres Virus Disease

  • Malignant Malaria

  • Mtm - [Malignant Tertian Malaria]

  • Tm -[Malignant Tertian Malaria]

  • Panama Fever

  • St - [Subtertian Malaria]

  • Malarial Quotidian

  • Benign Tertian Malaria

  • Tertian Ague

  • Vivax Fever

  • Plasmodium Vivax Malaria Nos

  • Btm - [Benign Tertian Malaria]

  • Bt - [Benign Tertian Malaria]

  • Vivax Malaria

  • Benign Tertian Vivax Malaria

  • Tertian Malaria

  • Quartan Malaria

  • Quartan Ague

  • Quartan Fever

  • Plasmodium Malariae Malaria Nos

  • Quartan Malarial

  • Malaria By Plasmodium Malariae

  • Malariae Malaria

  • Ovale Tertian Malaria

  • Plasmodium Ovale Fever

  • Malaria Fever By Plasmodium Ovale

  • Ovale Malaria

  • Malaria By Plasmodium Ovale

  • Malarial Ovale

  • Marsh Fever

  • Remittent Congestive Fever

  • Coastal Fever

  • Remittent Gastric Fever

  • Miasmatic Fever

  • Congestive Remittent Fever

  • Intermittent Fever

  • Jungle Fever

  • Paludism

  • Cameroon Fever

  • Ague

  • Corsican Fever

  • Intermittent Bilious Fever

  • Disease Due To Plasmodiidae

  • Malarial Fever

  • Plasmodiosis

  • Remittent Fever

  • Roman Fever

  • Malaria Fever Nos

  • Malaria Nos

  • Paludal Fever

  • Clinically Diagnosed Malaria

  • Clinically Diagnosed Malaria Without Parasitological Confirmation

  • Congestive Fever

  • Malarial Cachexia

  • Marsh Cachexia

  • Paludal Cachexia

  • Recurrent Malaria

  • Remittent Malaria
Cone-Rod Dystrophy 17

  • CORD17
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-143787 ALOX15-IN-1 Inhibitor 98.01% Unkown
HY-143791 ALOX15-IN-2 Inhibitor 99.88% Unkown
HY-113509B 15(R)-Lipoxin A4 98.3% Unkown
HY-RS00616 ALOX15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00619 ALOX15B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00617 Alox15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00618 Alox15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27130 Alox15b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ALOX15 VGNC VGNC:25843
Mus musculus ALOX15 MGD MGI:87997
Rattus norvegicus ALOX15 RGD RGD:70493
Macaca mulatta ALOX15 VGNC VGNC:69796
Canis familiaris ALOX15 VGNC VGNC:37811
Others ALOX15 NCBI