GLUT1-IN-1
GLUT1-IN-1 is a glucose transporter 1 (GLUT1) inhibitor and has a GLUT1-specific inactivation ability. GLUT1-IN-1 exhibits concentration-dependent cytotoxicity for HeLa, A549 and HepG2 cells with IC50 values of 5.49 μM, 11.14 μM, and 8.73 μM, respectively. GLUT1-IN-1 can be used for the research of photodynamic therapy (PDT) and severals cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C25H31BF2I2N6O7
- 分子量:830.17
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
GLUT1 |
体外実験
GLUT1-IN-1(compound 8) (0-100 μM; 1 h) exhibits concentration-dependent cytotoxicity for HeLa, A549 and HepG2 cells with IC50 values of 5.49, 11.14, and 8.73 μM, respectively (Under light irradiation) [1].
GLUT1-IN-1 (0-100 μM; 1 h) possesses sufficient photosensitizing ability to exhibit significant cytotoxicity and that the glucose conjugation contributes to the suppression of the cytotoxicity of I2BODIPY[1].
GLUT1-IN-1 (8 μM, 10 μM; 1 h) selectively interacts with GLUT1 and oxidizes it under light irradiation, resulting in the conversion of GLUT1 into a derivative that is undetectable by immunoblotting analysis[1].
GLUT1-IN-1(1 h) has a GLUT1-specific inactivation ability and causes lightinduced cytotoxicity by modulating the EGFR/MAPK signaling pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa, A549 and HepG2 cells
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Concentration:0-100 μM
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Incubation Time:1 h
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Result:Exhibited a concentration-dependent cytotoxicity against these cancer cell lines under light irradiation.
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Cell Line:HeLa, A549 and HepG2 cells
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Concentration:10 μM
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Incubation Time:1 h
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Result:Not detected GLUT1in cell lines treated with 10 uM under light irradiation.
Reduced the levels of epidermal growth factor receptor tyrosine kinase (EGFR), phospho-ERK (Y204), and GLUT1 without affecting ERK, atubulin, and PCNA protein levels.
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Cell Line:HeLa, A549 and HepG2 cells
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Concentration:8, 10 μM
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Incubation Time:1 h
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Result:Observed a reduction in the intensity of the fluorescent signals due to glucose transporter 1 (GLUT1).
化学情報
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分子量 830.17
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分子式 C25H31BF2I2N6O7
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SMILES
OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)OCCN2N=NC(CNC(CCC3=[N]4C(C=C3I)=CC5=C(C(I)=C(N5B4(F)F)C)C)=O)=C2)O)O)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
GLUT1-IN-1 関連分類
HY-151486 関連分類
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