JNJ-28312141 hydrochloride

Cat. No.: HY-13496A: Ficha de datos Instrucciones de manejo
FAQs
Technical Support

JNJ-28312141 hydrochloride is an inhibitor for colony-stimulating factor-1 receptor (CSF-1R or FMS), with an IC₅₀ of 0.69 nM. JNJ-28312141 hydrochloride inhibits proliferation of BDBM, MV-4-11, M-o7e, TF-1 with an IC₅₀s of 2.6, 21, 41 and 150 nM, respectively. JNJ-28312141 hydrochloride exhibits anti-inflammatory activity in mouse arthritis model.

Para uso exclusivo en investigación. No vendemos a pacientes.

JNJ-28312141 hydrochloride Estructura química

No. CAS : 1149939-55-8

Tamaño		Stock
MOQ		Minimum order quantity
50 mg		Obtener un presupuesto
100 mg		Obtener un presupuesto
250 mg		Obtener un presupuesto
Other size		Obtener un presupuesto

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Other Forms of JNJ-28312141 hydrochloride:

JNJ-28312141 Obtener un presupuesto

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn	JNJ-28312141 hydrochloride is an inhibitor for colony-stimulating factor-1 receptor (CSF-1R or FMS), with an IC₅₀ of 0.69 nM. JNJ-28312141 hydrochloride inhibits proliferation of BDBM, MV-4-11, M-o7e, TF-1 with an IC₅₀s of 2.6, 21, 41 and 150 nM, respectively. JNJ-28312141 hydrochloride exhibits anti-inflammatory activity in mouse arthritis model^[1].
IC₅₀ & Target	IC₅₀: 0.69 nM (CSF-1R or FMS)^[1]
Peso molecular	497.03
Fòrmula	C₂₆H₃₃ClN₆O₂
No. CAS	1149939-55-8
SMILES	O=C(C1=NC(C#N)=CN1)NC2=C(C3=CCCCC3)C=C(C4CCN(C(CN(C)C)=O)CC4)C=C2.Cl
Envío	Room temperature in continental US; may vary elsewhere.
Almacenamiento	Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación	Ficha de datos (268 KB) Instrucciones de manejo (2659 KB)
Referencias	[1]. Illig CR, et al., Optimization of a potent class of arylamide colony-stimulating factor-1 receptor inhibitors leading to anti-inflammatory clinical candidate 4-cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141). J Med Chem. 2011 Nov 24;54(22):7860-83. [Content Brief]