ACBD6 - acyl-CoA binding domain containing 6 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84320

About ACBD6

Cytogenetic location: 1q25.2-q25.3 Genomic coordinates (GRCh38): 1:180,269,653-180,502,577 (from NCBI)

This gene has 8 transcripts (splice variants), 212 orthologues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 4.9), placenta (RPKM 3.6) and 25 other tissues.

Summary

Predicted to enable fatty-acyl-CoA binding activity and lipid binding activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

ACBD6 Products (1)

mRNA	Protein	Name
NM_032360.4	NP_115736.1	acyl-CoA-binding domain-containing protein 6

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables fatty-acyl-CoA binding	IMP IMP: Inferred from mutant phenotype	37951597	GOA
enables lipid binding	IMP IMP: Inferred from mutant phenotype	37951597	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26621918	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	37951597	GOA
located in nucleus	IDA IDA: Inferred from direct assay	37951597	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACBD6 Protein Structure

ACBP

Ank_2

0
100
200
282 a.a.

Protein Preferred Names	Protein Names
acyl-CoA-binding domain-containing protein 6	acyl-Coenzyme A binding domain containing 6

ACBD6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ACBD6	Q9BR61	NMT2	Homo sapiens	O60551	Anti Tag CoIP	26621918
Intra	ACBD6	Q9BR61	NMT2	Homo sapiens	O60551	Gal4 VP16 Complement	26621918
Intra	ACBD6	Q9BR61	NMT2	Homo sapiens	O60551	Anti Tag CoIP	33961781
Intra	ACBD6	Q9BR61	NMT2	Homo sapiens	O60551	Pull Down	26621918
Intra	ACBD6	Q9BR61	NMT1	Homo sapiens	P30419	Anti Tag CoIP	33961781
Intra	ACBD6	Q9BR61	NMT1	Homo sapiens	P30419	Pull Down	26621918
Intra	ACBD6	Q9BR61	NMT1	Homo sapiens	P30419	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ACBD6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76708	ACBD6 Protein, Human (sf9, His)	Q9BR61 (M1-A282)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Pituitary Hormone Deficiency, Combined, 4	Short Stature-Pituitary And Cerebellar Defects-Small Sella Turcica Syndrome CPHD4 Pituitary Hormone Deficiency, Combined, With Or Without Cerebellar Defects Short Stature, Pituitary And Cerebellar Defects, And Small Sella Turcica Pituitary Hormone Deficiency, Combined 4 Pituitary Hormone Deficiency, Combined With Or Without Cerebellar Defects Short Stature, Pituitary And Cerebellar Defects And Small Sella Turcica Pituitary Hormone Deficiency Combined With Or Without Cerebellar Defects Short Stature Pituitary And Cerebellar Defects And Small Sella Turcica Hormone Deficiency, Pituitary, Combined, Type 4

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00144	ACBD6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22370	Acbd6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28893	Acbd6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ACBD6	VGNC	VGNC:59503
Macaca mulatta	ACBD6	VGNC	VGNC:69510
Canis familiaris	ACBD6	VGNC	VGNC:49787
Bos taurus	ACBD6	VGNC	VGNC:97235
Mus musculus	ACBD6	MGD	MGI:1919732
Rattus norvegicus	ACBD6	RGD	RGD:1305030
Others	ACBD6	NCBI