Anti-Mouse NKG2D/CD314 Antibody (HMG2D)
Anti-Mouse NKG2D/CD314 Antibody (HMG2D) is an Armenian hamster-derived IgG antibody inhibitor, targeting to mouse NKG2D/CD314. Anti-Mouse NKG2D/CD314 Antibody (HMG2D) can block NKG2D. Anti-Mouse NKG2D/CD314 Antibody (HMG2D) can be used for the researches of cancer, infection, inflammation and immunology, such as B16F10 tumor, colitis and L. major parasites and lymphocytic choriomeningitis virus (LCMV) co-infection.
For research use only. We do not sell to patients.
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Armenian hamster IgG
Recommend Isotype Controls
Species Reactivity
Mouse
IC50 & Target
NKG2D/CD314
In Vivo
Anti-Mouse NKG2D/CD314 Antibody (HMG2D) (250 μg, i.p., twice weekly for 6 weeks) prolongs allograft survival and attenuates cardiac allograft vasculopathy grade companied with anti-CTLA-4 in heart allograft mice[2].
Anti-Mouse NKG2D/CD314 Antibody (HMG2D) (150 μg, i.p., twice weekly) hinders the Dacarbazine (HY-B0078) inhibiting effect in tumor growth in B16F10 tumor mice[3].
Anti-Mouse NKG2D/CD314 Antibody (HMG2D) (250 μg, i.p., 3 times weekly for 7 weeks) prevents the development of colitis in CD4+CD45RBhigh T cells transferred SCID mice[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:L. major parasites and lymphocytic choriomeningitis virus (LCMV) co-infected mice models[1]
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Dosage:200 μg
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Administration:Intraperitoneally injection, 3 days after infection and twice weekly thereafter
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Result:Completely blocked the increase in ear thickness.
Showed visibly smaller with less ulceration.
Restored control of parasite burden and CD8 T cells.
Led to a partial restoration in monocyte infiltration and completely blocked the excessive infiltration of neutrophils.
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Animal Model:Heart allograft mice models[2]
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Dosage:250 μg
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Administration:Intraperitoneally injection, twice weekly for 6 weeks, companied with anti-CTLA-4
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Result:Prolonged cardiac allograft survival and attenuated cardiac allograft vasculopathy grade.
Attenuated leucocyte infiltration and alloantibody IgM and IgG production.
Inhibited IL-6 expression.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo NKG2D blockade
Chemical Information
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Molecular Weight 150 kDa
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SMILES
[Anti-Mouse NKG2D/CD314 Antibody (HMG2D)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Crosby EJ, et al. Lymphocytic Choriomeningitis Virus Expands a Population of NKG2D+CD8+ T Cells That Exacerbates Disease in Mice Coinfected with Leishmania major. J Immunol. 2015 Oct 1;195(7):3301-10. [Content Brief]
[2]. Chen H, et al. NKG2D blockade attenuated cardiac allograft vasculopathy in a mouse model of cardiac transplantation. Clin Exp Immunol. 2013 Sep;173(3):544-52. [Content Brief]
[3]. Hervieu A, et al. Dacarbazine-mediated upregulation of NKG2D ligands on tumor cells activates NK and CD8 T cells and restrains melanoma growth. J Invest Dermatol. 2013 Feb;133(2):499-508. [Content Brief]
[4]. Ito Y, et al. Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis. Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G199-207. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse NKG2D/CD314 Antibody (HMG2D) Related Classifications
HY-P990804 Related Classifications
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