Histamine H4 receptor antagonist-2
Histamine H4 receptor antagonist-2 serves as a potent activator of p53, demonstrating significant antitumor efficacy.
For research use only. We do not sell to patients.
- CAS No.: 379247-14-0
- Formula: C20H21N5O
- Molecular Weight:347.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Histamine Receptor Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
8.35 μM
Compound: BMH-7
|
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
|
[PMID: 34954595] |
| HeLa | IC50 |
20.19 μM
Compound: 5ab; BMH-7
|
Antiproliferative activity against human HeLa cells by MTT assay
Antiproliferative activity against human HeLa cells by MTT assay
|
[PMID: 28745887] |
| HepG2 | IC50 |
11.46 μM
Compound: 5ab; BMH-7
|
Antiproliferative activity against human HepG2 cells by MTT assay
Antiproliferative activity against human HepG2 cells by MTT assay
|
[PMID: 28745887] |
| HepG2 | IC50 |
5.25 μM
Compound: BMH-7
|
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
|
[PMID: 34954595] |
| HUVEC | IC50 |
20.6 μM
Compound: BMH-7
|
Antiproliferative activity against human HUVEC cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HUVEC cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
|
[PMID: 34954595] |
| L02 | IC50 |
20.3 μM
Compound: BMH-7
|
Antiproliferative activity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
|
[PMID: 34954595] |
| MCF7 | IC50 |
7.56 μM
Compound: BMH-7
|
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
|
[PMID: 34954595] |
| MGC-803 | IC50 |
10.66 μM
Compound: 5ab; BMH-7
|
Antiproliferative activity against human MGC803 cells by MTT assay
Antiproliferative activity against human MGC803 cells by MTT assay
|
[PMID: 28745887] |
| NCI-H460 | IC50 |
16.97 μM
Compound: 5ab; BMH-7
|
Antiproliferative activity against human NCI-H460 cells by MTT assay
Antiproliferative activity against human NCI-H460 cells by MTT assay
|
[PMID: 28745887] |
| PC-3 | IC50 |
15.1 μM
Compound: BMH-7
|
Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
|
[PMID: 34954595] |
| T-24 | IC50 |
14.54 μM
Compound: 5ab; BMH-7
|
Antiproliferative activity against human T24 cells by MTT assay
Antiproliferative activity against human T24 cells by MTT assay
|
[PMID: 28745887] |
Chemical Information
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CAS No. 379247-14-0
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Molecular Weight 347.41
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Formula C20H21N5O
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SMILES
O=C1N(C2=NC3=C1C=CC=C3)N=C(C4=C2C=CC=C4)NCCCN(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)