Kcnma1 - potassium calcium-activated channel subfamily M alpha 1 Gene

Also Known as Slo; BKCa; cbv1; slo1; Kcnma; maxiK; KCa1.1; KCNMA1b; KCNMA1c; slo-alpha; BKCA alpha; k(VCA)alpha

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 83731

Summary

Enables identical protein binding activity; large conductance calcium-activated Potassium Channel activity; and ligand-gated ion channel activity involved in regulation of presynaptic membrane potential. Involved in several processes, including negative regulation of small intestine smooth muscle contraction; positive regulation of neuron apoptotic process; and response to estrogen. Located in several cellular components, including external side of plasma membrane; neuronal cell body; and presynaptic active zone membrane. Part of protein-containing complex. Is active in glutamatergic synapse. Is integral component of presynaptic active zone membrane. Colocalizes with mitochondrion. Human ortholog(s) of this gene implicated in Alzheimer's disease and idiopathic generalized epilepsy. Orthologous to human KCNMA1 (potassium calcium-activated channel subfamily M alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcnma1 Products (4)

mRNA	Protein	Name
NM_001393699.1	NP_001380628.1	calcium-activated potassium channel subunit alpha-1 isoform 2
NM_001393700.1	NP_001380629.1	calcium-activated potassium channel subunit alpha-1 isoform 3
NM_001393701.1	NP_001380630.1	calcium-activated potassium channel subunit alpha-1 isoform 4
NM_031828.2	NP_114016.2	calcium-activated potassium channel subunit alpha-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium-activated potassium channel activity	IDA IDA: Inferred from direct assay	9403560	RGD
enables calcium-activated potassium channel activity	IMP IMP: Inferred from mutant phenotype	16166559	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	16045448	RGD
enables large conductance calcium-activated potassium channel activity	IDA IDA: Inferred from direct assay	17068255	RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	EXP EXP: Inferred from Experiment	11739569	RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA IDA: Inferred from direct assay	11739569	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16045448	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	15141163	RGD
enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	9403560	RGD
enables voltage-gated potassium channel activity	IMP IMP: Inferred from mutant phenotype	16166559	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in blood vessel diameter maintenance	IDA IDA: Inferred from direct assay	11157674	RGD
involved in negative regulation of small intestine smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	23647678	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	23653329	RGD
involved in response to calcium ion	IDA IDA: Inferred from direct assay	15111404	RGD
involved in response to estrogen	IDA IDA: Inferred from direct assay	16102753	RGD
involved in response to hypoxia	IDA IDA: Inferred from direct assay	15528406	RGD
involved in response to pH	IDA IDA: Inferred from direct assay	12719228	RGD
involved in vasodilation	IMP IMP: Inferred from mutant phenotype	23432816	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in dendrite	IDA IDA: Inferred from direct assay	16045448	RGD
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	16045448	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	11739569	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	11739569	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	16045448	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10384881	RGD
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	11739569	RGD
located in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	11739569	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	17068255	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
calcium-activated potassium channel subunit alpha-1	BK channel calcium-activated potassium channel alpha subunit calcium-activated potassium channel, subfamily M subunit alpha-1 maxi K channel potassium channel, calcium activated large conductance subfamily M alpha, member 1 potassium large conductanc

Kcnma1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Kcnma1	Q62976	Mbp	Rattus norvegicus	P02688	IF	17610306
Intra	Kcnma1	Q62976	Mbp	Rattus norvegicus	P02688	Pull Down	17610306
Intra	Kcnma1	Q62976	Mbp	Rattus norvegicus	P02688	Anti Bait CoIP	17610306

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07164	KCNMA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20560	Kcnma1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27069	Kcnma1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnma1	NCBI	NCBI:3778