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GSK-1292263 hydrochloride

7 Cited Publications
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Based on 7 publication(s) in Google Scholar

GSK-1292263 (hydrochloride) is an orally active GPR119 agonist (pEC50 of approximately 6.9 and 6.7 nM for human and rat GPR119, respectively). GSK-1292263 is used in the research of type 2 diabetes and dyslipidemia.

For research use only. We do not sell to patients.

  • CAS No.: 1032824-54-6
  • Formula: C23H29ClN4O4S
  • Molecular Weight:493.02
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • GSK-1292263 hydrochloride Chemical Structure
    GSK-1292263 hydrochloride Chemical Structure
  • Experimental Validation Results for GSK-1292263 hydrochloride
  • Experimental Validation Results for GSK-1292263 hydrochloride
CAS No.: 1032824-54-6
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  • GSK-1292263 hydrochloride Chemical Structure
    GSK-1292263 hydrochloride Chemical Structure
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    GSK-1292263 hydrochloride purchased from MedChemExpress. Usage Cited in: FASEB J. 2016 Jan;30(1):324-35. [Abstract]

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     Treatment with 2 synthetic GPR119 agonists, MBX-2982 (MBX) and GSK1292263 (GSK), suppresses T090-induced SREBP-1 expression and mRNA levels of SREBP-1 target genes such as FAS, ACC, and SCD-1.

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    GSK-1292263 hydrochloride purchased from MedChemExpress. Usage Cited in: College of Pharmacy. Seoul National University. 2015 Aug.

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     Effects of GPR119 ligands on T090-induced pSREBP-1 and lipogenic enzymes expression. Primary cultured hepatocytes from GPR119-WT and -KO mice and HepG2 cells are pretreated with two GPR119 ligands [(MBX (MBX-2982) or GSK (GSK1292263)] for 30 min and the cells are exposed to T090 for 12 h.

  • GSK-1292263 hydrochloride