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Cat. No.: HY-18509

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IRE1α kinase-IN-2

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

IRE1α kinase-IN-2 is a potent IRE1α kinase inhibitor, with an EC₅₀ of 0.82 μM. IRE1α kinase-IN-2 inhibits IRE1α kinase autophosphorylation (IC₅₀=3.12 μM). IRE1α kinase-IN-2 inhibits XBP1 mRNA splicing in the WT cell lines.

For research use only. We do not sell to patients.

Purity: 99.24%
CAS No.: 1414938-21-8
Formula: C₂₇H₂₃F₃N₆O
Molecular Weight:504.51

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

IRE1α kinase-IN-2 Chemical Structure

CAS No.: 1414938-21-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	>49 μM Compound: KIRA3	Cytotoxicity against HEK293 cells co-expressing XBP1u-mRNA by luciferase reporter gene assay Cytotoxicity against HEK293 cells co-expressing XBP1u-mRNA by luciferase reporter gene assay	[PMID: 30779566]
HEK293	IC₅₀	0.76 μM Compound: KIRA3	Inhibition of tunicamycin-induced IRE1alpha (unknown origin) expressed in HEK293 cells assessed as reduction in IRE1alpha-dependent splicing of XBP1u-luciferase mRNA by luciferase reporter gene assay Inhibition of tunicamycin-induced IRE1alpha (unknown origin) expressed in HEK293 cells assessed as reduction in IRE1alpha-dependent splicing of XBP1u-luciferase mRNA by luciferase reporter gene assay	[PMID: 30779566]

In Vitro

IRE1α kinase-IN-2 (compound 3) inhibits XBP1 mRNA splicing, even during ER stress^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1414938-21-8
Appearance Solid
Molecular Weight 504.51
Formula C₂₇H₂₃F₃N₆O
Color White to off-white
SMILES

NC1=NC=CN2C1=C(C(C3=C4C=CC=C3)=CC=C4NC(NC5=CC(C(F)(F)F)=CC=C5)=O)N=C2C(C)C
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Adv Sci (Weinh)

Chronic ER Stress Triggers Cell-Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia. [Abstract]

2025 Oct 23:e11573. PMID: 41126722

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (198.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Preparing Stock Solutions

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9821 mL

9.9106 mL

19.8212 mL

5 mM

0.3964 mL

1.9821 mL

3.9642 mL

10 mM

0.1982 mL

0.9911 mL

1.9821 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang L, Perera BG, Hari SB, et al. Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nat Chem Biol. 2012;8(12):982-989. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9821 mL	9.9106 mL	19.8212 mL	49.5530 mL
	5 mM	0.3964 mL	1.9821 mL	3.9642 mL	9.9106 mL
	10 mM	0.1982 mL	0.9911 mL	1.9821 mL	4.9553 mL
	15 mM	0.1321 mL	0.6607 mL	1.3214 mL	3.3035 mL
	20 mM	0.0991 mL	0.4955 mL	0.9911 mL	2.4777 mL
	25 mM	0.0793 mL	0.3964 mL	0.7928 mL	1.9821 mL
	30 mM	0.0661 mL	0.3304 mL	0.6607 mL	1.6518 mL
	40 mM	0.0496 mL	0.2478 mL	0.4955 mL	1.2388 mL
	50 mM	0.0396 mL	0.1982 mL	0.3964 mL	0.9911 mL
	60 mM	0.0330 mL	0.1652 mL	0.3304 mL	0.8259 mL
	80 mM	0.0248 mL	0.1239 mL	0.2478 mL	0.6194 mL
	100 mM	0.0198 mL	0.0991 mL	0.1982 mL	0.4955 mL

Keywords

IRE1α kinase-IN-2

1 Cited Publications

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Biological Activity
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Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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IRE1α kinase-IN-2

Cell Cycle/DNA Damage Compound Library

Kinase Inhibitor Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Endoplasmic Reticulum Stress Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Publications Citing Use of MedChemExpress (MCE) IRE1α kinase-IN-2

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

IRE1α kinase-IN-2

Cell Cycle/DNA Damage Compound Library

Kinase Inhibitor Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Endoplasmic Reticulum Stress Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Publications Citing Use of MedChemExpress (MCE) IRE1α kinase-IN-2

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

IRE1α kinase-IN-2 Related Classifications

Cat. No.: HY-18509