ILF2 - interleukin enhancer binding factor 2 Gene

Also Known as NF45; PRO3063

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3608

About ILF2

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,661,788-153,670,993 (from NCBI)

This gene has 5 transcripts (splice variants), 248 orthologues and 14 paralogues. Ubiquitous expression in testis (RPKM 65.5), bone marrow (RPKM 58.7) and 25 other tissues.

Summary

The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein (NF45, ILF2) forms a complex with the 90 kDa interleukin enhancer-binding factor 3 (NF90, ILF3), and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the MicroRNA processing pathway. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14. [provided by RefSeq, Dec 2014]

ILF2 Products (2)

mRNA	Protein	Name
NM_001267809.2	NP_001254738.1	interleukin enhancer-binding factor 2 isoform 2
NM_004515.4	NP_004506.2	interleukin enhancer-binding factor 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	7519613	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	10574923	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9442054	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11739746	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleolus	IDA IDA: Inferred from direct assay	11790298	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21123651	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	17289661	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ILF2 Protein Structure

DZF

0
100
200
300
390 a.a.

Protein Preferred Names	Protein Names
interleukin enhancer-binding factor 2	interleukin enhancer binding factor 2, 45kD

ILF2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ILF2	Q12905	ZMYND12	Homo sapiens	Q9H0C1	Validated Y2H	32296183
Intra	ILF2	Q12905	ZMYND12	Homo sapiens	Q9H0C1	Y2H Prey Pooling	32296183
Intra	ILF2	Q12905	ZMYND12	Homo sapiens	Q9H0C1	Y2H Array	32296183
Intra	ILF2	Q12905	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	ILF2	Q12905	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	ILF2	Q12905	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	ILF2	Q12905	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	ILF2	Q12905	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	ILF2	Q12905	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	ILF2	Q12905	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	ILF2	Q12905	PPID	Homo sapiens	Q08752	Anti Tag CoIP	21146485
Intra	ILF2	Q12905	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	ILF2	Q12905	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	ILF2	Q12905	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	ILF2	Q12905	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	ILF2	Q12905	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

ILF2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82199	ILF2 Antibody (YA1944)	WB, IHC-P, IP, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Japanese Encephalitis	Japanese B Encephalitis Je Encephalitis Japanese Encephalitis, Japanese Russian Autumnal Encephalitis Je - [Japanese Encephalitis] Japanese Encephalitis Virus Disease Jbe - [Japanese B Encephalitis} B Type Encephalitis
Encephalitis	Mumps Encephalitis Mumps Meningoencephalitis Herpes Simplex Neuroinvasion Herpetic Encephalitis Herpetic Encephalopathy Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis Encephalitis Due To Herpesviridae Encephalitis Due To Herpesvirus Herpes Encephalitis Herpesviral Encephalitis Herpes Simplex Encephalitis Hsv - [Herpes Simplex Virus] Encephalitis Herpes Virus Encephalitis Simian B Disease Simian B Disorder Encephalitis Nec Idiopathic Encephalitis
Childhood Endodermal Sinus Tumor	Childhood Endodermal Sinus Neoplasm Childhood Endodermal Sinus Tumour Paediatric Yolk Sac Tumour Pediatric Yolk Sac Tumor Childhood Yolk Sac Tumor
Treacher Collins Syndrome 1	Treacher Collins Syndrome Mandibulofacial Dysostosis Treacher Collins-Franceschetti Syndrome Tcof Tcs Mfd1 Franceschetti-Klein Syndrome TCS1 Franceschetti Syndrome Franceschetti-Zwahlen-Klein Syndrome Zygoauromandibular Dysplasia Treacher-Collins Syndrome Mandibulofacial Dysostosis Without Limb Anomalies Bilateral And Symmetric Oto-Mandibular Dysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06785	ILF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29448	ILF2 Pig Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ILF2	MGD	MGI:1915031
Felis catus	ILF2	VGNC	VGNC:67790
Rattus norvegicus	ILF2	RGD	RGD:1305734
Macaca mulatta	ILF2	VGNC	VGNC:99982
Canis familiaris	ILF2	VGNC	VGNC:41999
Bos taurus	ILF2	VGNC	VGNC:30175
Others	ILF2	NCBI