TRDMT1 - tRNA aspartic acid methyltransferase 1 Gene

Also Known as DMNT2; DNMT2; PUMET; RNMT1; MHSAIIP

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 1787

About TRDMT1

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:17,137,336-17,201,672 (from NCBI)

This gene has 12 transcripts (splice variants), 201 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 1.0), endometrium (RPKM 0.6) and 25 other tissues.

Summary

This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa. [provided by RefSeq, Jun 2010]

TRDMT1 Products (8)

mRNA Protein Name
NM_001321006.2 NP_001307935.1 tRNA (cytosine(38)-C(5))-methyltransferase isoform f
NM_001321007.2 NP_001307936.1 tRNA (cytosine(38)-C(5))-methyltransferase isoform g
NM_001351219.2 NP_001338148.1 tRNA (cytosine(38)-C(5))-methyltransferase isoform h
NM_001351220.2 NP_001338149.1 tRNA (cytosine(38)-C(5))-methyltransferase isoform i
NM_001351221.2 NP_001338150.1 tRNA (cytosine(38)-C(5))-methyltransferase isoform j
NM_001351222.2 NP_001338151.1 tRNA (cytosine(38)-C(5))-methyltransferase isoform k
NM_001351223.2 NP_001338152.1 tRNA (cytosine(38)-C(5))-methyltransferase isoform k
NM_004412.7 NP_004403.1 tRNA (cytosine(38)-C(5))-methyltransferase isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables tRNA (cytidine-5-)-methyltransferase activity EXP
EXP: Inferred from Experiment
16424344 GOA
enables tRNA (cytidine-5-)-methyltransferase activity IDA
IDA: Inferred from direct assay
16424344 GOA
enables tRNA methyltransferase activity IDA
IDA: Inferred from direct assay
16424344 GOA
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within tRNA methylation IDA
IDA: Inferred from direct assay
16424344 GOA
involved in tRNA modification IDA
IDA: Inferred from direct assay
16424344 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in cytoplasm IDA
IDA: Inferred from direct assay
16424344 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRDMT1 Protein Structure

DNA_methylase

DNA_methylase: C-5 cytosine-specific DNA methylase (5 - 388)

  • 0
  • 100
  • 200
  • 300
  • 391 a.a.
Protein Preferred Names Protein Names

tRNA (cytosine(38)-C(5))-methyltransferase

  • DNA (cytosine-5)-methyltransferase-like protein 2

Recombinant TRDMT1 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P75711 DNMT2 Protein, Human (sf9, GST) O14717 (M1-E391) ≥ 90%, as determined by reducing SDS-PAGE.

TRDMT1 抗体

製品番号 製品名 アプリケーション 反応性
HY-P86854 Dnmt2 Antibody (YA6547) WB, ICC/IF, IHC-P, FC Human, Monkey

関連疾患

Diseases Alias
Dubowitz Syndrome

  • Dubowitz'S Syndrome

  • Dwarfism-Eczema-Peculiar Facies Syndrome

  • Intrauterine Growth Restriction, Short Stature, Microcephaly, Mild Intellectual Disability With Behavior Problems, Eczema, And Unusual And Distinctive Faci
Cartilage-Hair Hypoplasia

  • Metaphyseal Chondrodysplasia, Mckusick Type

  • CHH

  • Mckusick Type Metaphyseal Chondrodysplasia

  • Metaphyseal Dysplasia Without Hypotrichosis

  • Cartilage Hair Hypoplasia Like Syndrome

  • Metaphyseal Chondrodysplasia Mckusick Type

  • Chhv

  • Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only

  • Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency

  • Cartilage-Hair Syndrome

  • Mckusick'S Metaphyseal Chondrodysplasia Syndrome

  • Metaphyseal Chondrodysplasia, Recessive Type

  • Autosomal Recessive Metaphyseal Chondrodysplasia
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

  • Icf Syndrome

  • Immunodeficiency Syndrome, Variable

  • Ciid

  • Centromeric Instability, Immunodeficiency Syndrome

  • Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16

  • Icf
Chromophobe Renal Cell Carcinoma

  • Chromophobe Adenocarcinoma

  • Chromophobe Carcinoma Of Kidney

  • Kidney Chromophobe

  • Renal Cell Carcinoma, Chromophobe Cell

  • Crcc

  • Chrcc

  • Chromophobe Renal Cell Adenocarcinoma

  • Chromophobe Renal Carcinoma

  • Chromophobe Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS14999 TRDMT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19533 Trdmt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26029 Trdmt1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus TRDMT1 VGNC VGNC:36296
Rattus norvegicus TRDMT1 RGD RGD:1306292
Mus musculus TRDMT1 MGD MGI:1274787
Canis familiaris TRDMT1 VGNC VGNC:47790
Macaca mulatta TRDMT1 VGNC VGNC:106112
Others TRDMT1 NCBI