Mapk11 - mitogen-activated protein kinase 11 Gene

Also Known as P38b; Sapk2; p38-2; Prkm11; Sapk2b; p38beta; p38beta2

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 19094

About Mapk11

Chromosome 15: 89,026,689-89,033,831 reverse strand.GRCm39:CM001008.3

This gene has 4 transcripts (splice variants), 201 orthologues, 19 paralogues and is associated with 3 phenotypes. Broad expression in cortex adult (RPKM 22.5), CNS E14 (RPKM 2.2) and 2 other tissues.

Summary

Enables MAP kinase activity. Involved in MAPK cascade; bone development; and osteoblast differentiation. Acts upstream of or within negative regulation of cardiac muscle cell proliferation. Is active in cytosol. Is expressed in genitourinary system; lung; nervous system; and sensory organ. Orthologous to human MAPK11 (mitogen-activated protein kinase 11). [provided by Alliance of Genome Resources, Apr 2022]

Mapk11 Products (1)

mRNA Protein Name
NM_011161.5 NP_035291.4 mitogen-activated protein kinase 11

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables MAP kinase activity IMP
IMP: Inferred from mutant phenotype
20551513 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
enables protein serine/threonine kinase activity EXP
EXP: Inferred from Experiment
16364914 MGI
Biological Process GO Annotation Evidence 参考文献 由来
involved in MAPK cascade IMP
IMP: Inferred from mutant phenotype
20551513 MGI
involved in bone development IMP
IMP: Inferred from mutant phenotype
20551513 MGI
acts upstream of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
21768366 MGI
acts upstream of or within negative regulation of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
21768366 MGI
involved in osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
20551513 MGI
acts upstream of or within regulation of cardiac muscle cell proliferation IGI
IGI: Inferred from genetic interaction
21768366 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
is active in cytosol IMP
IMP: Inferred from mutant phenotype
20551513 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitogen-activated protein kinase 11

  • MAP kinase 11

  • MAP kinase p38 beta

  • MAPK 11

  • mitogen-activated protein kinase p38 beta

  • protein kinase, mitogen activated kinase, 11, p38beta

Mapk11 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
Mapk11 Q9WUI1 Mapk14 Mus musculus P47811
Y2H
15102471
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-186241 NuP-3 Inhibitor / Unkown
HY-RS08098 MAPK11 Human Pre-designed siRNA Set A / Unkown
HY-RS08099 Mapk11 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08100 Mapk11 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Mapk11 NCBI NCBI:5600