TRIP4 - thyroid hormone receptor interactor 4 Gene

Also Known as ASC1; ASC-1; MDCDC; SMABF1; ZC2HC5; HsT17391

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9325

About TRIP4

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:64,387,836-64,455,303 (from NCBI)

This gene has 12 transcripts (splice variants), 207 orthologues and is associated with 5 phenotypes. Ubiquitous expression in thyroid (RPKM 15.4), kidney (RPKM 11.6) and 25 other tissues.

Summary

This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as Thyroid Hormone Receptor and retinoid X receptor alpha, but not Glucocorticoid Receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1). [provided by RefSeq, Apr 2016]

TRIP4 Products (2)

mRNA	Protein	Name
NM_001321924.2	NP_001308853.1	activating signal cointegrator 1 isoform 2
NM_016213.5	NP_057297.2	activating signal cointegrator 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables histone acetyltransferase binding	IPI IPI: Inferred from physical interaction	25219498	GOA
enables nuclear estrogen receptor binding	IPI IPI: Inferred from physical interaction	25219498	GOA
enables nuclear receptor binding	IDA IDA: Inferred from direct assay	10454579	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	25219498	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25219498	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20873783	GOA
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	25219498	GOA
enables ubiquitin-like protein ligase binding	IPI IPI: Inferred from physical interaction	25219498	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in estrogen receptor signaling pathway	IDA IDA: Inferred from direct assay	25219498	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	25219498	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12077347	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	26924529	GOA
involved in rescue of stalled ribosome	IDA IDA: Inferred from direct assay	32579943	GOA
involved in rescue of stalled ribosome	IMP IMP: Inferred from mutant phenotype	32099016	GOA
involved in ribosome disassembly	IDA IDA: Inferred from direct assay	32579943	GOA
involved in ribosome-associated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	32099016	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of activating signal cointegrator 1 complex	IDA IDA: Inferred from direct assay	12077347	GOA
colocalizes with centrosome	IDA IDA: Inferred from direct assay	20873783	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10454579	GOA
located in neuromuscular junction	IMP IMP: Inferred from mutant phenotype	26924529	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10454579	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	20873783	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIP4 Protein Structure

zf-C2HC5

ASCH

0
100
200
300
400
500
581 a.a.

Protein Preferred Names	Protein Names
activating signal cointegrator 1	TR-interacting protein 4

TRIP4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86772	ASC1 Antibody (YA6465)	WB, IHC-P	Human, Rat

Related Diseases

Diseases	Alias
Muscular Dystrophy, Congenital, Davignon-Chauveau Type	Congenital Muscular Dystrophy-Respiratory Failure-Skin Abnormalities-Joint Hyperlaxity Syndrome MDCDC Congenital Muscular Dystrophy, Davignon-Chauveau Type
Spinal Muscular Atrophy With Congenital Bone Fractures 1	SMABF1 Spinal Muscular Atrophy, Type I, With Congenital Bone Fractures Spinal Muscular Atrophy Type 1 With Congenital Bone Fractures Sma1 With Congenital Bone Fractures Atrophy, Muscular, Spinal, With Congenital Bone Fractures, Type 1
Prenatal-Onset Spinal Muscular Atrophy With Congenital Bone Fractures	Smabf
Muscular Atrophy	Muscle Wasting Amyotrophia Wasting - Muscle Skeletal Muscle Atrophy
Spinal Muscular Atrophy	Sma 5q Sma Proximal Sma Sma-Associated Sma Spinal Amyotrophies Spinal Amyotrophy Spinal Muscle Degeneration Spinal Muscle Wasting Muscular Atrophy Spinal Atrophy, Muscular, Spinal Hereditary Motor Neuronopathy Progressive Muscular Atrophy Sma - [Spinal Muscular Atrophy]
Postcholecystectomy Syndrome	Post Cholecystectomy Syndrome
Congenital Contractures	Congenital Contracture
Beukes Hip Dysplasia	Hip Dysplasia, Beukes Type Beukes Familial Hip Dysplasia BFHD Cilliers-Beighton Syndrome Osteoarthropathy, Premature Degenerative, Of Hip Premature Degenerative Osteoarthropathy Of The Hip BHD Beukes Type Hip Dysplasia Hip Dysplasia Beukes Type Premature Degenerative Osteoarthropathy Dysplasia, Hip, Beukes Type
Respiratory Failure	Acute Respiratory Failure Chronic Respiratory Failure Respiratory Insufficiency Acute-On-Chronic Respiratory Failure Respiratory Disease Acute And Chronic Respiratory Failure Respiratory Insufficiency/Failure Chronic Respiratory Disease Pulmonary Valve Insufficiency Chronic Disease Of Respiratory System Respiration Disorders Respiratory Tract Diseases Lung Failure Nos Pulmonary Failure Arf - [Acute Respiratory Failure] Acute Respiratory Insufficiency Acute Pulmonary Insufficiency Acute Respiration Failure Chronic Respiration Failure
Distal Arthrogryposis	Arthrogryposis Multiplex Congenita Arthrogryposis Congenital Multiple Arthrogryposis Congenital Arthromyodysplasia Fibrous Ankylosis Of Multiple Joints Guerin-Stern Syndrome Guérin-Stern Syndrome Myodystrophia Fetalis Deformans Otto Syndrome Rocher-Sheldon Syndrome Rossi Syndrome Amc Multiple Congenital Arthrogryposis Arthrogryposis Syndrome Arthrogryposis, Distal Distal Arthrogryposis Syndrome Freeman-Sheldon Syndrome Arthrogryposis, Distal, Type 2b Congenital Multiplex Arthrogryposis Amyoplasia Congenita Congenital Amyoplasia Amc - [Arthrogryposis Multiplex Congenita]
Immunodeficiency 30	Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12rb1 Deficiency IMD30 Il12rb1 Deficiency Mendelian Susceptibility To Interleukin 12 Receptor Beta 1 Deficiency Msmd Due To Complete Il12rb1 Deficiency Msmd Due To Complete Interleukin 12 Receptor Beta 1 Deficiency Il-12râ1 Deficiency Mendelian Susceptibility To Mycobacterial Infections Due To Il12 Deficiency Immunodeficiency, Type 30
Multiminicore Disease	Multiminicore Myopathy Mmd Minicore Disease Minicore Myopathy Multi-Core Congenital Myopathy Multi-Core Disease Multi-Minicore Disease Multicore Disease Multicore Myopathy Minicore Myopathy With External Ophthalmoplegia
Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome	Jacobs Syndrome Arthropathy-Camptodactyly Syndrome Pericarditis-Arthropathy-Camptodactyly Syndrome Xyy Syndrome Pac Syndrome Cacp Syndrome CACP Fibrosing Serositis, Familial Camptodactyly-Arthropathy-Pericarditis Syndrome Cap Syndrome 47, Xyy Syndrome 47,Xyy Syndrome Double Y Syndrome Camptodactyly-Arthropathy-Coxa-Vara-Pericarditis Syndrome Hypertrophic Synovitis, Congenital Familial Congenital Familial Hypertrophic Synovitis Xyy Karyotype Y Disomy Yy Syndrome Familial Fibrosing Serositis Disomy Y Double Y Camptodactyly Arthropathy Coxa Vara Pericarditis Syndrome Arthropathy Camptodactyly Syndrome Camptodactyly Arthropathy Pericarditis Syndrome Pericarditis Arthropathy Camptodactyly Syndrome Jacob'S Syndrome 47,Xyy Cdags Syndrome
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15080	TRIP4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22881	Trip4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29395	Trip4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TRIP4	RGD	RGD:1306838
Bos taurus	TRIP4	VGNC	VGNC:36360
Felis catus	TRIP4	VGNC	VGNC:66562
Canis familiaris	TRIP4	VGNC	VGNC:47847
Macaca mulatta	TRIP4	VGNC	VGNC:78649
Mus musculus	TRIP4	MGD	MGI:1928469
Others	TRIP4	NCBI