2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. Histamine H4 receptor antagonist-2

Histamine H4 receptor antagonist-2 serves as a potent activator of p53, demonstrating significant antitumor efficacy.

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Histamine H4 receptor antagonist-2

Histamine H4 receptor antagonist-2 Chemical Structure

CAS No. : 379247-14-0

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Based on 1 publication(s) in Google Scholar

Histamine H4 receptor antagonist-2 Related Antibodies

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Description

Histamine H4 receptor antagonist-2 serves as a potent activator of p53, demonstrating significant antitumor efficacy.

Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
8.35 μM
Compound: BMH-7
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 34954595]
HUVEC IC50
20.6 μM
Compound: BMH-7
Antiproliferative activity against human HUVEC cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HUVEC cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 34954595]
HeLa IC50
20.19 μM
Compound: 5ab; BMH-7
Antiproliferative activity against human HeLa cells by MTT assay
Antiproliferative activity against human HeLa cells by MTT assay
[PMID: 28745887]
HepG2 IC50
11.46 μM
Compound: 5ab; BMH-7
Antiproliferative activity against human HepG2 cells by MTT assay
Antiproliferative activity against human HepG2 cells by MTT assay
[PMID: 28745887]
HepG2 IC50
5.25 μM
Compound: BMH-7
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 34954595]
L02 IC50
20.3 μM
Compound: BMH-7
Antiproliferative activity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 34954595]
MCF7 IC50
7.56 μM
Compound: BMH-7
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 34954595]
MGC-803 IC50
10.66 μM
Compound: 5ab; BMH-7
Antiproliferative activity against human MGC803 cells by MTT assay
Antiproliferative activity against human MGC803 cells by MTT assay
[PMID: 28745887]
NCI-H460 IC50
16.97 μM
Compound: 5ab; BMH-7
Antiproliferative activity against human NCI-H460 cells by MTT assay
Antiproliferative activity against human NCI-H460 cells by MTT assay
[PMID: 28745887]
PC-3 IC50
15.1 μM
Compound: BMH-7
Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 34954595]
T-24 IC50
14.54 μM
Compound: 5ab; BMH-7
Antiproliferative activity against human T24 cells by MTT assay
Antiproliferative activity against human T24 cells by MTT assay
[PMID: 28745887]
Molecular Weight

347.41

Formula

C20H21N5O
CAS No.
SMILES

O=C1N(C2=NC3=C1C=CC=C3)N=C(C4=C2C=CC=C4)NCCCN(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Histamine H4 receptor antagonist-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Histamine H4 receptor antagonist-2379247-14-0Histamine ReceptorInhibitorinhibitorinhibit

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