Human enteropeptidase-IN-1
Human enteropeptidase-IN-1 (compound 6b) is a highly potent, orally active and low systemic exposure enteropeptidase inhibitor. Human enteropeptidase-IN-1 boosts the increase in fecal protein output, and exhibits potent body weight loss in diet-induced obese (DIO) rat model. Human enteropeptidase-IN-1 can be used for anti-obesity research.
For research use only. We do not sell to patients.
- CAS No.: 1802891-20-8
- Formula: C20H18N4O7
- Molecular Weight:426.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50(initial): 20 nM (enteropeptidase)[1]
IC50(app): 1.2 nM (enteropeptidase)[1]
Human enteropeptidase-IN-1 (compound 6b) has inhibitory activity against enteropeptidase with IC50(initial)* of 20 nM and IC50(app)** of 1.2 nM[1].
(*IC50(initial) refers to the inhibitory activity of human enteropeptidase after 6 min of incubation with the enzyme, substrate, and compound.)
(**IC50(app) refers to the apparent IC50 value after 120 min of incubation with the enzyme, substrate, and compound.)
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1802891-20-8
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Molecular Weight 426.38
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Formula C20H18N4O7
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SMILES
OC(C[C@]1(CC(C2=CC(OC(C3=CC=C(C=C3)NC(N)=N)=O)=CC=C2)=NO1)C(O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Human enteropeptidase-IN-1 Related Classifications
HY-147927 Related Classifications
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