TNFSF9 - TNF superfamily member 9 Gene

Homo sapiens

Also known as CD137L; TNLG5A; 4-1BB-L

Gene ID: 8744 | Gene type: protein coding

About TNFSF9

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:6,531,026-6,535,924 (from NCBI)

This gene has 1 transcript (splice variant) and 75 orthologues. Broad expression in colon (RPKM 1.1), bone marrow (RPKM 1.0) and 18 other tissues.

Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]

TNFSF9 Products(1)

mRNA	Protein	Name
NM_003811.4	NP_003802.1	tumor necrosis factor ligand superfamily member 9

TNFSF9 Protein Structure

TNF

0
100
200
254 a.a.

Protein Preferred Names

Protein Names

tumor necrosis factor ligand superfamily member 9

4-1BB ligand

Recombinant TNFSF9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7113	4-1BBL/TNFSF9 Protein, Human	P41273 (R71-E254)	≥95%
HY-P78069	4-1BBL/TNFSF9 Protein, Human (Biotinylated, HEK293, Fc)	P41273 (R71-E254)	≥95%
HY-P78933	4-1BBL/TNFSF9 Protein, Human (Biotinylated, HEK293, Fc-Avi)	P41273 (A50-E254)	≥95%
HY-P700012AF	Animal-Free 4-1BBL/TNFSF9 Protein, Human (His)	P41273 (M70-EE254)	≥95%
HY-P700435	4-1BBL/TNFSF9 Protein, Human (HEK293, hFc-Myc)	P41273 (R71-E254)	≥95%
HY-P700518	4-1BBL/TNFSF9 Protein, Human (His)	P41273 (P52-E254)	≥95%

Related Diseases

Diseases

Alias

Immunodeficiency 16

Combined Immunodeficiency Due To Ox40 Deficiency	IMD16
Ox40 Deficiency	Combined Immunodeficiency With Childhood-Onset Kaposi Sarcoma
Combined Immunodeficiency With Impaired Immunity To Hhv-8	Combined Immunodeficiency With Impaired Immunity To Human Herpes Virus 8
Immunodeficiency, Type 16

Mouth Disease

Mouth Diseases

Mouth Disorders

Lymphoproliferative Syndrome 2

Cd27 Deficiency	LPFS2
Combined Immunodeficiency Due To Cd27 Deficiency	Autosomal Recessive Lymphoproliferative Disease Due To Cd27 Deficiency

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14830	TNFSF9 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TNFSF9	VGNC	VGNC:36178
Mus musculus	TNFSF9	MGD	MGI:1101058
Canis familiaris	TNFSF9	VGNC	VGNC:47674
Felis catus	TNFSF9	VGNC	VGNC:80744
Macaca mulatta	TNFSF9	VGNC	VGNC:78599
Rattus norvegicus	TNFSF9	RGD	RGD:727974
Macaca fascicularis	TNFSF9	NCBI
Others	TNFSF9	NCBI

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