2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. Hydroxy-PEG4-(CH2)2-Boc

Hydroxy-PEG4-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG4-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 191). Hydroxy-PEG4-(CH2)2-Boc is also a PROTAC linker that can be used in the synthesis of PROTACs.

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Hydroxy-PEG4-(CH2)2-Boc

Hydroxy-PEG4-(CH2)2-Boc Chemische Struktur

CAS. Nr. : 518044-32-1

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Based on 1 publication(s) in Google Scholar

Hydroxy-PEG4-(CH2)2-Boc Related Antibodies

Top Publications Citing Use of Products

Alle ADC Linker Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Alle PROTAC Linkers Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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Beschreibung

Hydroxy-PEG4-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG4-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 191). Hydroxy-PEG4-(CH2)2-Boc is also a PROTAC linker that can be used in the synthesis of PROTACs.

IC50 & Target[1]

Non-cleavable Linker

 

Alkyl/ether

 

PEGs

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hydroxy-PEG4-(CH2)2-Boc Related Antibodies
Molekulargewicht

322.39

Formel

C15H30O7
CAS. Nr.
Appearance

Liquid (Density: 1.04746 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)CCOCCOCCOCCOCCO
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Reinheit & Dokumentation

Purity: 99.34%

SDS (396 KB)

COA (239 KB) HNMR (130 KB) LCMS (97 KB) GC (251 KB)

Handling Instructions (2659 KB)
Verweise
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Hydroxy-PEG4-(CH2)2-Boc Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hydroxy-PEG4-(CH2)2-Boc518044-32-1ADC LinkerPROTAC LinkersAntibody-drug conjugates linkerADCLinkerWO2004008101A2Inhibitorinhibitorinhibit

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SAFETY DATA SHEET (SDS)

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