STX7 - syntaxin 7 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8417

About STX7

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:132,445,867-132,513,472 (from NCBI)

This gene has 4 transcripts (splice variants), 210 orthologues and 12 paralogues. Ubiquitous expression in lymph node (RPKM 31.8), spleen (RPKM 19.7) and 24 other tissues.

Summary

The protein encoded by this gene is a syntaxin family membrane receptor involved in vesicle transport. The encoded protein binds alpha-SNAP, an important regulator of transport vesicle fusion. Along with syntaxin 13, this protein plays a role in the ordered fusion of endosomes and lysosomes with the phagosome. [provided by RefSeq, May 2016]

STX7 Products (4)

mRNA Protein Name
NM_001326578.2 NP_001313507.1 syntaxin-7 isoform a
NM_001326579.2 NP_001313508.1 syntaxin-7 isoform a
NM_001326580.2 NP_001313509.1 syntaxin-7 isoform b
NM_003569.3 NP_003560.2 syntaxin-7 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SNARE binding IDA
IDA: Inferred from direct assay
24550300 GOA
enables chloride channel inhibitor activity IDA
IDA: Inferred from direct assay
18570918 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11382755 GOA
enables syntaxin binding IPI
IPI: Inferred from physical interaction
10564279 GOA
Biological Process GO Annotation Evidence References Source
involved in organelle assembly IDA
IDA: Inferred from direct assay
21438968 GOA
involved in organelle localization IDA
IDA: Inferred from direct assay
21438968 GOA
involved in positive regulation of T cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
21438968 GOA
involved in positive regulation of receptor localization to synapse IMP
IMP: Inferred from mutant phenotype
21438968 GOA
involved in regulation of protein localization to plasma membrane IDA
IDA: Inferred from direct assay
18570918 GOA
Cellular Component GO Annotation Evidence References Source
located in azurophil granule IDA
IDA: Inferred from direct assay
20170677 GOA
located in early endosome IDA
IDA: Inferred from direct assay
10564279 GOA
located in endocytic vesicle IDA
IDA: Inferred from direct assay
10564279 GOA
located in endosome IDA
IDA: Inferred from direct assay
10564279 GOA
located in immunological synapse IDA
IDA: Inferred from direct assay
21438968 GOA
located in late endosome IDA
IDA: Inferred from direct assay
18980942 GOA
located in lysosome IDA
IDA: Inferred from direct assay
18980942 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
18570918 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
18980942 GOA
located in recycling endosome IDA
IDA: Inferred from direct assay
18570918 GOA
located in tertiary granule IDA
IDA: Inferred from direct assay
20170677 GOA
located in vesicle IDA
IDA: Inferred from direct assay
18570918 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STX7 Protein Structure

Syntaxin_2

Syntaxin_2: Syntaxin-like protein (18 - 118)

SNARE

SNARE: SNARE domain (170 - 232)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

syntaxin-7

STX7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STX7 O15400 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra
STX7 O15400 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
STX7 O15400 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
STX7 O15400 LSMEM2 Homo sapiens Q8N112
Validated Y2H
32296183
Intra
STX7 O15400 LSMEM2 Homo sapiens Q8N112
Y2H Array
32296183
Intra
STX7 O15400 LSMEM2 Homo sapiens Q8N112
Y2H Prey Pooling
32296183
Intra
STX7 O15400 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra
STX7 O15400 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra
STX7 O15400 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
32296183
Intra
STX7 O15400 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra
STX7 O15400 CISD2 Homo sapiens Q8N5K1
Validated Y2H
32296183
Intra
STX7 O15400 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra
STX7 O15400 HSD17B11 Homo sapiens Q8NBQ5
Y2H Array
32296183
Intra
STX7 O15400 HSD17B11 Homo sapiens Q8NBQ5
Y2H Prey Pooling
32296183
Intra
STX7 O15400 HSD17B11 Homo sapiens Q8NBQ5
Validated Y2H
32296183
Intra
STX7 O15400 VPS18 Homo sapiens Q9P253
Anti Tag CoIP
11382755
Intra
STX7 O15400 VPS18 Homo sapiens Q9P253
Anti Bait CoIP
11382755
Intra
STX7 O15400 ELOVL5 Homo sapiens Q9NYP7
Y2H Prey Pooling
32296183
Intra
STX7 O15400 ELOVL5 Homo sapiens Q9NYP7
Y2H Array
32296183
Intra
STX7 O15400 ELOVL5 Homo sapiens Q9NYP7
Validated Y2H
32296183
Intra
STX7 O15400 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
Intra
STX7 O15400 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
STX7 O15400 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
STX7 O15400 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
Intra
STX7 O15400 TMEM80 Homo sapiens Q96HE8
Validated Y2H
32296183
Intra
STX7 O15400 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
Intra
STX7 O15400 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra
STX7 O15400 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra
STX7 O15400 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra
STX7 O15400 STX2 Homo sapiens P32856-2
Y2H Prey Pooling
32296183
Intra
STX7 O15400 STX2 Homo sapiens P32856-2
Validated Y2H
32296183
Intra
STX7 O15400 STX2 Homo sapiens P32856-2
Y2H Array
32296183
Intra
STX7 O15400 TMPRSS2 Homo sapiens O15393-2
Y2H Prey Pooling
32296183
Intra
STX7 O15400 TMPRSS2 Homo sapiens O15393-2
Y2H Array
32296183
Intra
STX7 O15400 RIC3 Homo sapiens Q7Z5B4-5
Y2H Prey Pooling
32296183
Intra
STX7 O15400 RIC3 Homo sapiens Q7Z5B4-5
Validated Y2H
32296183
Intra
STX7 O15400 RIC3 Homo sapiens Q7Z5B4-5
Y2H Array
32296183
Intra
STX7 O15400 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
STX7 O15400 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
STX7 O15400 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
STX7 O15400 REEP1 Homo sapiens Q9H902
Y2H Prey Pooling
32296183
Intra
STX7 O15400 REEP1 Homo sapiens Q9H902
Validated Y2H
32296183
Intra
STX7 O15400 REEP1 Homo sapiens Q9H902
Y2H Array
32296183
Intra
STX7 O15400 TMEM267 Homo sapiens Q0VDI3
Y2H Prey Pooling
32296183
Intra
STX7 O15400 TMEM267 Homo sapiens Q0VDI3
Validated Y2H
32296183
Intra
STX7 O15400 TMEM267 Homo sapiens Q0VDI3
Y2H Array
32296183
Intra
STX7 O15400 MTUS1 Homo sapiens Q9ULD2-3
Validated Y2H
32296183
Intra
STX7 O15400 MTUS1 Homo sapiens Q9ULD2-3
Y2H Array
32296183
Intra
STX7 O15400 MTUS1 Homo sapiens Q9ULD2-3
Y2H Prey Pooling
32296183
Intra
STX7 O15400 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
STX7 O15400 HSD17B13 Homo sapiens Q7Z5P4
Validated Y2H
32296183
Intra
STX7 O15400 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
STX7 O15400 SLC10A6 Homo sapiens Q3KNW5
Validated Y2H
32296183
Intra
STX7 O15400 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
STX7 O15400 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
STX7 O15400 TMEM241 Homo sapiens Q24JQ0
Y2H Array
32296183
Intra
STX7 O15400 TMEM241 Homo sapiens Q24JQ0
Y2H Prey Pooling
32296183
Intra
STX7 O15400 TMEM241 Homo sapiens Q24JQ0
Validated Y2H
32296183
Intra
STX7 O15400 FAM174A Homo sapiens Q8TBP5
Y2H Array
32296183
Intra
STX7 O15400 FAM174A Homo sapiens Q8TBP5
Y2H Prey Pooling
32296183
Intra
STX7 O15400 FAM174A Homo sapiens Q8TBP5
Validated Y2H
32296183
Intra
STX7 O15400 FAM210B Homo sapiens Q96KR6
Y2H Array
32296183
Intra
STX7 O15400 FAM210B Homo sapiens Q96KR6
Y2H Prey Pooling
32296183
Intra
STX7 O15400 FAM210B Homo sapiens Q96KR6
Validated Y2H
32296183
Intra
STX7 O15400 GJC3 Homo sapiens Q8NFK1
Y2H Prey Pooling
32296183
Intra
STX7 O15400 GJC3 Homo sapiens Q8NFK1
Validated Y2H
32296183
Intra
STX7 O15400 GJC3 Homo sapiens Q8NFK1
Y2H Array
32296183
Intra
STX7 O15400 CERS4 Homo sapiens Q9HA82
Validated Y2H
32296183
Intra
STX7 O15400 CERS4 Homo sapiens Q9HA82
Y2H Prey Pooling
32296183
Intra
STX7 O15400 CERS4 Homo sapiens Q9HA82
Y2H Array
32296183
Intra
STX7 O15400 LIME1 Homo sapiens Q9H400
Y2H Prey Pooling
32296183
Intra
STX7 O15400 LIME1 Homo sapiens Q9H400
Validated Y2H
32296183
Intra
STX7 O15400 LIME1 Homo sapiens Q9H400
Y2H Array
32296183
Intra
STX7 O15400 ZFYVE27 Homo sapiens Q5T4F4
Validated Y2H
32296183
Intra
STX7 O15400 ZFYVE27 Homo sapiens Q5T4F4
Y2H Prey Pooling
32296183
Intra
STX7 O15400 ZFYVE27 Homo sapiens Q5T4F4
Y2H Array
32296183
Intra
STX7 O15400 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
STX7 O15400 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
STX7 O15400 EBP Homo sapiens Q15125
Validated Y2H
32296183
Intra
STX7 O15400 FKBP7 Homo sapiens Q9Y680
Validated Y2H
32296183
Intra
STX7 O15400 FKBP7 Homo sapiens Q9Y680
Y2H Array
32296183
Intra
STX7 O15400 FKBP7 Homo sapiens Q9Y680
Y2H Prey Pooling
32296183
Intra
STX7 O15400 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
Intra
STX7 O15400 SAR1A Homo sapiens Q9NR31
Validated Y2H
32296183
Intra
STX7 O15400 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
Intra
STX7 O15400 SLC10A1 Homo sapiens Q14973
Validated Y2H
32296183
Intra
STX7 O15400 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
Intra
STX7 O15400 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
Intra
STX7 O15400 YKT6 Homo sapiens O15498
Anti Tag CoIP
33961781
Intra
STX7 O15400 MRM1 Homo sapiens Q6IN84
Validated Y2H
32296183
Intra
STX7 O15400 MRM1 Homo sapiens Q6IN84
Y2H Prey Pooling
32296183
Intra
STX7 O15400 MRM1 Homo sapiens Q6IN84
Y2H Array
32296183
Intra
STX7 O15400 TMEM205 Homo sapiens Q6UW68
Validated Y2H
32296183
Intra
STX7 O15400 TMEM205 Homo sapiens Q6UW68
Y2H Array
32296183
Intra
STX7 O15400 TMEM205 Homo sapiens Q6UW68
Y2H Prey Pooling
32296183
Intra
STX7 O15400 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
STX7 O15400 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
STX7 O15400 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
STX7 O15400 TM4SF19 Homo sapiens Q96DZ7
Validated Y2H
32296183
Intra
STX7 O15400 TM4SF19 Homo sapiens Q96DZ7
Y2H Prey Pooling
32296183
Intra
STX7 O15400 TM4SF19 Homo sapiens Q96DZ7
Y2H Array
32296183
Intra
STX7 O15400 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
STX7 O15400 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
STX7 O15400 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
STX7 O15400 ANKS6 Homo sapiens Q68DC2
Y2H Array
32296183
Intra
STX7 O15400 ANKS6 Homo sapiens Q68DC2
Y2H Prey Pooling
32296183
Intra
STX7 O15400 ANKS6 Homo sapiens Q68DC2
Validated Y2H
32296183
Intra
STX7 O15400 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra
STX7 O15400 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra
STX7 O15400 STX1A Homo sapiens Q16623
Validated Y2H
32296183
Intra
STX7 O15400 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra
STX7 O15400 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra
STX7 O15400 VAMP8 Homo sapiens Q9BV40
Anti Tag CoIP
33961781
Intra
STX7 O15400 STX4 Homo sapiens Q12846
Y2H Prey Pooling
25416956
Intra
STX7 O15400 STX4 Homo sapiens Q12846
Y2H Prey Pooling
32296183
Intra
STX7 O15400 STX4 Homo sapiens Q12846
Validated Y2H
32296183
Intra
STX7 O15400 STX4 Homo sapiens Q12846
Y2H Array
25416956
Intra
STX7 O15400 STX4 Homo sapiens Q12846
Anti Tag CoIP
33961781
Intra
STX7 O15400 STX4 Homo sapiens Q12846
Y2H Array
32296183
Intra
STX7 O15400 CYBRD1 Homo sapiens Q53TN4
Y2H Array
32296183
Intra
STX7 O15400 CYBRD1 Homo sapiens Q53TN4
Y2H Prey Pooling
32296183
Intra
STX7 O15400 CYBRD1 Homo sapiens Q53TN4
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant STX7 Proteins

Cat. No. Product Name Accession Purity
HY-P71024 STX7 Protein, Human (HEK293, His) O15400 (S2-L238) ≥ 95%, as determined by reducing SDS-PAGE.

STX7 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811323 Syntaxin-7 Antibody WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Neuronal Migration Disorders

  • Abnormality Of Neuronal Migration

  • Malformations Of Cortical Development, Group Ii

  • Neuronal Dysmigration Syndromes
Hemophagocytic Lymphohistiocytosis, Familial, 4

  • Familial Hemophagocytic Lymphohistiocytosis 4

  • FHL4

  • Hplh4

  • Hlh4

  • Lymphohistiocytosis, Hemophagocytic, Familial, Type 4
Hermansky-Pudlak Syndrome

  • Hps

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

  • Hermanski-Pudlak Syndrome

  • Hermansky Pudlak Syndrome

  • Platelet Storage Pool Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-183079 ENDO12 Inhibitor / Unkown
HY-RS13987 STX7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19164 Stx7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25653 Stx7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris STX7 VGNC VGNC:46958
Macaca mulatta STX7 VGNC VGNC:78047
Bos taurus STX7 VGNC VGNC:35443
Rattus norvegicus STX7 RGD RGD:619747
Mus musculus STX7 MGD MGI:1858210
Felis catus STX7 VGNC VGNC:102526
Others STX7 NCBI