Antibacterial agent 331
Antibacterial agent 331 is an antibacterial agent with anti-biofilm activity. Antibacterial agent 331 exhibits activity against a variety of Gram-positive and Gram-negative bacteria. Antibacterial agent 331 eliminates MRSE 62 and promotes the repair of infected wounds in mouse models. Antibacterial agent 331 can be used for research on infections.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C26H29FN6O5S
- 分子量:556.61
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Antibacterial agent 331 (compound A4) (24 h) potently inhibits the growth of standard Gram-positive bacterial strains (Listeria monocytogenes CMCC54004, Staphylococcus aureus ATCC29213, Enterococcus faecalis BNCC186300) and Gram-negative bacterial strains (Salmonella typhimurium SL1344, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 15442), with MIC values ranging from <0.0625 to 0.25 μg/mL[1].
Antibacterial agent 331 (24 h) potently inhibits the growth of clinically isolated drug-resistant Gram-positive strains (MRSA 62, L970, L971; MRSE 61, 62, 63; VRE 11, 12, 13), with MIC values ranging from 0.125 to 16 μg/mL[1].
Antibacterial agent 331 (8 μg/mL; 24 h) eliminates 58.1% of mature MRSE 62 biofilms[1].
Antibacterial agent 331 (24 h) exhibits low cytotoxicity against L929 mouse fibroblasts, with a CC50 value > 128 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:L929 mouse fibroblast cells
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Concentration:/
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Incubation Time:24 h
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Result:Did not significantly reduce L929 cell viability, with a CC50 value >128 μg/mL.
体内実験
Antibacterial agent 331 (50-100 mg/kg; p.o.; once daily; for 8 consecutive days) is well tolerated in Kunming mice, with no adverse effects on body weight, organ function or histomorphology observed[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Kunming mice (male, 5-6 weeks of age, 18-22 g for biosafety study; male, 20±2 g for skin infection study)[1]
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Dosage:2× MIC
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Administration:local; once daily; 9 days
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Result:Reduced MRSE 62 bacterial load by approximately 3.1 log10 relative to controls.
Enhanced wound healing, with a higher wound contraction rate on day 3 compared to controls and reference groups.
Induced minimal inflammatory cell infiltration and near-normal cell morphology in treated tissue, unlike control and ciprofloxacin groups with obvious inflammatory cell infiltration and tissue abnormalities.
化学情報
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分子量 556.61
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分子式 C26H29FN6O5S
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SMILES
NC1=CC(NC(SCCCCC(N2CCN(CC2)C3=C(C=C4C(C(C(O)=O)=CN(C4=C3)C5CC5)=O)F)=O)=N1)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antibacterial agent 331 関連分類
HY-182056 関連分類
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Keywords
- Antibacterial agent 331
- Antibacterial agent331
- Antibacterial agent-331
- Bacterial
- methicillin
- Staphylococcus epidermidis
- Listeria monocytogenes CMCC54004
- MRSE 62
- Escherichia coli ATCC 25922
- mouse model
- Salmonella typhimurium SL1344
- Staphylococcus aureus ATCC29213
- Enterococcus faecalis BNCC186300
- L929 mouse fibroblast cells
- Pseudomonas aeruginosa ATCC 15442
- Inhibitor
- inhibitor
- inhibit