257892-31-2
257892-31-2
Chemical Structure
N-Desmethyl rosiglitazone
Synonym(s): SB 237216
- CAS No.: 257892-31-2
- Formula:C17H17N3O3S
- Molecular Weight:343.40
IUPAC Name: 5-(4-(2-(pyridin-2-ylamino)ethoxy)benzyl)thiazolidine-2,4-dione
InChIKey: ZJQTVMXUIGXRMR-UHFFFAOYSA-N
SMILES: O=C1SC(CC2=CC=C(C=C2)OCCNC3=NC=CC=C3)C(N1)=O
Biological Activity: N-Desmethyl rosiglitazone (SB 237216) is a metabolite of Rosiglitazone (HY-17386), generated through demethylation by the cytochrome P450 enzyme system in liver microsomes. It retains partial PPARγ agonist activity and supports studies on the metabolism and pharmacokinetics of Rosiglitazone (HY-17386)[1].
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N-Desmethyl rosiglitazone | N-Desmethyl rosiglitazone (SB 237216) is a metabolite of Rosiglitazone (HY-17386), generated through demethylation by the cytochrome P450 enzyme system in liver microsomes. It retains partial PPARγ agonist activity and supports studies on the metabolism and pharmacokinetics of Rosiglitazone (HY-17386). | |||||||||||||||||||||
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N-Desmethyl rosiglitazone-d4 | N-Desmethyl rosiglitazone-d4 is the deuterium labeled N-Desmethyl rosiglitazone. | |||||||||||||||||||||
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