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Cat. No.: HY-125748

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CBM-301940

Name: CBM-301940
Brand: MedChemExpress
SKU: HY-125748
Price: 410.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Based on 1 publication(s) in Google Scholar

CBM-301940 (compound 5) is an orally active malonate CoA decarboxylase (MCD) inhibitor with IC₅₀ value of 23 nM. CBM-301940 can be used in the study of cardiovascular diseases.

For research use only. We do not sell to patients.

Purity : 99.4%
CAS No.: 902146-11-6
Formula: C₁₅H₂₀F₆N₂O₅
Molecular Weight:422.32

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

CBM-301940 Chemical Structure

CAS No.: 902146-11-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (1)
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

CBM-301940 (compound 5) is an orally active malonate CoA decarboxylase (MCD) inhibitor with IC₅₀ value of 23 nM. CBM-301940 can be used in the study of cardiovascular diseases^[1].

IC₅₀ & Target

Malonate CoA Decarboxylase (MCD)^[1]

Chemical Information

CAS No. 902146-11-6
Appearance Solid
Molecular Weight 422.32
Formula C₁₅H₂₀F₆N₂O₅
Color White to light yellow
SMILES

CC(NC(C1=NOC(C(C(F)(F)F)(O)C(F)(F)F)C1)=O)CC(OC(C)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Cancer Res

FASN Inhibition Enhances the Efficacy of Chemotherapy in Colorectal Cancer by Inhibiting the DNA Damage Response. [Abstract]

2026 Feb 9. PMID: 41661672

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cheng JF, et al. Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents. J Med Chem. 2006 Jul 13;49(14):4055-8. doi: 10.1021/jm0605029. PMID: 16821767. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (1)
Protocols
Purity & Documentation
References

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CBM-301940

Publications Citing Use of MedChemExpress (MCE) CBM-301940