THSD7A - thrombospondin type 1 domain containing 7A Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 221981

About THSD7A

Cytogenetic location: 7p21.3 Genomic coordinates (GRCh38): 7:11,370,365-11,832,198 (from NCBI)

This gene has 4 transcripts (splice variants), 276 orthologues and 3 paralogues. Broad expression in kidney (RPKM 4.1), placenta (RPKM 2.1) and 17 other tissues.

Summary

The protein encoded by this gene is found almost exclusively in endothelial cells from placenta and umbilical cord. The encoded protein appears to interact with alpha(V)beta(3) Integrin and paxillin to inhibit endothelial cell migration and tube formation. This protein may be involved in cytoskeletal organization. Variations in this gene may be associated with low bone mineral density in osteoporosis. [provided by RefSeq, Aug 2010]

THSD7A Products (1)

mRNA Protein Name
NM_015204.3 NP_056019.1 thrombospondin type-1 domain-containing protein 7A precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in plasma membrane IDA
IDA: Inferred from direct assay
27214550 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THSD7A Protein Structure

TSP_1

TSP_1: Thrombospondin type 1 domain (198 - 246)

TSP_1

TSP_1: Thrombospondin type 1 domain (364 - 412)

TSP_1

TSP_1: Thrombospondin type 1 domain (638 - 694)

TSP_1

TSP_1: Thrombospondin type 1 domain (776 - 827)

TSP_1

TSP_1: Thrombospondin type 1 domain (1039 - 1075)

TSP_1

TSP_1: Thrombospondin type 1 domain (1101 - 1138)

TSP_1

TSP_1: Thrombospondin type 1 domain (1169 - 1219)

TSP_1

TSP_1: Thrombospondin type 1 domain (1290 - 1340)

TSP_1

TSP_1: Thrombospondin type 1 domain (1346 - 1388)

TSP_1

TSP_1: Thrombospondin type 1 domain (1419 - 1474)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1657 a.a.
Protein Preferred Names Protein Names

thrombospondin type-1 domain-containing protein 7A

  • thrombospondin, type I, domain containing 7A

THSD7A Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
THSD7A Q9UPZ6 LYVE1 Homo sapiens Q9Y5Y7
Y2H Prey Pooling
32296183
Intra
THSD7A Q9UPZ6 LYVE1 Homo sapiens Q9Y5Y7
Validated Y2H
32296183
Intra
THSD7A Q9UPZ6 LYVE1 Homo sapiens Q9Y5Y7
Y2H Array
32296183
Intra
THSD7A Q9UPZ6 VMA21 Homo sapiens Q3ZAQ7
Y2H Array
32296183
Intra
THSD7A Q9UPZ6 VMA21 Homo sapiens Q3ZAQ7
Y2H Prey Pooling
32296183
Intra
THSD7A Q9UPZ6 ELOVL5 Homo sapiens Q9NYP7
Y2H Array
32296183
Intra
THSD7A Q9UPZ6 ELOVL5 Homo sapiens Q9NYP7
Y2H Prey Pooling
32296183
Intra
THSD7A Q9UPZ6 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
THSD7A Q9UPZ6 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
THSD7A Q9UPZ6 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
THSD7A Q9UPZ6 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
THSD7A Q9UPZ6 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
THSD7A Q9UPZ6 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
THSD7A Q9UPZ6 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
THSD7A Q9UPZ6 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
THSD7A Q9UPZ6 LHFPL1 Homo sapiens Q86WI0
Y2H Array
32296183
Intra
THSD7A Q9UPZ6 LHFPL1 Homo sapiens Q86WI0
Y2H Prey Pooling
32296183
Intra
THSD7A Q9UPZ6 TMUB2 Homo sapiens Q71RG4
Y2H Array
32296183
Intra
THSD7A Q9UPZ6 TMUB2 Homo sapiens Q71RG4
Y2H Prey Pooling
32296183
Intra
THSD7A Q9UPZ6 COMT Homo sapiens P21964
Y2H Prey Pooling
32296183
Intra
THSD7A Q9UPZ6 COMT Homo sapiens P21964
Y2H Array
32296183
Intra
THSD7A Q9UPZ6 CD33 Homo sapiens P20138
Y2H Prey Pooling
32296183
Intra
THSD7A Q9UPZ6 CD33 Homo sapiens P20138
Y2H Array
32296183
Intra
THSD7A Q9UPZ6 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
Intra
THSD7A Q9UPZ6 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant THSD7A Proteins

製品番号 製品名 アクセッション番号 純度
HY-P78044 THSD7A Protein, Human (HEK293, His) Q9UPZ6 (A48-W1607) ≥ 95%, as determined by Bis-Tris PAGE.

関連疾患

Diseases Alias
Membranous Nephropathy

  • Membranous Glomerulonephritis

  • Glomerulonephritis, Membranous

  • Idiopathic Membranous Nephropathy

  • Idiopathic Membranous Glomerulonephritis

  • MBNP

  • Membranous Nephropathy, Susceptibility To

  • Extramembranous Glomerulonephritis

  • Mgn

  • Membranous Gn

  • Primary Membranous Glomerulonephritis

  • Primary Membranous Nephropathy

  • Nephropathy Membranous
Bronchiectasis 3
Kimura Disease

  • Kimura'S Disease

  • Eosinophilic Lymphogranuloma

  • Eosinophilic Granuloma Of Soft Tissue

  • Eosinophilic Hyperplastic Lymphogranuloma

  • Eosinophilic Lymphofollicular Granuloma

  • Eosinophilic Lymphofolliculosis
Osteoporosis

  • Postmenopausal Osteoporosis

  • Osteoporosis, Postmenopausal

  • Bone Mineral Density Quantitative Trait Locus

  • Bmnd

  • Osteoporosis, Involutional

  • Osteoporosis, Susceptibility To

  • Osteoporosis, Postmenopausal, Susceptibility

  • Bone Mineral Density Variation Qtl, Osteoporosis

  • OSTEOP

  • Involutional Osteoporosis

  • Senile Osteoporosis

  • Osteoporosis Postmenopausal

  • Bone Mineral Density, Quantitative Trait Locus

  • Osteoporosis, Senile

  • Idiopathic Osteoporosis

  • Bone Rarefaction Nos

  • Type 1 Osteoporosis
Histiocytoid Hemangioma

  • Angiolymphoid Hyperplasia With Eosinophilia

  • Epithelioid Haemangioma

  • Epithelioid Hemangioma
Goodpasture Syndrome

  • Anti-Glomerular Basement Membrane Disease

  • Anti-Gbm Disease

  • Pulmonary Renal Syndrome

  • Anti-Glomerular Basement Membrane Antibody Disease

  • Glomerulonephritis - Pulmonary Hemorrhage

  • Rapidly Progressive Glomerulonephritis With Pulmonary Hemorrhage

  • Anti-Gbm Syndrome

  • Goodpasture'S Syndrome

  • Anti-Basement Membrane Glomerulonephritis
Autoimmune Disease Of Urogenital Tract
Membranoproliferative Glomerulonephritis

  • Mesangiocapillary Glomerulonephritis

  • Dense Deposit Disease

  • Membranoproliferative Glomerulonephritis Type 2

  • Primary Membranoproliferative Glomerulonephritis

  • Mesangiocapillary Glomerulonephritis, Type Ii

  • Glomerulonephritis, Membranoproliferative

  • Chronic Glomerulonephritis, Lobular

  • Lobular Glomerulonephritis

  • Ddd

  • Glomerulonephritis Membranoproliferative Type 2

  • Mpgn 2

  • Membranoproliferative Glomerulonephritis Type Ii

  • Mesangiocapillary Glomerulonephritis Type 2

  • Mpgn

  • Primary Mpgn

  • Glomerulonephritis Membranoproliferative

  • Membranoproliferative Glomerulonephritis, Type Ii
Lipoid Nephrosis

  • Minimal Change Disease

  • Minimal Change Glomerulonephritis

  • Nephrotic Syndrome With Lesion Of Minimal Change Glomerulonephritis

  • Nephrotic Syndrome With Lesion Of Minimal Change Nephrotic Syndrome

  • Idiopathic Minimal Change Nephrotic Syndrome

  • Mcns

  • Minimal Change Glomerulopathy

  • Minimal Change Nephrotic Syndrome

  • Nephrotic Syndrome Minimal Change

  • Nephrosis, Lipoid

  • Glomerulonephritis, Minimal Change

  • Nephrotic Syndrome, Minimal Change
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS14505 THSD7A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19820 Thsd7a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26316 Thsd7a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus THSD7A RGD RGD:1566201
Bos taurus THSD7A VGNC VGNC:35850
Mus musculus THSD7A MGD MGI:2685683
Canis familiaris THSD7A VGNC VGNC:47358
Macaca mulatta THSD7A VGNC VGNC:79347
Felis catus THSD7A VGNC VGNC:66176
Others THSD7A NCBI