ACVR1 - activin A receptor type 1 Gene

Also Known as FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 90

About ACVR1

Cytogenetic location: 2q24.1 Genomic coordinates (GRCh38): 2:157,736,446-157,876,330 (from NCBI)

This gene has 26 transcripts (splice variants), 174 orthologues, 11 paralogues and is associated with 77 phenotypes. Ubiquitous expression in thyroid (RPKM 15.1), gall bladder (RPKM 9.4) and 23 other tissues.

Summary

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes Activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]

ACVR1 Products (7)

mRNA	Protein	Name
NM_001347667.2	NP_001334596.1	activin receptor type-1 precursor
NM_001347664.1	NP_001334593.1	activin receptor type-1 precursor
NM_001111067.4	NP_001104537.1	activin receptor type-1 precursor
NM_001105.5	NP_001096.1	activin receptor type-1 precursor
NM_001347663.1	NP_001334592.1	activin receptor type-1 precursor
NM_001347666.1	NP_001334595.1	activin receptor type-1 precursor
NM_001347665.1	NP_001334594.1	activin receptor type-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	12065756	GOA
enables BMP receptor activity	IDA IDA: Inferred from direct assay	12065756	GOA
enables SMAD binding	IDA IDA: Inferred from direct assay	12065756	GOA
enables activin binding	IDA IDA: Inferred from direct assay	8242742	GOA
contributes to activin receptor activity, type I	IDA IDA: Inferred from direct assay	8242742	GOA
enables cadherin binding	IPI IPI: Inferred from physical interaction	26598555	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8242742	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	18436533	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	19736306	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12065756	GOA
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	26598555	GOA
enables transforming growth factor beta binding	IDA IDA: Inferred from direct assay	8242742	GOA
enables transmembrane receptor protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	19506109	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in BMP signaling pathway	IDA IDA: Inferred from direct assay	12065756	GOA
involved in activin receptor signaling pathway	IDA IDA: Inferred from direct assay	19506109	GOA
involved in activin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18326817	GOA
involved in atrial septum primum morphogenesis	IMP IMP: Inferred from mutant phenotype	19506109	GOA
involved in cardiac muscle cell fate commitment	IMP IMP: Inferred from mutant phenotype	19506109	GOA
involved in cellular response to BMP stimulus	IMP IMP: Inferred from mutant phenotype	18326817	GOA
involved in embryonic heart tube morphogenesis	IMP IMP: Inferred from mutant phenotype	19506109	GOA
involved in endocardial cushion cell fate commitment	IMP IMP: Inferred from mutant phenotype	19506109	GOA
involved in mitral valve morphogenesis	IMP IMP: Inferred from mutant phenotype	19506109	GOA
involved in negative regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	9884026	GOA
involved in negative regulation of activin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9884026	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	9884026	GOA
involved in negative regulation of signal transduction	IMP IMP: Inferred from mutant phenotype	9884026	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8242742	GOA
involved in positive regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	19506109	GOA
involved in positive regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	18436533	GOA
involved in positive regulation of cell migration	IGI IGI: Inferred from genetic interaction	19736306	GOA
involved in positive regulation of determination of dorsal identity	IDA IDA: Inferred from direct assay	19506109	GOA
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	18436533	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	26598555	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19506109	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18326817	GOA
involved in regulation of ossification	IMP IMP: Inferred from mutant phenotype	16642017	GOA
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	8242742	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of activin receptor complex	IDA IDA: Inferred from direct assay	8242742	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	8242742	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACVR1 Protein Structure

Activin_recp

TGF_beta_GS

Pkinase

0
100
200
300
400
509 a.a.

Protein Preferred Names	Protein Names
activin receptor type-1	TGF-B superfamily receptor type I activin A receptor, type I activin A receptor, type II-like kinase 2 activin receptor type I activin receptor-like kinase 2 hydroxyalkyl-protein kinase serine/threonine-protein kinase receptor R1

Recombinant ACVR1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7482	Activin RIA Protein, Human (HEK293, His)	Q04771 (M21-V124)	≥ 80%, as determined by reducing SDS-PAGE.
HY-P72812	Activin RIA Protein, Human (HEK293, His-Fc)	Q04771 (M21-V124)	≥ 95%, as determined by reducing SDS-PAGE.

ACVR1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82249	Activin Receptor Type IA Antibody (YA1994)	WB, IP	Human, Mouse
HY-P82249A	Activin Receptor Type IA Antibody (YA1994)(PBS only)	WB, IP	Human, Mouse
HY-P83198	Activin Receptor Type I Antibody (YA2943)	WB, IP	Human, Mouse, Rat
HY-P84482	ACVR1 Antibody (YA4179)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P84482A	ACVR1 Antibody (YA4179)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Epicanthus
Brachydactyly, Type E2	Brachydactyly Type E2 BDE2 Brachydactyly E2
Proximal Symphalangism	Cushing'S Symphalangism Symphalangism, Proximal Hereditary Absence Of Proximal Interphalangeal Joints Strasburger-Hawkins-Eldridge Syndrome Strasburger-Hawkins-Eldridge-Hargrave-Mckusick Syndrome Symphalangism, Proximal, 1a Symphalangism, Proximal, 1b Vessel'S Syndrome Symphalangism, Cushing Type
Diffuse Midline Glioma, H3 K27m-Mutant	Diffuse Intrinsic Pontine Glioma Dipg Infiltrative Brainstem Glioma
Hereditary Hemorrhagic Telangiectasia	Rendu-Osler-Weber Disease Hht Osler-Weber-Rendu Disease Telangiectasia, Hereditary Hemorrhagic Osler Hemorrhagic Telangiectasia Syndrome Orw Disease Osler Weber Rendu Syndrome Osler-Rendu-Weber Disease Osler-Weber-Rendu Syndrome Rendu-Osler Disease Telangiectasia Hereditary Hemorrhagic Telangiectasia Hemorrhagic, Hereditary Hht - [Hereditary Haemorrhagic Telangiectasia] Osler Haemorrhagic Telangiectasia Syndrome
Hyperostosis	Hypertrophy Of Bone Bone Hypertrophy Bone Thickening Periosteum Thickening
Persistent Mullerian Duct Syndrome	Persistent Müllerian Duct Syndrome Pmds Persistent Oviduct Syndrome Persistent Muellerian Duct Syndrome Female Genital Ducts In Otherwise Normal Male Hernia Uteri Inguinale Persistent Mullerian Duct Syndrome, Types 1 And 2 Persistent Mullerian Derivatives
Brain Stem Cancer	Brain Stem Neoplasms Malignant Neoplasm Of Brain Stem Malignant Neoplasm Of Brainstem Neoplasm Of Adult Brain Stem Neoplasm Of Brain Stem Primary Brain Stem Neoplasm Primary Brain Stem Tumor Brain Stem Neoplasm Brain Stem--Cancer Brain Stem Neoplasms, Primary
Craniometaphyseal Dysplasia, Autosomal Dominant	Craniometaphyseal Dysplasia CMDD Cmdj Cmd Autosomal Dominant Craniometaphyseal Dysplasia Craniometaphyseal Dysplasia, Jackson Type Craniometaphyseal Dysplasia Jackson Type Autosomal Recessive Craniometaphyseal Dysplasia Cmdr Dysplasia, Craniometaphyseal, Autosomal Dominant Craniometaphyseal Dysplasia, Autosomal Recessive Type
Fibrodysplasia Ossificans Progressiva	Myositis Ossificans Progressiva Progressive Myositis Ossificans FOP Progressive Ossifying Myositis Myositis Ossificans Stone Man Syndrome Man Of Stone Myositis Ossificans Progressive Diffuse Progressive Ossifying Polymyositis Fibrodysplasia Ossificans Congenita Myositis Ossificans Progressiva, Site Unspecified Münchmeyer Disease Fop - [Fibrodysplasia Ossificans Progressiva] Progressive Myositis Ossificans Calcification
Diffuse Idiopathic Skeletal Hyperostosis	Hyperostosis, Diffuse Idiopathic Skeletal Ankylosing Vertebral Hyperostosis Dish Disseminated Idiopathic Skeletal Hyperostosis Forestier Disease Forestier'S Disease Hyperostosis Diffuse Idiopathic Skeletal
Leber Congenital Amaurosis 17	LCA17 Leber Congenital Amaurosis, Type 17
Microphthalmia, Syndromic 6	MCOPS6 Microphthalmia And Pituitary Anomalies Microphthalmia With Brain And Digit Anomalies Microphthalmia With Brain And Digit Developmental Anomalies Syndromic Microphthalmia Type 6 Syndromic Microphthalmia 6 Anophthalmia Clinical With Micrognathia Malformed Ears Digital Anomalies And Abnormal External Genitalia Bakrania-Ragge Syndrome Orofacial Cleft 11 Anophthalmia, Clinical, With Micrognathia, Malformed Ears, Digital Anomalies, And Abnormal External Genitalia Microphthalmia Syndromic 6 Microphthalmia, Syndromic, 6 Clinical Anophthalmia With Micrognathia, Malformed Ears, Digital Anomalies And Abnormal External Genitalia Microphthalmia Syndromic, Type 6
Childhood Brain Stem Glioma	Pediatric Glioma Of The Brainstem
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Atrioventricular Septal Defect	AVSD Atrioventricular Canal Defect Avcd Endocardial Cushion Defect Ecd Avc Defect Atrioventricular Septal Defect, Susceptibility To, 1 Atrioventricular Septal Defect 1 Endocardial Cushion Defects Septal Defect, Atrioventricular Atrioventricular Defect With Atrial Shunting Only Incomplete Atrioventricular Septal Defect With Isolated Atrial Component Incomplete Atrioventricular Canal Defect With Isolated Atrial Component Primum Atrial Septal Defect Partial Atrioventricular Canal Defect With Isolated Atrial Component Partial Atrioventricular Septal Defect, Ostium Primum Type Ostium Primum Atrial Septal Defect Partial Atrioventricular Canal Defect Partial Atrioventricular Septal Defect Atrial Septum Primum Defect Atrioventricular Canal Defect With Isolated Ventricular Component Atrioventricular Canal Defect With Isolated Ventricular Communication Atrioventricular Septal Defect With Isolated Ventricular Component Atrioventricular Septal Defect With Atrial Shunting And Restrictive Ventricular Shunting Intermediate Atrioventricular Canal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valve Transitional Atrioventricular Septal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valves Atrioventricular Canal Defect Associated With A Restrictive Ventricular Septal Defect Intermediate Atrioventricular Canal Defect Intermediate Atrioventricular Septal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valvar Orifices Intermediate Atrioventricular Septal Defect Transitional Atrioventricular Canal Defect Transitional Atrioventricular Septal Defect Complete Atrioventricular Canal With Atrial And Ventricular Components Complete Atrioventricular Canal Defect Complete Atrioventricular Septal Defect
Pseudohypoparathyroidism, Type Ia	Albright'S Hereditary Osteodystrophy Albright Hereditary Osteodystrophy Pseudohypoparathyroidism Type 1a PHP1A Albright Hereditary Osteodystrophy With Multiple Hormone Resistance Pseudohypoparathyroidism Ia AHO Pseudohypoparathyroidism With Albright Hereditary Osteodystrophy Pseudo-Pseudohypoparathyroidism Pseudohypoparathyroidism Type I A Php Ia Pseudopseudohypoparathyroidism Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance Pphp Pseudopseudo-Hypoparathyroidism Aho-Php Syndrome Ia Albright Hereditary Osteodystrophy-Php Syndrome Ia Pseudohypoparathyroidism 1a Pseudohypoparathyroidism
Aortic Valve Disease 1	Aortic Valve Disease Bicuspid Aortic Valve Aortic Valve Disorder AOVD1 Bav Bicuspid Aortic Valve Disease Familial Bicuspid Aortic Valve Aortic Valve Calcification Aovd Aortic Valve, Bicuspid Aortic Valve, Calcification Of Aortic Stenosis, Calcific Familial Bav Calcific Aortic Stenosis Calcification Of Aortic Valve Abnormality Of The Aortic Valve Aortic Valve Disease, Type 1 Aortic Valve Disease 2 Bicommissural Aortic Valve
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Heel Spur	Calcaneal Spur
Brain Stem Glioma	Brainstem Neuroglial Tumor Brainstem Glioma Glioma Of Brainstem
Chronic Pulmonary Heart Disease
Juvenile Polyposis/Hereditary Hemorrhagic Telangiectasia Syndrome	Juvenile Polyposis-Hereditary Hemorrhagic Telangiectasia Syndrome JPHT Jp/Hht Syndrome Juvenile Polyposis With Hereditary Hemorrhagic Telangiectasia Jps/Hht Telangiectasia, Hereditary Hemorrhagic, With Juvenile Polyposis Coli Polyposis, Generalized Juvenile, With Pulmonary Arteriovenous Malformation Jp-Hht JP/HHT Polyposis, Juvenile/Hereditary Hemorrhagic Telangiectasia Syndrome
Camurati-Engelmann Disease	Progressive Diaphyseal Dysplasia Ced Engelmann Disease Diaphyseal Dysplasia 1, Progressive Pdd Diaphyseal Dysplasia Dpd1 Camurati-Engelmann Syndrome CAEND Engelman'S Disease Diaphyseal Hyperostosis Diaphyseal Osteosclerosis
Ankylosis
Contractures, Pterygia, And Spondylocarpotarsal Fusion Syndrome 1a	Multiple Pterygium Syndrome, Autosomal Dominant CPSFS1A Contractures, Pterygia, And Spondylocarpostarsal Fusion Syndrome 1a Autosomal Dominant Disease Contractures, Pterygia, And Variable Skeletal Fusions Syndrome 1a Cpskf1a Pterygium Syndrome, Multiple Autosomal Dominant Arthrogryposis, Distal, Type 8, Formerly Da8, Formerly Autosomal Dominant Multiple Pterygium Syndrome Distal Arthrogryposis Type 8 Arthrogryposis, Distal, Type 8 Da8 Pterygium Syndrome, Multiple, Autosomal Dominant Autosomal Dominant Disorder
Myositis Ossificans	Myisitis Ossificans Ossification - Muscle
Synostoses, Tarsal, Carpal, And Digital	Calcaneonavicular Coalition Multiple Synostosis Syndrome Synostoses, Tarsal, Carpal And Digital
Histone Mutated Tumor	Histone Mutated Tumour
Joubert Syndrome 21	JBTS21 Joubert Syndrome, Type 21
Gastric Adenocarcinoma	Adenocarcinoma Of Stomach Stomach Adenocarcinoma Adenocarcinoma Gastric Intestinal Type Adenocarcinoma Of Unspecified Site Diffuse Type Adenocarcinoma Of Unspecified Site
Osseous Heteroplasia, Progressive	Progressive Osseous Heteroplasia POH Osteoma Cutis Familial Ectopic Ossification Ectopic Ossification Familial Type Ectopic Ossification Heterotopic Ossification Ectopic Ossification, Familial Cutaneous Ossification Myositis Ossificans Progressiva Osteodermia Osteosis Cutis Ossification Heterotopic Heteroplasia, Osseous, Progressive Fibrodysplasia Ossificans Progressiva
Tarsal-Carpal Coalition Syndrome	TCC Tarsal Carpal Coalition Syndrome Nog-Related-Symphalangism Spectrum Disorder
Brachydactyly, Type A2	Brachydactyly Type A2 BDA2 Mohr-Wriedt Type Brachydactyly Brachymesophalangy Ii Brachymesophalangy Type 2 Brachymesophalangy 2 Brachydactyly, Mohr-Wriedt Type Brachydactyly A2
Brachydactyly, Type B2	Brachydactyly Type B2 BDB2 Brachydactyly B2
Arteriovenous Malformation	Arteriovenous Malformations Arteriovenous Hemangioma Cirsoid Aneurysm Racemose Aneurysm Racemose Angioma Racemose Hemangioma Congenital Arteriovenous Malformation
Hemochromatosis Type 2	Juvenile Hemochromatosis Juvenile Hereditary Hemochromatosis Hfe2 Jhh Hemochromatosis Juvenile Iron Overload Disease Juvenile Hemochromatosis, Juvenile Hemochromatosis, Type 2 Hemochromatosis Hemochromatosis, Type 1
Double Outlet Right Ventricle	Double Outlet Right Ventricle With Subpulmonary Ventricular Septal Defect Taussig-Bing Syndrome Dextrotransposition Of Aorta Taussig-Bing Syndrome Or Defect Dorv Dorv With Subpulmonary Vsd Dorv-Tga Double Outlet Right Ventricle With Transposition Of The Great Arteries Double Outlet Right Ventricle With Subpulmonary Interventricular Communication, Transposition Type Taussig-Bing Heart Taussig-Bing Malformation Taussig-Bing Complex Taussig-Bing Defect Taussig-Bing Double Outlet Right Ventricle With Remote Ventricular Septal Defect Double Outlet Right Ventricle With Uncommitted Ventricular Septal Defect Double Outlet Right Ventricle With Non-Committed Interventricular Communication Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication Without Pulmonary Stenosis Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication And Pulmonary Stenosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-109179A	Itacnosertib hydrochloride	Inhibitor	99.43%	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990022	Prafnosbart	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112815	ALK2-IN-2	Inhibitor	99.93%	Unkown
HY-109179	Itacnosertib	Inhibitor	99.06%	Unkown
HY-RS00242	ACVR1C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00243	Acvr1c Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00236	ACVR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00237	Acvr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00238	Acvr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00239	ACVR1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00240	Acvr1b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00241	Acvr1b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00244	Acvr1c Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W064657	Momelotinib dihydrochloride	Inhibitor	99.56%	Unkown
HY-174784	Human ACVR1C mRNA		/	Unkown
HY-174785	Human ACVR1B mRNA		/	Unkown
HY-174786	Human ACVR1 mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ACVR1	VGNC	VGNC:37561
Mus musculus	ACVR1	MGD	MGI:87911
Macaca mulatta	ACVR1	VGNC	VGNC:69438
Rattus norvegicus	ACVR1	RGD	RGD:620200
Felis catus	ACVR1	VGNC	VGNC:59562
Bos taurus	ACVR1	VGNC	VGNC:25592
Others	ACVR1	NCBI