FZD6 - frizzled class receptor 6 Gene

Also Known as FZ6; FZ-6; HFZ6; NDNC1; NDNC10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8323

About FZD6

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:103,298,494-103,332,866 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues, 15 paralogues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 15.4), lung (RPKM 14.1) and 25 other tissues.

Summary

This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike Other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of Apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]

FZD6 Products (4)

mRNA	Protein	Name
NM_001164615.2	NP_001158087.1	frizzled-6 isoform a precursor
NM_001164616.2	NP_001158088.1	frizzled-6 isoform b
NM_001317796.2	NP_001304725.1	frizzled-6 isoform c
NM_003506.4	NP_003497.2	frizzled-6 isoform a precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables Wnt receptor activity	IDA IDA: Inferred from direct assay	10347172	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	1927703	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	22575959	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14747478	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	14747478	GOA
involved in non-canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	14747478	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FZD6 Protein Structure

Frizzled

0
200
400
600
706 a.a.

Protein Preferred Names	Protein Names
frizzled-6	frizzled 6, seven transmembrane spanning receptor

FZD6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FZD6	O60353	SFRP1	Homo sapiens	Q8N474	Anti Tag CoIP	10347172

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FZD6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74134	Frizzled-6 Protein, Human (HEK293, His)	O60353-1/NP_003497.2 (H19-V153)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74135	Frizzled-6 Protein, Human (HEK293, Fc)	O60353-1 (H19-V153)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Nail Disorder, Nonsyndromic Congenital, 1	Nonsyndromic Congenital Nail Disorder 1 Twenty-Nail Dystrophy Claw-Shaped Nails Nail Disorder, Nonsyndromic Congenital, 10 Onycholysis NDNC1 Onychauxis, Hyponychia, And Onycholysis Nonsyndromic Congenital Nail Disorder 10 Idiopathic Trachyonychia Twenty Nail Dystrophy Ndnc10 Onychodystrophy Totalis, Isolated Nail Disorder, Nonsyndromic Congenital, 10, Formerly Ndnc10, Formerly Autosomal Dominant Nail Dysplasia Nail Disorder, Nonsyndromic Congenital 1 Onychodystrophy Totalis Sandpaper Nails Trachyonychia Nail Disorder, Non-Syndromic Congenital, 1 Nail Disorder, Non-Syndromic Congenital, 10 Onychauxis Hyponychia And Onycholysis Nail Disorder, Nonsyndromic Congenital, Type 10 Detachment Of Nail Separation Of Nail Plate
Nail Disease	Nail Diseases Abnormality Of The Nail Nail Anomaly
Autosomal Recessive Nail Dysplasia
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Hydrops Fetalis, Nonimmune	Hydrops Fetalis Non-Immune Hydrops Fetalis NIHF Familial Non-Immune Hydrops Fetalis Hydrops Fetalis Nonimmune Idiopathic Hydrops Fetalis Hb Bart'S Hydrops Fetalis Alpha-Thalassemia Hydrops Fetalis Alpha-Thalassemia Major Hemoglobin Bart'S Hydrops Fetalis Homozygous Alpha0-Thalassemia Fetal Anasarca Fetal Hydrops Generalized Fetal Edema Hf Non-Immune Hf Non-Immune Fetal Edema Non-Immune Fetal Hydrops Hydrops Fetalis, Non-Immune Hemoglobin Bart'S Hydrops Syndrome
Nonsyndromic Congenital Nail Disorder	Nail Disorder, Nonsyndromic Congenital
Tethered Spinal Cord Syndrome	Spinal Dysraphism Tethered Cord Syndrome Occult Spinal Dysraphism Occult Spinal Dysraphism Sequence Segmental Vertebral Anomalies Tethered Spinal Cord Disease Tethered Cord Spina Bifida Occulta Cryptomerorachischisis Spina Bifida Occulta With Tethered Spinal Cord Sbo - [Spina Bifida Occulta]
Myelomeningocele	Meningomyelocele
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Robinow Syndrome	Acral Dysostosis With Facial And Genital Abnormalities Fetal Face Syndrome Robinow Dwarfism Mesomelic Dwarfism-Small Genitalia Syndrome Robinow-Silverman-Smith Syndrome Costovertebral Segmentation Defect With Mesomelia Covesdem Syndrome Robinow'S Syndrome Robinow-Silverman Syndrome
Anencephaly	Aprosencephaly Anencephalus Congenital Absence Of Brain Absence Of A Large Part Of The Brain And The Skull Anencephalia Anencephalic Monster Brain Absence Brain Agenesis Brain Aplasia Absent Brain Anencephalic Congenital Absence Of Cerebrum Congenital Hemicrania Incomplete Anencephaly
Sacral Defect With Anterior Meningocele	Caudal Regression Syndrome Caudal Regression Sequence Sacral Agenesis Caudal Dysgenesis Syndrome SDAM Caudal Dysplasia Sequence Caudal Dysplasia Sacral Agenesis Syndrome Sacral Regression Syndrome Sacral Defect And Anterior Sacral Meningocele Rudd Klimek Syndrome Sirenomelia
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Exudative Vitreoretinopathy	Familial Exudative Vitreoretinopathy Fevr Criswick-Schepens Syndrome Exudative Vitreoretinopathy, Familial Vitreoretinopathy, Exudative ) Exudative Vitreoretinopathy 1
Strabismus	Strabismus, Susceptibility To Strabismus, Susceptibility To, 1 Strabismus 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05182	FZD6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19132	Fzd6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25622	Fzd6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FZD6	RGD	RGD:628816
Canis familiaris	FZD6	VGNC	VGNC:41034
Felis catus	FZD6	VGNC	VGNC:62406
Mus musculus	FZD6	MGD	MGI:108474
Macaca mulatta	FZD6	VGNC	VGNC:72837
Bos taurus	FZD6	VGNC	VGNC:29170
Others	FZD6	NCBI