1. GPCR/G Protein
    Neuronal Signaling
  2. Melanocortin Receptor
  3. CCZ01048

CCZ01048 

Cat. No.: HY-P2336
Handling Instructions

CCZ01048, a α-melanocyte-stimulating hormone (α-MSH) analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. CCZ01048 shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 is a promising candidate for PET imaging of malignant melanoma.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CCZ01048 Chemical Structure

CCZ01048 Chemical Structure

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Description

CCZ01048, a α-melanocyte-stimulating hormone (α-MSH) analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. CCZ01048 shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 is a promising candidate for PET imaging of malignant melanoma[1].

In Vivo

The cationic Pip linker to Nle-CycMSHhex, CCZ01048, not only improves tumor uptake, but also generates high tumor-to-normal tissue contrast with PET imaging in a preclinical melanoma model[1].

Molecular Weight

1508.72

Formula

C₇₁H₁₀₅N₂₁O₁₆

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CCZ01048CCZ 01048CCZ-01048Melanocortin ReceptorMC ReceptormalignantmelanomatumorB16F10cellsPETimagingInhibitorinhibitorinhibit

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CCZ01048
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