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製品番号: HY-181135

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Bicyclo-GABA

Bicyclo-GABA is a selective betaine/GABA transporter 1 (BGT1) competitive, non-transported inhibitor with an IC₅₀ of 590 nM. Bicyclo-GABA exhibits low micromolar agonistic activity at α₁β₂γ₂ GABA_A receptors with an EC₅₀ of 5.1 μM. Bicyclo-GABA displays 129 times higher activity for BGT1 than GAT3. Bicyclo-GABA serves as a valuable tool compound for deciphering its elusive pharmacological role in the brain and periphery.

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CAS 番号: 1615763-33-1
分子式: C₇H₁₁NO₂
分子量:141.17

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Bicyclo-GABA 構造式

CAS 番号: 1615763-33-1

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.59 μM Compound: 4	Inhibition of human BGT1 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis Inhibition of human BGT1 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis	[PMID: 25147609]

体外実験

Bicyclo-GABA (0.1-10000 nM; 3 min) potently inhibits [³H]GABA uptake at human BGT1 (IC₅₀ = 1.5 μM)^[1].
Bicyclo-GABA (0-10 μM) acts as a non-transported competitive inhibitor of human BGT1 (K_B = 0.47 μM)^[1].
Bicyclo-GABA (0.01-100 μM) shows agonistic activity at human α₁β₂γ₂ GABA_A receptors (EC₅₀ = 5.1 μM)^[1].
Bicyclo-GABA modulates inhibitory activity at BGT1 and GAT3 mutants (IC₅₀ range: 0.040-610 μM) in the cell-based [³H]GABA uptake assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1615763-33-1
分子量 141.17
分子式 C₇H₁₁NO₂
SMILES

N[C@]12[C@](C2)([H])[C@H](CC1)C(O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Kickinger S, et al. Molecular Determinants and Pharmacological Analysis for a Class of Competitive Non-transported Bicyclic Inhibitors of the Betaine/GABA Transporter BGT1. Front Chem. 2021;9:736457. Published 2021 Sep 14. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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