CDK1-IN-5
CDK1-IN-5 (10h) is a selective CDK1 inhibitor with IC50s of 42.19, 188.71 and 354.15 nM for CDK1, CDK2 and CDK5, respectively. CDK1-IN-5 inhibits growth of cancer cells by affecting cell cycle. CDK1-IN-5 can be used for the research of cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3032997-20-6
- 分子式: C27H26ClN5OS
- 分子量:504.05
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
CDK1 42.19 nM (IC50) |
CDK2 188.71 nM (IC50) |
CDK5 354.15 nM (IC50) |
CDK1-IN-5 (0-10 μM; 24 h) inhibits the growth of various cancer cells[1]. CDK1-IN-5 (0-1 μM) inhibits CDK1, CDK2 and CDK5 with IC50s of 42.19, 188.71 and 354.15 nM, respectively[1]. CDK1-IN-5 (0-10 μM) inhibits AXL, PTK2B, FGFR, JAK1, IGF1R and BRAF kinases with IC50s of 5649, 8945, 2538, 2417, 8546 and 8138 nM, respectively[1]. CDK1-IN-5 (0.73 μM; 24 h) decreases CDK1 protein level in virto and affects cell cycle[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:PDAC, melanoma, leukemia, colon, and breast cancer cell lines
-
Concentration:0-10 μM
-
Incubation Time:24 hours
-
Result:Inhibited cell growth of PDAC, melanoma, leukemia, colon and breast cancer cells over 62%, and inhibited MDA-PATC53 and PL45 cells with IC50s of 0.73 and 1 μM, respectively.
-
Cell Line:MDA-PATC53 cell line
-
Concentration:0.73 μM
-
Incubation Time:24 hours
-
Result:Downregulated the CDK1 protein level compared to untreated cells.
-
Cell Line:MDA-PATC53 cell line
-
Concentration:0.73 μM
-
Incubation Time:24 hours
-
Result:Significantly arrested in G2/M phase of the cell cycle compared with the untreated cells.
化学情報
-
CAS 番号 3032997-20-6
-
分子量 504.05
-
分子式 C27H26ClN5OS
-
SMILES
S=C(N1CCN(C2=NN=C(CC3=CC=C(OC)C=C3)C4=C2C=CC=C4)CC1)NC5=CC=CC(Cl)=C5
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CDK1-IN-5 関連分類
HY-151409 関連分類
Powered by Bioz