GLFGAIAGFIENGWEGMIDG
GLFGAIAGFIENGWEGMIDG is an influenza hemagglutinin fusion peptide and membrane disruptor composed of 20 amino acids. GLFGAIAGFIENGWEGMIDG transiently adopts an activated double-helix conformation under low pH conditions; meanwhile, it self-assembles into oligomers with a stable trimeric core, which further form pentamers and hexamers capable of inducing membrane bending, thinning and long-range disruption. GLFGAIAGFIENGWEGMIDG promotes the protrusion of lipid tails and the penetration of polar heads in phospholipid membranes, and is widely used in influenza-related studies.
For research use only. We do not sell to patients.
- CAS No.: 117138-20-2
- Formula: C94H136N22O28S
- Molecular Weight:2054.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
GLFGAIAGFIENGWEGMIDG self-assembles into stable trimers, tetramers and pentamers at the POPC membrane interface; these oligomers adopt a parallel orientation relative to the membrane, and the larger the oligomer size, the more pronounced the induced membrane curvature and membrane thinning. Their stability and interactions depend on specific internal residues and membrane-facing residues[1].
GLFGAIAGFIENGWEGMIDG adopts an α-helical conformation in model lipid membranes, and an inverted V-shaped conformation in micelles and phospholipid bilayers, with Asn12 located near the membrane interface[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 117138-20-2
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Molecular Weight 2054.28
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Formula C94H136N22O28S
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SMILES
O=C(N[C@@H](CC(C)C)C(N[C@@H](CC1=CC=CC=C1)C(NCC(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(NCC(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CCSC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(O)=O)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN
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Sequence
Gly-Leu-Phe-Gly-Ala-Ile-Ala-Gly-Phe-Ile-Glu-Asn-Gly-Trp-Glu-Gly-Met-Ile-Asp-Gly
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Sequence Shortening
GLFGAIAGFIENGWEGMIDG
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GLFGAIAGFIENGWEGMIDG Related Classifications
HY-P12139 Related Classifications
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