F10 - coagulation factor X Gene

Also Known as FX; FXA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2159

About F10

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,122,799-113,149,529 (from NCBI)

This gene has 7 transcripts (splice variants), 236 orthologues, 16 paralogues and is associated with 2 phenotypes. Broad expression in liver (RPKM 44.8), ovary (RPKM 13.4) and 16 other tissues.

Summary

This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the Other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by Factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to Thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]

F10 Products (3)

mRNA Protein Name
NM_000504.4 NP_000495.1 coagulation factor X isoform 1 preproprotein
NM_001312674.2 NP_001299603.1 coagulation factor X isoform 2 precursor
NM_001312675.2 NP_001299604.1 coagulation factor X isoform 3 precursor
Molecular Function GO Annotation Evidence References Source
enables phospholipid binding IDA
IDA: Inferred from direct assay
17469850 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
6323392 GOA
enables serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
17469850 GOA
enables serine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
12574802 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of TOR signaling IDA
IDA: Inferred from direct assay
18612547 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

F10 Protein Structure

Gla

Gla: Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain (45 - 86)

EGF

EGF: EGF-like domain (90 - 120)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (129 - 164)

Trypsin

Trypsin: Trypsin (235 - 462)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 488 a.a.
Protein Preferred Names Protein Names

coagulation factor X

  • Stuart-Prower factor

F10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
F10 P00742 NOTCH2NLC Homo sapiens P0DPK4 32296183
Intra
F10 P00742 NOTCH2NLC Homo sapiens P0DPK4 32296183
Intra
F10 P00742 NOTCH2NLC Homo sapiens P0DPK4 32296183
Intra
F10 P00742 UBQLN2 Homo sapiens Q9UHD9 32296183
Intra
F10 P00742 UBQLN2 Homo sapiens Q9UHD9 32296183
Intra
F10 P00742 UBQLN2 Homo sapiens Q9UHD9 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant F10 Proteins

Cat. No. Product Name Accession Purity
HY-P7860 Coagulation Factor X/F10 Protein, Human (HEK293, Fc) P00742 (N32-K488) ≥ 90%, as determined by reducing SDS-PAGE.

F10 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81604 Factor X Antibody (YA1349) WB, IHC-P Human

Related Diseases

Diseases Alias
Factor X Deficiency
  • Stuart-Prower Factor Deficiency

  • F10 Deficiency

  • Congenital Stuart Factor Deficiency

  • Factor X Deficiency, Congenital

  • Congenital Factor X Deficiency

  • Disease, Stuart-Prower

  • Stuart Factor Deficiency, Congenital

  • FA10D

  • Factor 10 Deficiency

  • Deficiency, Factor X

  • Hereditary Factor X Deficiency Disease

  • Deficiency Of Factor X

  • Stuart Deficiency Disease

  • Stuart Prower Deficiency

  • Stuart-Prower Disease

Hemophilia B
  • Christmas Disease

  • Factor Ix Deficiency

  • F9 Deficiency

  • HEMB

  • Plasma Thromboplastin Component Deficiency

  • Congenital Factor Ix Deficiency

  • Mild Hemophilia B

  • Severe Hemophilia B

  • Congenital Factor Ix Disorder

  • Deficiency, Functional Factor Ix

  • Hem B

  • Mild Congenital F9 Deficiency

  • Mild Congenital Factor Ix Deficiency

  • Moderate Hemophilia B

  • Moderate Congenital F9 Deficiency

  • Moderate Congenital Factor Ix Deficiency

  • Severe Congenital F9 Deficiency

  • Severe Congenital Factor Ix Deficiency

  • Bleeding Disorder In Hemophilia B Carriers

  • Congenital F9 Deficiency

  • Recessive X-Linked Hemophilia B

Scott Syndrome
  • SCTS

  • Bdplt7

  • Prothrombin Consumption Deficiency

  • Bleeding Abnormality Due To Deficiency Of Platelet Binding Of Factor X

  • Bleeding Disorder, Platelet-Type, 7

  • Prothrombin Conversion Defect, Familial

  • Prothrombin Consumption Inhibitor, Familial

  • Bleeding Abnormality Due To Deficiency Of Platelet Biding Of Factor X

  • Familial Prothrombin Consumption Inhibitor

  • Familial Prothrombin Conversion Defect

  • Platelet-Type Bleeding Disorder 7

  • Platelet Factor X Receptor Deficiency

  • Bleeding Disorder Platelet-Type 7

  • Prothrombin Consumption Inhibitor Familial

  • Prothrombin Conversion Defect Familial

Hemorrhagic Disease
  • Hemorrhagic Disorders

  • Hemorrhagic Diathesis

  • Hemorrhagic Diseases

  • Bleeding Tendency

  • Acquired Coagulation Factor Inhibitor Disorder

  • Acquired Inhibitor Of Coagulation

  • Antithrombinaemia

  • Antithromboplastinogenaemia

  • Circulating Anticoagulant Disorder

  • Haemorrhagic Disorder Due To Antithrombinaemia

  • Haemorrhagic Disorder Due To Excess Administered Heparin

  • Antithromboplastinaemia

  • Haemorrhagic Disorder Due To Hyperheparinemia

Hemophilia A
  • Factor Viii Deficiency

  • Haemophilia A

  • Mild Hemophilia A

  • HEMA

  • Hemophilia, Classic

  • Classic Hemophilia

  • Factor 8 Deficiency

  • Severe Hemophilia A

  • Classical Hemophilia

  • Hem A

  • Hemophilia A, Congenital

  • Mild Congenital F8 Deficiency

  • Mild Congenital Factor Viii Deficiency

  • Severe Congenital F8 Deficiency

  • Severe Congenital Factor Viii Deficiency

  • Moderate Hemophilia A

  • Moderate Congenital F8 Deficiency

  • Moderate Congenital Factor Viii Deficiency

  • Bleeding Disorder In Hemophilia A Carriers

  • Congenital F8 Deficiency

  • Congenital Fviii Deficiency

  • Congenital Factor Viii Deficiency

  • Mild Hereditary Factor Viii Deficiency Disease

  • Severe Hereditary Factor Viii Deficiency Disease

  • Ahg - [Antihaemophilic Globulin] Deficiency

  • Ahg - [Antihaemophilic Globulin] Deficiency Disease

  • Congenital Factor Viii Disorder

  • Sex-Linked Factor Viii Deficiency

  • Antihaemophilic Globulin Deficiency

  • Classic Haemophilia

  • Familial Haemophilia

  • Haemophilia

  • Hereditary Haemophilia

  • Subhaemophilia

  • Haemophilia Nos

Carotid Artery Thrombosis
Hemarthrosis
  • Haemarthrosis Of Shoulder Joint

  • Haemarthrosis Of The Ankle And Foot

  • Haemarthrosis Of The Pelvic Region And Thigh

  • Hemarthrosis Involving Ankle And Foot

  • Hemarthrosis Involving Forearm

  • Hemarthrosis Involving Hand

  • Hemarthrosis Involving Lower Leg

  • Hemarthrosis Involving Pelvic Region And Thigh

  • Hemarthrosis Involving Shoulder Region

  • Hemarthrosis Involving Upper Arm

  • Hemarthrosis Of Ankle And/Or Foot

  • Hemarthrosis Of Forearm

  • Hemarthrosis Of Hand

  • Hemarthrosis Of Lower Leg

  • Hemarthrosis Of Shoulder

  • Hemarthrosis Of Shoulder Region

  • Hemarthrosis Of The Ankle And Foot

  • Hemarthrosis Of The Ankle And/Or Foot

  • Hemarthrosis Of The Forearm

  • Hemarthrosis Of The Hand

  • Hemarthrosis Of The Lower Leg

  • Hemarthrosis Of The Pelvic Region And Thigh

  • Hemarthrosis Of The Shoulder Region

  • Hemarthrosis Of The Upper Arm

  • Hemarthrosis Of Upper Arm

Antithrombin Iii Deficiency
  • Hereditary Antithrombin Deficiency

  • Congenital Antithrombin Iii Deficiency

  • Hereditary Thrombophilia Due To Congenital Antithrombin Deficiency

  • AT3D

  • Thrombophilia Due To Antithrombin Iii Deficiency

  • Thph7

  • Hereditary Thrombophilia Due To Congenital Antithrombin 3 Deficiency

  • Thrombophilia 7 Due To Antithrombin Iii Deficiency

  • At Iii Deficiency

  • Congenital At-Iii Deficiency

  • Inherited Antithrombin Deficiency

  • Antithrombin 3 Deficiency

  • Antithrombin Deficiency

  • Antithrombin-Iii Deficiency

  • At-Iii Deficiency

  • Thrombophilia Due To Antithrombin-Iii Deficiency

Myocardial Infarction
  • Heart Attack

  • Myocardial Infarction, Susceptibility To

  • Myocardial Infarction 1

  • Myocardial Infarction, Protection Against

  • Myocardial Infarction, Decreased Susceptibility To

  • Myocardial Infarction, Decreased

  • Myocardial Infarct

  • MCI1

  • Premature Myocardial Infarction

  • Myocardial Infarction, Susceptibility To, Type 1

Thrombocytopenia
  • Low Platelet Count

  • Low Platelets

  • Decreased Platelets

  • Platelet Dysfunction Nos

Hemophilia
  • Haemophilia

  • Hemophilia, Familial

  • Hemophilia, Hereditary

  • Hemophilia A

  • Hemophilia, Nos

Antiphospholipid Syndrome
  • Antiphospholipid Antibody Syndrome

  • Hughes Syndrome

  • Familial Antiphospholipid Syndrome

  • Aps

  • Lupus Anticoagulant, Familial

  • Anti-Phospholipid Syndrome

  • Apls

  • Classic Apls

  • Classic Antiphospholipid Syndrome

  • Acromegaloid Facial Appearance Syndrome

  • Anticardiolipin Syndrome

Thrombosis
  • Thrombosis Of Blood Vessel

Thrombophilia
  • Hypercoagulability State

Prothrombin Deficiency, Congenital
  • Dysprothrombinemia

  • Hypoprothrombinemia

  • Congenital Factor Ii Deficiency

  • Prothrombin Deficiency

  • Factor Ii Deficiency

  • Congenital Prothrombin Deficiency

  • FA2D

  • Hypoprothrombinemias

  • Inherited Factor Ii Deficiency

  • Hereditary Factor Ii Deficiency Disease

Factor V Deficiency
  • Parahemophilia

  • Labile Factor Deficiency

  • Proaccelerin Deficiency

  • Owren Disease

  • Owren Parahemophilia

  • Quebec Platelet Disorder

  • Deficiency, Labile

  • Hereditary Hypoproaccelerinaemia

  • Owren'S Disease

  • Congenital Factor V Deficiency

  • FA5D

  • Factor 5 Deficiency

  • Deficiency, Factor V

Thrombophilia Due To Thrombin Defect
  • Venous Thromboembolism

  • Venous Thrombosis

  • Thrombophilia Due To Factor 2 Defect

  • Thromboembolism

  • THPH1

  • Thromboembolism, Susceptibility To

  • Venous Thromboembolism, Susceptibility To

  • Venous Thrombosis, Protection Against

  • Prothrombin-Related Thrombophilia

  • Hyperprothrombinemia

  • Venous Thrombosis, Susceptibility To

  • Thrombophilia 1 Due To Thrombin Defect

  • F2-Related Thrombophilia

  • Factor Ii-Related Thrombophilia

  • Prothrombin 20210g>A Thrombophilia

  • Prothrombin G20210a Thrombophilia

  • Prothrombin Thrombophilia

Factor Vii Deficiency
  • Hypoproconvertinemia

  • F7 Deficiency

  • Congenital Proconvertin Deficiency

  • Congenital Factor Vii Deficiency

  • Factor 7 Deficiency

  • Deficiency, Stable

  • Proconvertin Deficiency

  • Prothrombin Conversion Accelerator Deficiency

  • Serum Prothrombin Conversion Accelerator Deficiency

  • Proconvertin Deficiency, Congenital

  • FA7D

  • Stable Disease

  • Deficiency, Factor Vii

Quebec Platelet Disorder
  • Factor V Quebec

  • QPD

  • Bdplt5

  • Bleeding Disorder, Platelet-Type, 5

  • Platelet-Type Bleeding Disorder 5

  • Bleeding Disorder Platelet-Type 5

  • Platelet Disorder, Quebec

Thrombophilia Due To Activated Protein C Resistance
  • Activated Protein C Resistance

  • Apc Resistance

  • THPH2

  • Thrombophilia Due To Deficiency Of Activated Protein C Cofactor

  • Proc Cofactor Deficiency

  • Pccf Deficiency

  • Thrombophilia V

  • Thrombophilia, Susceptibility To, Due To Factor V Leiden

  • Thrombophilia Due To Factor V Leiden

  • Thrombophilia 2 Due To Activated Protein C Resistance

  • Thrombophilia, Susceptibility To, Due To Activated Protein C Resistance

Atrial Fibrillation
  • A-Fib

  • Fibrillation, Atrial

  • Af - [Atrial Fibrillation]

  • Rapid Atrial Fibrillation

  • A Fib - [Atrial Fibrillation]

Protein Z Deficiency
Protein S Deficiency
  • Protein S Deficiency Disease

  • Hereditary Thrombophilia Due To Protein S Deficiency

Pulmonary Embolism
  • Pulmonary Artery Embolism

  • Pulmonary Embolus

  • Pulmonary Emboli

Afibrinogenemia, Congenital
  • Congenital Afibrinogenemia

  • Afibrinogenemia

  • Factor I Deficiency

  • Familial Afibrinogenemia

  • Hypofibrinogenemia, Congenital

  • Fibrinogen Deficiency

  • Afibrinogenemia Congenital

  • CAFBN

  • Congenital Hypofibrinogenemia

  • Hypofibrinogenemia

  • Complement Factor I Deficiency

Disseminated Intravascular Coagulation
  • Defibrination Syndrome

  • Dic

  • Diffuse Or Disseminated Intravascular Coagulation

  • Fibrinolytic Purpura

  • Consumption Coagulopathy

  • Diffuse Intravascular Coagulation

  • Dic - [Disseminated Intravascular Coagulation]

  • Disseminated Intravascular Coagulopathy

  • Fibrinolysis Nos

  • Thrombolytic Purpura

Glanzmann Thrombasthenia 1
  • Glanzmann Thrombasthenia

  • Thrombasthenia Of Glanzmann And Naegeli

  • Glanzmann'S Thrombasthenia

  • Bdplt2

  • Platelet Glycoprotein Iib-Iiia Deficiency

  • Deficiency Of Platelet Fibrinogen Receptor

  • GT1

  • Gt

  • Platelet Fibrinogen Receptor Deficiency

  • Glycoprotein Complex Iib-Iiia Deficiency

  • Deficiency Of Glycoprotein Complex Iib-Iiia

  • Glycoprotein Iib/Iiia Defect

  • Glanzmann Thrombasthenia, Type A

  • Thrombasthenia

  • Bleeding Disorder, Platelet-Type, 2

  • Gp Iib-Iiia Complex Deficiency

  • Deficiency Of Gp Iib-Iiia Complex

  • Platelet-Type Bleeding Disorder 2

  • Thrombocytasthenia

  • Deficiency Of Gp 2b 3a Complex

  • Diacyclothrombopathia 2b 3a

  • Glanzmann Thrombasthenia Type A

  • Platelet Fibrinogen Receptor, Deficiency Of

  • Platelet Glycoprotein 2b 3a Deficiency

  • Glanzmann Disease

  • Glanzmann-Naegeli Disorder

  • Hereditary Hemorrhagic Thrombasthenia

  • Hereditary Thrombasthenia

  • Bleeding Disorder Platelet-Type 2

Blood Platelet Disease
  • Platelet Disorder

  • Blood Platelet Disorders

  • Thrombocytopathy

  • Platelet Dysfunction

  • Platelet Disorders

  • Qualitative Platelet Deficiency

Puerperal Pulmonary Embolism
  • Obstetric Pulmonary Embolism

Acute Myocardial Infarction
  • Cardiac Attack

  • Heart Attack

Viral Hepatitis
  • Animal Viral Hepatitis

  • Hepatitis, Viral, Animal

  • Human Viral Hepatitis

  • Viral Hepatitis With Hepatic Coma

Pulmonary Artery Disease
  • Abnormality Of The Pulmonary Artery

Brachydactyly, Type D
  • Brachydactyly Type D

  • BDD

  • Stub Thumb

  • Brachydactyly D

Factor Viii Deficiency
  • Autosomal Hemophilia A

  • Hemophilia A

  • Autosomal Factor Viii Deficiency

  • Classic Hemophilia A

  • Congenital Factor Viii Disorder

  • Subhemophilia

  • Factor 8 Deficiency, Congenital

  • Factor Viii

Intracranial Thrombosis
  • Cerebral Thrombosis

  • Thrombosis Of Cerebral Veins

  • Cerebral Arterial Thrombosis

Gastroduodenal Crohn'S Disease
  • Upper Gi Crohn'S Disease

Post-Thrombotic Syndrome
  • Postphlebitic Syndrome

  • Postthrombotic Syndrome

  • Postphlebetic Syndrome With Inflammation

  • Postphlebetic Syndrome With Ulcer

  • Postphlebetic Syndrome With Ulcer And Inflammation

  • Venous Stress Disorder

Prothrombin Deficiency
  • Factor Ii Deficiency

  • Hypoprothrombinemia

  • Dysprothrombinemia

  • Deficiency, Prothrombin

  • Inherited Factor Ii Deficiency

  • Hereditary Factor Ii Deficiency Disease

Factor Xi Deficiency
  • Plasma Thromboplastin Antecedent Deficiency

  • Rosenthal Syndrome

  • Pta Deficiency

  • Hemophilia C

  • Rosenthal Factor Deficiency

  • F11 Deficiency

  • Congenital Factor Xi Deficiency

  • Hereditary Factor Xi Deficiency Disease

  • Haemophilia C

  • Factor Xi Deficiency, Autosomal Dominant

  • Rosenthal'S Disease

  • Factor 11 Deficiency

  • Factor Xi

  • Factor Xi Deficiency, Autosomal Recessive

  • Factor Xi Deficiency, Congenital

  • FA11D

  • Thromboplastin Antecedent Deficiency

  • Pta - [Plasma Thromboplastin Antecedent] Deficiency

  • Congenital Factor Xi Deficiency Disease

  • Rosenthal Disease

Temporal Lobe Neoplasm
  • Neoplasm Of Temporal Lobe

  • Malignant Neoplasm Of Temporal Lobe

  • Tumor Of Temporal Lobe

Peroxisome Biogenesis Disorder 11a
  • PBD11A

  • Peroxisome Biogenesis Disorder Complementation Group 13

  • PBD-CG13

  • Cg13

  • Pbd-Cgh

  • Peroxisome Biogenesis Disorder Complementation Group H

  • Peroxisome Biogenesis Disorder, Type 11a

  • Peroxisome Biogenesis Disorder, Complementation Group 13

Blood Coagulation Disease
  • Blood Coagulation Disorders

  • Coagulation Protein Disease

  • Inherited Blood Coagulation Disease

  • Postpartum Coagulation Defect

  • Postpartum Coagulation Defect With Delivery

  • Coagulation Protein Disorders

  • Puerperal Coagulopathy

Stroke, Ischemic
  • Cerebral Infarction

  • Stroke

  • Ischemic Stroke

  • Cerebrovascular Accident

  • Cerebral Infarction, Susceptibility To

  • Stroke, Ischemic, Susceptibility To

  • Cerebral Infarct

  • Ischemic Stroke, Susceptibility To

  • Stroke, Susceptibility To

  • Cva - Cerebral Infarction

  • ISCHSTR

  • Ischemic Cerebrovascular Accident

Heart Conduction Disease
  • Conduction Disorder Of The Heart

  • Heart Rhythm Disease

Alpha-2-Plasmin Inhibitor Deficiency
  • Plasmin Inhibitor Deficiency

  • Antiplasmin Deficiency

  • Antiplasmin Defiency

  • Anti-Plasmin Deficiency, Congenital

  • Antiplasmin Deficiency, Congenital

  • Congenital Alpha2-Antiplasmin Deficiency

  • APLID

  • Congenital Alpha2 Antiplasmin Deficiency

Lipoprotein Quantitative Trait Locus
  • Coronary Artery Disease

  • Coronary Artery Anomaly

  • Coronary Artery Disease, Susceptibility To

  • Myocardial Ischemia

  • Congenital Anomaly Of Coronary Artery

  • Coronary Arteriosclerosis

  • Coronary Disease

  • Coronary Heart Disease

  • Coronary Artery Disorder

  • LPAQTL

  • Lpa Deficiency, Congenital

  • Coronary Artery Abnormality

  • Coronary Artery Anomaly, Congenital

  • Chd

  • Coronary Syndrome

  • Congenital Malformations Of Coronary Vessels

  • Malformation Of Coronary Vessels

  • Congenital Coronary Artery Anomaly

  • Congenital Coronary Artery Deformity

  • Congenital Coronary Artery Disorder

  • Abnormal Coronary Artery

  • Congenital Coronary Artery Malposition

  • Congenital Coronary Disease

  • Congenital Anomaly Of Coronary Arteries

Patent Foramen Ovale
  • Atrial Septal Defect Within Oval Fossa

  • Foramen Ovale Patent

  • Ostium Secundum Atrial Septal Defect

  • Atrial Septal Defect, Ostium Secundum Type

  • Foramen Ovale, Patent

  • Defect, Patent Or Persistent, Ostium Secundum

  • Ostium Secundum Type Atrial Septal Defect

  • Persistent Ostium Secundum

  • Asd Ostium Secundum Type

  • Ostium Secundum Asd

  • Osasd

  • Asd, Ostium Secundum Type

  • Pfo - [Patent Foramen Ovale]

  • Open Foramen Ovale

  • Open Oval Foramen

  • Persistent Foramen Ovale

  • Secundum Atrial Septal Defect

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma