2. Gene
  3. Gnrhr - gonadotropin releasing hormone receptor Gene

Gnrhr - gonadotropin releasing hormone receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as GH1; Lhrhr

Gene ID: 81668 | Gene type: protein coding

About Gnrhr

Primary_assembly 14: 21,856,871-21,874,861 forward strand.mRatBN7.2:CM026987.1

This gene has 1 transcript (splice variant), 241 orthologues, 16 paralogues and is associated with 9 phenotypes. Biased expression in Testes (RPKM 82.5), Adrenal (RPKM 42.5) and 1 other tissue.

Summary

Enables growth hormone-releasing hormone receptor activity. Involved in G protein-coupled receptor signaling pathway; circadian rhythm; and negative regulation of cell population proliferation. Located in plasma membrane. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 7 with or without anosmia. Orthologous to human GNRHR (gonadotropin releasing hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]

Gnrhr Products(1)

mRNA Protein Name
NM_031038.3 NP_112300.2 gonadotropin-releasing hormone receptor

Gnrhr Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (35 - 326)

7tm_GPCRs

7tm_GPCRs: cd14964 (37 - 66)

7tm_GPCRs

7tm_GPCRs: cd14964 (76 - 99)

7tm_GPCRs

7tm_GPCRs: cd14964 (114 - 136)

7tm_GPCRs

7tm_GPCRs: cd14964 (157 - 173)

7tm_GPCRs

7tm_GPCRs: cd14964 (207 - 230)

7tm_GPCRs

7tm_GPCRs: cd14964 (264 - 286)

7tm_GPCRs

7tm_GPCRs: cd14964 (300 - 325)

  • 0
  • 100
  • 200
  • 300
  • 327 a.a.
Protein Preferred Names Protein Names

gonadotropin-releasing hormone receptor

gnRH receptor

gnRH-R

growth hormone

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16168A Degarelix 99.92% Unkown
HY-14369 Elagolix sodium Antagonist 99.94% Unkown
HY-16168B Degarelix acetate hydrate / Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-14789 (R)-Elagolix Antagonist 96.22% Phase 3
Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W041308 DCOIT Agonist 99.74% Unkown
HY-151247 GnRH-R antagonist 1 Antagonist / Unkown
HY-133080 BAY-784 Antagonist / Unkown
HY-14369S Elagolix-13C,d3 sodium Antagonist / Unkown
HY-16168AS Degarelix-d7 Antagonist / Unkown
HY-RS05578 GNRHR Human Pre-designed siRNA Set A / Unkown
HY-RS05579 Gnrhr Mouse Pre-designed siRNA Set A / Unkown
HY-RS05580 Gnrhr Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gnrhr NCBI NCBI:2798
Macaca mulatta Gnrhr NCBI NCBI:711577