Hydroxy-PEG1-(CH2)2-Boc

Name: Hydroxy-PEG1-(CH2)2-Boc
Brand: MedChemExpress
SKU: HY-W055870
Rating: 4.5 (1 reviews)

Cat. No.: HY-W055870 Purity: ≥96.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Hydroxy-PEG1-(CH2)2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Hydroxy-PEG1-(CH2)2-Boc Chemical Structure

CAS No. : 671802-00-9

Size	Price	Stock	Quantity
250 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 40	In-stock	Estimated Time of Arrival: December 31
1 g	USD 64	In-stock	Estimated Time of Arrival: December 31
5 g		Get quote
10 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

Hydroxy-PEG1-(CH2)2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs	Alkyl/ether

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

190.24

Formula

C₉H₁₈O₄

CAS No.

671802-00-9

Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)CCOCCO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (525.65 mM; Need ultrasonic)

DMSO : 12.5 mg/mL (65.71 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.2565 mL	26.2826 mL	52.5652 mL
5 mM	1.0513 mL	5.2565 mL	10.5130 mL
10 mM	0.5257 mL	2.6283 mL	5.2565 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (525.65 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 97.46%

Select Batch:

Data Sheet (268 KB) SDS (393 KB)

COA (242 KB) HNMR (93 KB) GC (229 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	5.2565 mL	26.2826 mL	52.5652 mL	131.4129 mL
	5 mM	1.0513 mL	5.2565 mL	10.5130 mL	26.2826 mL
	10 mM	0.5257 mL	2.6283 mL	5.2565 mL	13.1413 mL
	15 mM	0.3504 mL	1.7522 mL	3.5043 mL	8.7609 mL
	20 mM	0.2628 mL	1.3141 mL	2.6283 mL	6.5706 mL
	25 mM	0.2103 mL	1.0513 mL	2.1026 mL	5.2565 mL
	30 mM	0.1752 mL	0.8761 mL	1.7522 mL	4.3804 mL
	40 mM	0.1314 mL	0.6571 mL	1.3141 mL	3.2853 mL
	50 mM	0.1051 mL	0.5257 mL	1.0513 mL	2.6283 mL
	60 mM	0.0876 mL	0.4380 mL	0.8761 mL	2.1902 mL
H₂O	80 mM	0.0657 mL	0.3285 mL	0.6571 mL	1.6427 mL
H₂O	100 mM	0.0526 mL	0.2628 mL	0.5257 mL	1.3141 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.