Klrk1 - killer cell lectin-like receptor subfamily K, member 1 Gene

Also Known as Nkg2d; NKG2-D; D6H12S2489E

Species: Mus musculus

Gene Type: protein coding
Gene ID: 27007

Summary

Enables several functions, including MHC class I protein binding activity; MHC class Ib receptor activity; and identical protein binding activity. Involved in positive regulation of natural killer cell mediated cytotoxicity. Acts upstream of or within several processes, including positive regulation of interferon-gamma production; positive regulation of nitric oxide biosynthetic process; and response to bacterium. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in tropical spastic paraparesis. Orthologous to several human genes including KLRC4-KLRK1 (KLRC4-KLRK1 readthrough). [provided by Alliance of Genome Resources, Apr 2022]

Klrk1 Products (3)

mRNA Protein Name
NM_001083322.2 NP_001076791.1 NKG2-D type II integral membrane protein isoform b
NM_001286018.1 NP_001272947.1 NKG2-D type II integral membrane protein isoform c
NM_033078.4 NP_149069.1 NKG2-D type II integral membrane protein isoform a
Protein Preferred Names Protein Names

NKG2-D type II integral membrane protein

  • NK cell receptor D

  • NKG2-D-activating NK receptor

  • natural killer cell group 2D

Recombinant Klrk1 Proteins

Cat. No. Product Name Accession Purity
HY-P72503 NKG2D/CD314 Protein, Mouse (HEK293, His) O54709 (F94-V232) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76513 NKG2D/CD314 Protein, Mouse (sf9, Fc) NP_001076791.1 (F77-V219) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P78330 NKG2D/CD314 Protein, Mouse (HEK293, Fc) O54709 (F90-V232) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07399 KLRK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17835 Klrk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24303 Klrk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990972 Azerutamig / Unkown
HY-P991003 Ingitamig Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Klrk1 NCBI NCBI:22914