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Cat. No.: HY-142659

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IRE1α kinase-IN-6

IRE1α kinase-IN-6 is a potent IRE1α inhibitor with an IC₅₀ value of 4.4 nM.

For research use only. We do not sell to patients.

CAS No.: 2715123-88-7
Formula: C₂₅H₂₃Cl₂FN₆O₃S₂
Molecular Weight:609.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

IRE1α kinase-IN-6 Chemical Structure

CAS No.: 2715123-88-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

IRE1α kinase-IN-6 is a potent IRE1α inhibitor with an IC₅₀ value of 4.4 nM.

Chemical Information

CAS No. 2715123-88-7
Molecular Weight 609.52
Formula C₂₅H₂₃Cl₂FN₆O₃S₂
SMILES

FC(C(NS(=O)(C1=C(C=CC=C1)Cl)=O)=CC=C2Cl)=C2NC(C3=CSC(C3=NC=N4)=C4N[C@H]5CC[C@@H](CC5)N)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Beveridge RE, et al. Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1α Inhibitory Activity. ACS Med Chem Lett. 2020 Oct 16;11(12):2389-2396. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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IRE1α kinase-IN-6

4μ8C

STF-083010

KIRA6

IXA4

MKC8866

MKC3946

IRE1α kinase-IN-1

APY29

6-Bromo-2-hydroxy-3-methoxybenzaldehyde

B I09

MKC9989

IRE1α kinase-IN-2

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Bioz

IRE1α kinase-IN-6

4μ8C

STF-083010

KIRA6

IXA4

MKC8866

MKC3946

IRE1α kinase-IN-1

APY29

6-Bromo-2-hydroxy-3-methoxybenzaldehyde

B I09

MKC9989

IRE1α kinase-IN-2

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

IRE1α kinase-IN-6 Related Classifications

HY-142659 Related Classifications

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