2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK Btk
  4. JAK3/BTK-IN-7

JAK3/BTK-IN-7 (XL-12) is a JAK3/BTK inhibitor with IC50 values of 2 nM and 14 nM, respectively. JAK3/BTK-IN-7 has anti-inflammatory activity and can be used in the study of rheumatoid arthritis.

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JAK3/BTK-IN-7

JAK3/BTK-IN-7 Estructura química

No. CAS : 2844387-16-0

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JAK3/BTK-IN-7 Related Antibodies

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Descripciòn

JAK3/BTK-IN-7 (XL-12) is a JAK3/BTK inhibitor with IC50 values of 2 nM and 14 nM, respectively. JAK3/BTK-IN-7 has anti-inflammatory activity and can be used in the study of rheumatoid arthritis[1].

IC50 & Target

IC50: 2 nM (JAK3)[1].
IC50: 14 nM (BTK)[1].
Cellular Effect
Cell Line Type Value Description References
BaF3 IC50
366.4 nM
Compound: XL-12
Antiproliferative activity against mouse BaF3 cells expressing JAK3 mutant assessed as inhibition of cell growth incubated for 72 hrs by Cell Titer-Glo assay
Antiproliferative activity against mouse BaF3 cells expressing JAK3 mutant assessed as inhibition of cell growth incubated for 72 hrs by Cell Titer-Glo assay
[PMID: 37944414]
Daudi IC50
689.9 nM
Compound: XL-12
Antiproliferative activity against human Daudi cells assessed as inhibition of cell growth incubated for 72 hrs by Cell Titer-Glo assay
Antiproliferative activity against human Daudi cells assessed as inhibition of cell growth incubated for 72 hrs by Cell Titer-Glo assay
[PMID: 37944414]
HUVEC IC50
27.31 μM
Compound: XL-12
Cytotoxicity against HUVEC cells incubated for 48 hrs by MTT assay
Cytotoxicity against HUVEC cells incubated for 48 hrs by MTT assay
[PMID: 37944414]
HUVEC IC50
40.59 μM
Compound: XL-12
Cytotoxicity against HUVEC cells incubated for 24 hrs by MTT assay
Cytotoxicity against HUVEC cells incubated for 24 hrs by MTT assay
[PMID: 37944414]
HUVEC IC50
50 μM
Compound: XL-12
Cytotoxicity against HUVEC cells incubated for 12 hrs by MTT assay
Cytotoxicity against HUVEC cells incubated for 12 hrs by MTT assay
[PMID: 37944414]
L02 IC50
28.19 μM
Compound: XL-12
Cytotoxicity against human L02 cells incubated for 24 hrs by MTT assay
Cytotoxicity against human L02 cells incubated for 24 hrs by MTT assay
[PMID: 37944414]
L02 IC50
69.92 μM
Compound: XL-12
Cytotoxicity against human L02 cells incubated for 12 hrs by MTT assay
Cytotoxicity against human L02 cells incubated for 12 hrs by MTT assay
[PMID: 37944414]
L02 IC50
9.61 μM
Compound: XL-12
Cytotoxicity against human L02 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human L02 cells incubated for 48 hrs by MTT assay
[PMID: 37944414]
NRK IC50
11.84 μM
Compound: XL-12
Cytotoxicity against rat NRK cells incubated for 48 hrs by MTT assay
Cytotoxicity against rat NRK cells incubated for 48 hrs by MTT assay
[PMID: 37944414]
NRK IC50
15.74 μM
Compound: XL-12
Cytotoxicity against rat NRK cells incubated for 24 hrs by MTT assay
Cytotoxicity against rat NRK cells incubated for 24 hrs by MTT assay
[PMID: 37944414]
NRK IC50
50.99 μM
Compound: XL-12
Cytotoxicity against rat NRK cells incubated for 12 hrs by MTT assay
Cytotoxicity against rat NRK cells incubated for 12 hrs by MTT assay
[PMID: 37944414]
RAW264.7 IC50
19.74 μM
Compound: XL-12
Cytotoxicity against mouse RAW264.7 cells incubated for 48 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells incubated for 48 hrs by MTT assay
[PMID: 37944414]
RAW264.7 IC50
50.55 μM
Compound: XL-12
Cytotoxicity against mouse RAW264.7 cells incubated for 24 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells incubated for 24 hrs by MTT assay
[PMID: 37944414]
RAW264.7 IC50
60.78 μM
Compound: XL-12
Cytotoxicity against mouse RAW264.7 cells incubated for 12 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells incubated for 12 hrs by MTT assay
[PMID: 37944414]
Peso molecular

554.60

Fòrmula

C29H30N8O4
No. CAS
SMILES

NC1=C2C(C3=C4C(OCO4)=C(C=C3)NC(C5=CC=C(C=C5)N(C)C)=O)=NN([C@H]6CN(CCC6)C(C=C)=O)C2=NC=N1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
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Referencias
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JAK3/BTK-IN-7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JAK3/BTK-IN-72844387-16-0JAKBtkJanus kinaseBruton tyrosine kinaseRheumatoid arthritis (RA)anti-inflammatoryInhibitorinhibitorinhibit

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Nombre del producto:
JAK3/BTK-IN-7
Cat. No.:
HY-163183
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