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NMT1 - N-myristoyltransferase 1 Gene

Also Known as NMT; HsNMT1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4836

About NMT1

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:45,061,317-45,109,016 (from NCBI)

This gene has 19 transcripts (splice variants), 281 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 21.5), thyroid (RPKM 17.0) and 25 other tissues.

Summary

Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and Viral Proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008]

NMT1 Products (1)

mRNA	Protein	Name
NM_021079.5	NP_066565.1	glycylpeptide N-tetradecanoyltransferase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables glycylpeptide N-tetradecanoyltransferase activity	IDA IDA: Inferred from direct assay	25255805	GOA
enables myristoyltransferase activity	IDA IDA: Inferred from direct assay	22865860	GOA
enables peptidyl-lysine N6-myristoyltransferase activity	IDA IDA: Inferred from direct assay	32103017	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26621918	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in N-terminal peptidyl-glycine N-myristoylation	IDA IDA: Inferred from direct assay	25255805	GOA
involved in cellular ketone metabolic process	IDA IDA: Inferred from direct assay	22865860	GOA
involved in protein localization to membrane	IDA IDA: Inferred from direct assay	34999170	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9353336	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	9506952	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NMT1 Protein Structure

NMT

NMT_C

0
100
200
300
400
496 a.a.

Protein Preferred Names	Protein Names
glycylpeptide N-tetradecanoyltransferase 1	alternative, short form NMT-S

NMT1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NMT1	P30419	ACBD6	Homo sapiens	Q9BR61	Validated Y2H	32296183
Intra	NMT1	P30419	ACBD6	Homo sapiens	Q9BR61	Gal4 VP16 Complement	26621918
Intra	NMT1	P30419	ACBD6	Homo sapiens	Q9BR61	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Gallbladder Cancer	Gallbladder Carcinoma Gallbladder Neoplasm Malignant Neoplasm Of Gallbladder Malignant Tumour Of Gallbladder Gallbladder Ca Localized Malignant Gallbladder Neoplasm Malignant Tumor Of The Gallbladder Tumor Of The Gallbladder Cancer Of The Gallbladder Carcinoma Gallbladder Carcinoma Of Gallbladder Gallbladder Neoplasms Malignant Neoplasm Of Gallbladder Localized Cancer Of Gallbladder Primary Malignant Neoplasm Of Gallbladder
Partial Fetal Alcohol Syndrome
Sleeping Sickness	African Trypanosomiasis African Sleeping Sickness Trypanosomiasis, Human East-African Trypanosomiasis, East African Trypanosomiasis African Trypanosomiasis, African Human African Trypanosomiasis
Patent Foramen Ovale	Atrial Septal Defect Within Oval Fossa Foramen Ovale Patent Ostium Secundum Atrial Septal Defect Atrial Septal Defect, Ostium Secundum Type Foramen Ovale, Patent Defect, Patent Or Persistent, Ostium Secundum Ostium Secundum Type Atrial Septal Defect Persistent Ostium Secundum Asd Ostium Secundum Type Ostium Secundum Asd Osasd Asd, Ostium Secundum Type Pfo - [Patent Foramen Ovale] Open Foramen Ovale Open Oval Foramen Persistent Foramen Ovale Secundum Atrial Septal Defect
Atrial Heart Septal Defect	Atrial Septal Defect Atrial Septal Defects Atrioseptal Defect Auricular Septal Defect Congenital Atrial Septal Defect Interatrial Septal Defect Interauricular Septal Defect Heart Septal Defects, Atrial Septal Defect, Atrial
Mitochondrial Complex Iv Deficiency, Nuclear Type 1	Cytochrome C Oxidase Deficiency Mitochondrial Complex Iv Deficiency Cox Deficiency Cytochrome-C Oxidase Deficiency Disease MC1DN4 Cytochrome-C Oxidase Deficiency MC4DN1 Mitochondrial Complex I Deficiency, Nuclear Type 4 Complex 4 Mitochondrial Respiratory Chain Deficiency Complex Iv Deficiency Mitochondrial Complex 1 Deficiency, Nuclear Type 4 Nuclear Type Mitochondrial Complex I Deficiency 4 Deficiency Of Mitochondrial Respiratory Chain Complex4 MT-C4D Complex Iv Mitochondrial Respiratory Chain Deficiency Lethal Neonatal Cardiomyopathy Hypertrophic Due To Cytochrome C Oxidase Deficiency Mitochondrial Complex Iv Deficiency, Nuclear, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112258	IMP-1088	Inhibitor	98.84%	Unkown
HY-147308	Zelenirstat	Inhibitor	99.76%	Unkown
HY-P6028A	GSNKSKPK-NH2 TFA	Substrate	99.91%	Unkown
HY-P6028	GSNKSKPK-NH2	Substrate	98.00%	Unkown
HY-RS09389	NMT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18960	Nmt1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25450	Nmt1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NMT1	VGNC	VGNC:68507
Canis familiaris	NMT1	VGNC	VGNC:43866
Rattus norvegicus	NMT1	RGD	RGD:628642
Macaca mulatta	NMT1	VGNC	VGNC:75360
Bos taurus	NMT1	VGNC	VGNC:32137
Mus musculus	NMT1	MGD	MGI:102579
Others	NMT1	NCBI